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Method for preparing oil soluble medicine slow releade micro ball

A slow-release microsphere and oil-soluble technology, which is applied in the direction of bulk transportation, can solve the problems of violent release, and achieve the effects of adjustable slow-release performance, excellent release stability, and simple preparation and operation

Inactive Publication Date: 2008-07-09
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But both of them have drug release peaks, and there is a phenomenon of violent release, so the inventor hopes to obtain a stable sustained-release preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The polymer used in the oil phase is polylactic acid-polyethylene glycol copolymer. The polymer adopts polylactic acid-polyethylene glycol with a molecular weight of polyethylene glycol of 4000, a copolymerization ratio of 4 / 1, and an intrinsic viscosity of 0.2175dl / g. Alcohol copolymer, the concentration is 10g / l, the drug concentration of fenofibrate is 0.6694g / l, the water phase is distilled water, the oil-water volume ratio is 1, under the state of stirring at 1000rpm, when the oil phase drops into the water phase, the obtained microspheres The diameter is 83.1±31nm, the drug encapsulation rate is 33.5%, and it can be released stably within 12 hours.

Embodiment 2

[0021] The copolymer concentration was 1 g / l, the fenofibrate drug concentration was 0.1014 g / l, and other conditions were the same as in Example 1, and the particle diameter of the obtained microspheres was 68±33 nm.

Embodiment 3

[0023] Without stirring, other conditions are the same as in Example 2, the particle size of the obtained microspheres is 4.005±1.847 μm, and the medicine cannot be well encapsulated.

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Abstract

The present invention discloses the preparation process of slowly releasing oil soluble medicine microballoon. The water solution of PVA, the water solution of PEG or distilled water as water phase; PLA-PEG copolymer as oil phase; and acetone solution of medicine are mixed via stirring to add oil phase into water phase and volatilized to eliminate acetone, and through further dialysis in dialyzing bag, un-enveloped medicine is eliminated. The present invention has microballoon size controllable below 150 nm and certain slow releasing property.

Description

technical field [0001] The invention relates to a preparation method of oil-soluble drug sustained-release microspheres, in particular to a preparation method of oil-soluble drug sustained-release microspheres soluble in acetone and insoluble in water. Background technique [0002] Polymer materials are increasingly used in the fields of biomedicine and pharmacy, among which biodegradable polymer materials are the most widely used. They have the function of being absorbed and metabolized by animals and humans, and have the following three advantages: ①The slow-release rate is mainly controlled by the degradation rate of the carrier, which is less dependent on the properties of the drug, and the selection range of parameters such as the amount of drug wrapping and geometric shape is wider. wide. ②The release rate is more stable. In diffusion-controlled release systems, the release rate generally decreases with time. If a degradable material is used as a carrier, as the mat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16
Inventor 任杰洪海燕
Owner TONGJI UNIV
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