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Biological active material for realizing percutaneous device biological sealing and method for making same

A technology of bioactive and biomedical materials, which is applied in the field of bioactive materials and its preparation for the realization of transdermal device biosealing, which can solve the problems of skin biosealing, inability to combine organically, and implant failure

Inactive Publication Date: 2008-06-04
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantage of metal materials is that they have excellent mechanical properties, but because biologically inert metal materials do not have biological activity, they cannot form an organic combination with tissues after implantation, that is, they cannot form a bioseal with the skin. After long-term implantation, they may also cause infection. Implantation failure

Method used

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  • Biological active material for realizing percutaneous device biological sealing and method for making same
  • Biological active material for realizing percutaneous device biological sealing and method for making same
  • Biological active material for realizing percutaneous device biological sealing and method for making same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Electrochemical surface modification biomedical material titanium metal of the present invention:

[0038] Using biomedical titanium metal material 1 as anode and cathode, in 1 mol / liter of H 2 SO 4 In the solution, after being treated for 60 seconds under the conditions of 155V DC voltage and ambient temperature of 28°C, and then washed with clean water such as deionized water, normal saline, or distilled water, an oxide containing hydroxyl group 3 was generated on the surface of titanium metal material 1. Titanium 2, a titanium metal material covered with titanium oxide or directly used as a percutaneous implant; Soaked at 37.4°C for 240 hours, a calcium-phosphorus coating is formed on the surface of the material. The calcium-phosphorus coating has good biocompatibility with the skin, so the surface-modified titanium material is used as a percutaneous implant for physical fitness and skin Forms a bioseal.

Embodiment 2

[0040] The coating surface modified biomedical material alumina ceramics of the present invention:

[0041] Biomedical alumina ceramics 10 are used as the base material, the surface roughness is Ra5 microns, calcium-phosphorus powder 11 is used as the raw material, nitrogen is used as the calcium-phosphorus plasma generation gas, and ionization is generated by heating under the condition of 400A strong current to generate plasma The surface of the calcium-phosphorus powder is melted under the action of the plasma, and the gas is sprayed onto the surface of the alumina ceramic substrate material at high speed to form a calcium-phosphorus coating. The alumina ceramic material covered with the calcium-phosphorus coating or directly Used as a percutaneous implant, the percutaneous implant absorbs calcium and phosphorus in the physiological environment at the implantation site, and produces a new calcium-phosphorus coating on the surface of the material, so that the material and the...

Embodiment 3

[0043] The chemical surface modification biomedical material titanium alloy of the present invention:

[0044] Biomedical titanium alloy 12 is used as the base material, soaked in 10 mol / L NaOH solution at a temperature of 60°C for 24 hours, and then heat-treated at 600°C for 24 hours, thereby producing titanium gel on the surface of the titanium alloy 13 , titanium alloy covered with titanium gel or directly used as a percutaneous implant, the percutaneous implant absorbs calcium and phosphorus in the physiological environment at the implantation site, and produces a calcium-phosphorus coating on the surface of the titanium alloy material, so that the material Form a bio-seal with the skin; or soak in a solution containing calcium and phosphorus in vitro, such as simulated body fluid, accelerated calcification solution, calcium and phosphorus solution containing protein, at 37.4°C for 240 hours, and generate calcium and phosphorus on the surface of the titanium alloy material....

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Abstract

The invention relates to a biological active material for realizing transderrnal device biological sealing, and its preparing process, wherein the biological medical material is modified on the surface, thus biologically active groups are formed to simulate adsorption calcium phosphoric ion, and calcium-phosphoric coating is also formed on the surface of the biological material, which reacts with human skin to result in tight adhesion.

Description

1. Technical field [0001] The invention relates to a biomedical material and its preparation technology, in particular to a bioactive material for realizing the biological sealing of a percutaneous device and a preparation method thereof. 2. Background technology [0002] A percutaneous device refers to an implant with one end implanted in the body and the other end exposed outside the body, which is used as a window for information exchange between the body and the outside. Information exchange includes stress transfer, material exchange, electrical signal input and output, etc. Since the transdermal device penetrates the skin, whether it can form a bio-seal with the skin is the key to its success, and the biocompatibility of the material used with the skin is a key factor determining whether the bio-seal can be formed. [0003] The materials that are used for transdermal devices at home and abroad have the reports of medical ceramics, medical macromolecules and medical me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00A61L31/00
Inventor 杨帮成吴尧虞奇峰包崇云陈继镛张兴栋
Owner SICHUAN UNIV
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