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Water soluble microcapsule for medicine and its production process

A production method and technology of microcapsules, which are applied in the field of pharmaceutical water-soluble microcapsules and production, can solve problems such as irregular shapes and poor water-solubility effects, and achieve the effects of uniform size, high utilization rate, and saving coating materials

Active Publication Date: 2008-04-23
DALIAN SANYI ANIMAL MEDICINE CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve technical problems such as poor water-solubility effect and irregular shape in the prior art, and provides a medicinal water-soluble microcapsule with good water-solubility effect and uniform shape and a production method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] a. Mix water-soluble starch and lactose powder in a ratio of 1:1 and place it on a fluidized bed. The loading capacity is 65-75% of the working capacity of the equipment. After the coating equipment is in normal operation, the adhesive is sprayed through cutting (side spraying) ) device, which is evenly sprayed onto the powder suspended in the hot air (fluidized state), and through continuous adjustment of technical parameters, the fluidized powder is continuously condensed into small particles, which gradually meet the requirements of the mother pellets. It is an aqueous solution of water-soluble starch and sodium carboxymethylcellulose, wherein the concentration of water-soluble starch is 20-30%, and the concentration of sodium carboxymethylcellulose is 1-3%;

[0018] b. Put the parent pellet particles into the coating bed, and wait for the coating equipment to operate normally, pass the antibiotics and other agents through the cutting and spraying device, and evenly c...

Embodiment 2

[0021] a. Mix water-soluble starch and lactose powder in a ratio of 1:1 and place it on a fluidized bed. The loading capacity is 65-75% of the working capacity of the equipment. After the coating equipment is in normal operation, the adhesive is sprayed through cutting (side spraying) ) device, evenly cutting and spraying on the powder suspended in hot air (fluidized state), through continuous adjustment of technical parameters, the fluidized powder is continuously agglomerated into small particles, gradually meeting the requirements of the mother pellets, bonding The agent is an aqueous solution of water-soluble starch and sodium carboxymethylcellulose, wherein the concentration of water-soluble starch is 20-30%, and the concentration of sodium carboxymethylcellulose is 1-3%;

[0022] b. Take a PBS solution with a concentration of sea bath sugar of 1-3%, a pH value of 6.8-7.2, and an ion concentration of 0.2mol / L as the active drug protection solution, and mix it with probioti...

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Abstract

The water soluble microcapsule for medicine is produced through spraying adhesive, which is water solution of water soluble starch in 20-30 wt% and sodium carboxymethyl cellulose in 1-3 wt%, onto the mixture of water soluble starch and lactose to prepare mother capsule; spraying medicine material onto the mother capsule to form medicine carrying layer; making alcohol solution of carboxymethyl cellulose in 5-8 % concentration and spraying the alcohol solution to the medicine carrying layer. The microcapsule can dissolve in stomach completely to make the medicine act fast in high utilization rate.

Description

Technical field: [0001] The invention relates to a pill and a production method, in particular to a medicinal water-soluble microcapsule with good water-dissolving effect and its production. Background technique: [0002] Known pharmaceutical microcapsules include a mother pill, a drug-loaded layer and a coating three-layer structure from the inside to the outside. The specific manufacturing method is to place ordinary starch in a fluidized bed, and after the coating equipment operates normally, spray a certain concentration of ordinary starch solution evenly on the ordinary starch (from top to bottom) to make mother pellets; Put a certain size of mother pellets into the coating bed, and when the coating equipment is running normally, spray chemical agents such as antibiotics on the mother pellets to reach the required thickness (drug amount) to make a drug-loaded layer; The pellets and the granules composed of the drug-loaded layer are loaded into the coating bed, and afte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50
Inventor 庄国宏
Owner DALIAN SANYI ANIMAL MEDICINE CO LTD
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