Catechol sodium complex and its prepn and application in medicine for preventing and treating cancer and tumor

A technology for sodium catechol and complexes, applied in the field of sodium catechol complexes and their preparation, achieving the effects of high yield, high purity, and easy availability of raw materials

Inactive Publication Date: 2007-11-21
CAPITAL NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, it has not been able to enter clinical application as an anti-cancer and anti-tumor drug. The reason is that its limited water solubility may be one of the influencing factors.

Method used

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  • Catechol sodium complex and its prepn and application in medicine for preventing and treating cancer and tumor
  • Catechol sodium complex and its prepn and application in medicine for preventing and treating cancer and tumor
  • Catechol sodium complex and its prepn and application in medicine for preventing and treating cancer and tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Weigh 0.6g of Na 3 PO 4 and 0.3g of catechol into 15ml of CH 3 OH, 15mlCH 3 CN and 8ml of ethylenediamine (H 2 NCH 2 CH 2 NH 2 ) in a mixed solvent, stirred on a magnetic stirrer for several hours, filtered, and diffused the mother liquor with ether. After one week, yellow crystals were precipitated.

[0020] Elemental analysis values ​​(%) are (theoretical values ​​in brackets): C, 55.66 (55.62); H, 6.31 (6.35); N, 9.30 (9.27);

[0021] NMR data:

[0022] 13 C NMR (solid state): C 1，6 , 150.6; C 7，12 ;154.3;C 2，5，8，11 ;114.7;C 3，4，9，10 ; 120.6.

[0023] 13 C NMR (D 2 O is a solvent): C 1.6，7，12 ;151.6;C 2，5，8，11 ;118.4;C 3，4，9，10 ; 121.2.

[0024] 1 H NMR (D 2 O is the solvent): H 2，5，8，11 ;6.65-6.67;H 3，4，9，10 ;6.76-6.78;H 13，14 ; 2.81.

[0025] Infrared spectral data (cm -1 ) is: N-H, 3411s; Ar-H: 3052m; C-O: 1277s, 1257s, 1235m; C-N: 1176s; M-O,; 855s, 869s.

[0026] X-ray crystal structure data: The chemical formula is:

[0027...

Embodiment 2

[0028] Embodiment 2 uses 1.0g Na 2 MoO 4 2H 2 O replaces Na in Example 1 3 PO 4 , other conditions are the same, the operation of Example 1 is repeated to obtain the same product as Example 1.

Embodiment 3

[0029] Example 3 with 1.2g Na 2 WO 4 2H 2 O replaces Na in Example 1 3 PO 4 , other conditions are the same, the operation of Example 1 is repeated to obtain the same product as Example 1.

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PUM

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Abstract

The catechol sodium complex has both catechol with latent anticancer and antitumor capacity and low toxicity sodium ion, and their cooperation makes the complex possess excellent water solubility and liposolubility and can enter effectively the disease focus part in life system to treat cancer and tumor. The catechol sodium complex may be used alone as anticancer and antitumor medicine or as the active component of anticancer and antitumor. The preparation process is to complex inorganic salt containing metal sodium ion and catechol ligand to form the catechol sodium complex inside water phase, organic phase or mixed phase in the presence of organic amine. The preparation process has easy-to-obtain material, low cost, separated crystal product, high product purity, high yield and high stability of the product under natural state.

Description

technical field [0001] The invention relates to a sodium catechol complex and a preparation method thereof. The compound can not only prevent the formation of cancer and tumors, but also inhibit the growth of cancer and tumors. It can be used to prepare medicines for preventing and treating cancer and tumor diseases. Background technique [0002] Catechol has anti-cancer and anti-tumor functions and has become a well-known fact in the fields of medicine, chemistry and biology. References include: [1] Kahl, R. In Oxidative Stress: Oxidants and Antioxidants; Ed.: Sie, H., Academic , London, 1991; 245; [2] Thompson, R.H. Naturally Occurring Quinones.III, Recent Advances, Chapman and Hall, London.1987; [3] Patai, S. The Chemistry of the Quinonoid Compounds, Parts 1 and 2, Wiley , New York.1974; [3]Patai, S. The Chemistry of the Quinonoid Compounds, Parts 1 and 2, Wiley, New York.1974. However, so far, it has not been able to enter clinical application as an anticancer and antin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F1/04A61K31/135A61P35/00
Inventor 鲁晓明
Owner CAPITAL NORMAL UNIVERSITY
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