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Application of germanium enriched golden needle fungus in preparation of medicine for treating lupus erythematosus

A lupus erythematosus and golden needle technology, applied in the field of medicine, can solve the problems of large side effects and unstable curative effect, achieve obvious effects, no toxic side effects, and improve the effect of reducing immune whole blood

Inactive Publication Date: 2007-09-19
ACAD OF STATE GRAIN ADMINISTRATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional treatment mainly relies on corticosteroid drug therapy, with large side effects and unstable curative effect

Method used

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  • Application of germanium enriched golden needle fungus in preparation of medicine for treating lupus erythematosus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1. germanium-rich Flammulina velutipes powder toxicology test report

[0008] 1. Materials

[0009] 1. Sample: germanium-rich Flammulina velutipes (Fr.) Sing., purchased from the Institute of Microbiology, Chinese Academy of Sciences. The preparation process is provided by the Chinese Invention Patent Application specification CN 1065783A)

[0010] 2. Experimental animals: healthy Kunming mice (approval number: Jingdongzi No. 9209M13) and Wistar rats (approval number: Jingdongzi No. 8707N08) bred in the breeding factory of the Institute of Zoology, Chinese Academy of Sciences were selected.

[0011] 2. Method

[0012] 1. Acute toxicity test: 20 healthy Kunming mice and 20 Wistar rats, 10 males and 10 males, were selected for the test respectively. Mice weighed 18-22 grams. Rats weighed 200-260 grams. Oral gavage with a dose of 10 g / kg body weight, dilute the sample with 2% starch paste to the required concentration, and mice are gavaged twice within 24 h...

Embodiment 2

[0036] Example 2. Preliminary study on anti-mutation effect of germanium-rich Flammulina velutipes powder

[0037] We conducted a preliminary study on the antimutagenic effect of "germanium-rich Flammulina velutipes powder" by using Chinese hamster lung (CHL) cell cycle blockade micronucleus assay.

[0038] 1. Materials

[0039] 1. CHL cells were provided by the Institute of Environmental Supervision, Chinese Academy of Preventive Medicine;

[0040] 2. Cytochalasin B (CytB), mitomycin C (MMC), MEM medium (Eagle), glutamine and other reagents were all purchased from Sigma Company, and calf serum was made in our laboratory according to known techniques;

[0041] 3. The "germanium-rich Flammulina velutipes powder" is provided by the National Grain Administration Research Institute, the same as in Example 1.

[0042] 2. Method:

[0043] CHL cells were routinely cultured with MEM supplemented with 10% calf serum, inoculated with 6×10 cells per plate, at 37°C, 5% CO 2 After 24 h...

Embodiment 3

[0053] Embodiment 3. The therapeutic effect of germanium-rich Flammulina velutipes powder on lupus erythematosus

[0054] 1. Case selection:

[0055]SLE (systemic lupus erythematosus) patients, a total of 20 cases. The diagnoses were all in line with the diagnostic criteria for SLE established by the American College of Rheumatology in 1982. There were 18 outpatients, 2 inpatients, 1 male and 19 females, aged 20-58 years. All cases had abnormal immune indicators, whole blood and / or thrombocytopenia.

[0056] 2. Observation method:

[0057] They were randomly divided into two groups with 10 cases in each group. The conditions were similar and there was no statistical difference. Both of them maintained the original treatment of traditional Chinese medicine and corticosteroids for SLE. During the observation period, the dosage of hormones was not increased, and conventional drugs for correcting anemia were not needed. The observation group was additionally given FG-25 powder ...

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Abstract

An application of the Ge-enriched Jinzheng mushroom powder in preparing the medicine for treating lupus erythematosus with high curative effect is disclosed.

Description

technical field [0001] The application of germanium-rich Flammulina velutipes powder in the preparation of medicines for treating lupus erythematosus belongs to the field of medicine. Background technique [0002] Germanium-rich Flammulina velutipes powder is a novel product with high biological activity prepared by using the bioactive substance recombination technology of Flammulina velutipes according to certain pharmaceutical properties of Flammulina velutipes, and through liquid culture of Flammulina velutipes. The strain used for production is Flammulina velutipes (Fr.) Sing. purchased from the Institute of Microbiology, Chinese Academy of Sciences. Germanium-rich Flammulina velutipes powder is rich in mushroom polysaccharides, rich in protein, bioactive factors and trace elements beneficial to the human body. This product has passed the animal acute toxicity test (rat and mouse) LD50>10g / kg body weight, according to acute toxicity classification, it is actually non...

Claims

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Application Information

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IPC IPC(8): A61K36/06A61P37/02
Inventor 程树峰伍松陵唐芳张晓琳
Owner ACAD OF STATE GRAIN ADMINISTRATION
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