A lab-on-a-
chip (LOC) device for
genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a
dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of
reagent reservoirs, a
lysis section downstream of the
dialysis section for lysing the target cells to release the genetic material therein, the
lysis section being in fluid communication with one of the
reagent reservoirs containing a
lysis reagent for lysing the target cells in the lysis section, a first
nucleic acid amplification section downstream of the lysis section for amplifying first
nucleic acid sequences in the genetic material, and, a second
nucleic acid amplification section downstream of the first nucleic acid amplification section for amplifying second nucleic acid sequences in the
amplicon from the first nucleic acid amplification section, wherein, the
dialysis section, the lysis section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate.