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Method for treatment of parkinson's disease

a parkinson's disease and treatment method technology, applied in the direction of capsule delivery, drug composition, nervous disorder, etc., can solve the problems of complicated long-term therapy, pulsatile dopaminergic stimulation,

Pending Publication Date: 2022-05-19
NEURODERM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, levodopa has a short half-life in plasma that, even under best common current standard of care, results in pulsatile dopaminergic stimulation.
Long-term therapy is therefore complicated by motor fluctuations and dyskinesia that can represent a source of significant disability for certain patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0187]A test was run in order to assess the plasma exposure of levodopa (LD) following the coadministration of LD and carbidopa (CD) in both subcutaneous (SC) and oral administrations. Accordingly, results obtained from a combined SC+oral administration were compared to results obtained from SC administration alone and from oral administration alone. An additive plasma exposure and PK profile was expected, i.e., it was expected that the SC+oral coadministration would provide results equal to the additive results of the SC and oral administrations, when each was administered separately.

Methods

[0188]16 healthy subjects (18-50 years) were treated in a crossover manner, i.e., sequentially, with a washout period of 6 days between the following two treatments:

[0189]Treatment A: A total dose of 180 / 22.5 mg LD / CD (formulation A) was administered by SC infusion over the course of 8 hours, at a steady infusion rate.

[0190]Treatment B: An immediate release (IR) tablet of 100 / 25 mg LD / CD was adm...

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Abstract

Disclosed is a method for the treatment of a neurological or movement disorder, e.g., Parkinson's disease, in an individual in need thereof, by parenteral administration of levodopa and a dopa decarboxylase inhibitor (DDCI), such as carbidopa, benserazide or any combination thereof, concomitantly with oral administration of levodopa, a DDCI, such as carbidopa, benserazide, or any combination thereof.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of the U.S. patent application Ser. No. 17 / 334,554, filed May 28, 2021, which claims the benefit of and priority to U.S. Provisional Patent Application No. 63 / 114,688, filed Nov. 17, 2020, the disclosure of which is incorporated by reference herein in its entirety.TECHNICAL FIELD[0002]The present invention provides a method for treatment of neurological or movement disorders such as Parkinson's disease by parenteral administration of levodopa or prodrug thereof and a dopa decarboxylase inhibitor (DDCI) or prodrug thereof, such as carbidopa, benserazide, or any combination thereof, concomitantly with oral administration of levodopa or prodrug thereof, a dopa decarboxylase inhibitor (DDCI) or prodrug thereof, such as carbidopa, benserazide, or any combination thereof.BACKGROUND[0003]Parkinson's disease is a degenerative condition characterized by reduced concentration of the neurotransmitter dopamine in th...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/198A61K9/00A61K9/48A61K47/18A61K9/20
CPCA61K31/198A61K9/0021A61K9/0053A61K9/2013A61K9/4808A61K47/183A61K9/4858A61K9/0019A61P25/00A61K47/18A61K47/02A61P25/16
Inventor BIRNBERG, TALADAR, LIATPERLSTEIN, ITAY
Owner NEURODERM
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