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Wound dressing comprising hyaluronic acid-calcium and polylysine and manufacturing method therefor

a technology of hyaluronic acid and polylysine, which is applied in the field of wound dressings comprising hyaluronic acidcalcium and polylysine, can solve the problems of affecting the healing effect of patients, and requiring surgical and medical hemostatic means, so as to minimize the reaction caused by foreign substances and facilitate the preparation. , the effect of superior hemostatic function

Pending Publication Date: 2021-07-29
YOUREH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a liquid, foam, and film-type wound dressing that can be applied to both internal and external wound areas in the body. The dressing is made from a mixed solution of hyaluronic acid-calcium and polylysine adjusted to pH 8.4 or higher. The dressing meets requirements for deep body cavity wound healing, is biodegradable, and has no residual toxicity or interference with the wound healing process. It also has superior hemostatic action and prevents tissue adhesion and wound infection. The film-type dressing can protect and treat wound areas for a certain period of time under a wet condition.

Problems solved by technology

Damage to blood vessels due to surgical procedures and physical injury causes bleeding.
However, severe bleeding may require surgical and medical hemostatic means.
Since Tachocomb® Topical Thrombin contains fibrinogen, thrombin, collagen and the like which are extracted from blood of cows or humans, it may cause a risk of infection and a hypersensitivity reaction during treatment.
In addition, Surgicel®, Avitene® and ChitoClot® are disadvantageous in that blood coagulation performance and adhesiveness to an injured area are insufficient, and that the regeneration at the bleeding area is insignificant due to its low biocompatibility.
Conventional film-type anti-adhesives have an excellent adhesion inhibitory effect, but they have a limitation in that it is difficult to apply for a microscopic surgery using a laparoscope, the applicability of which has recently been expanded.
Meanwhile, solution-type anti-adhesives are disadvantageous in that they are not easily adhered to the wounds due to exudates such as blood or the like which is appeared after surgery, and they may be removed together with the exudates or rapidly absorbed in the peritoneum.
As a result, their role as a barrier for preventing adhesion does not last sufficiently.
In addition, cow-derived collagen has been reported as having safety issues due to the bovine spongiform encephalopathy (BSE) factor.
Collagen extracted from other animals also carries the risk of animal virus infection.
Hyaluronic acid has limitations in that when used alone, it decomposes relatively fast in the body, and diffuses and flows down the surface of a wound in a short time.
However, a complicated process for removing the crosslinking agent is required, and the use of an additive such as carboxymethyl cellulose or the like may raise a safety issue due to its biodegradability.

Method used

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  • Wound dressing comprising hyaluronic acid-calcium and polylysine and manufacturing method therefor
  • Wound dressing comprising hyaluronic acid-calcium and polylysine and manufacturing method therefor
  • Wound dressing comprising hyaluronic acid-calcium and polylysine and manufacturing method therefor

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examples

[0064]Hereinafter, the present invention will be described in more detail by way of examples. However, the examples presented herein are given for illustrative purposes only, and it is not intended the scope of the invention to be limited to or by the examples.

example 7

Preparation of Liquid-Type Wound Dressing

[0066]Sodium chloride was added to the mixed solution having a composition of Example 2 such that its concentration was 0.8% and resulting solution was filled into a prefilled syringe to prepare a liquid-type wound dressing.

example 8

Preparation of Film-Type Wound Dressing

[0067]The mixed solution having a composition of Example 2 was poured into a 10 cm×10 cm mold, and allowed to stand in a 40° C. incubator for 12 to 16 hours to prepare a film-type wound dressing.

[0068]FIG. 1 is a photographic image showing the appearances of the pads prepared from the compositions of Examples 1 to 6, and Comparative Examples 1 and 2. As shown in Table 1 and FIG. 1, the pads were formed well for the compositions of Examples 1 to 6. However, the higher the HA content, the harder the pad, and the pads tended to become harder even when the PLL content was increased. Meanwhile, when the PLL content exceeded 0.75% (w / v) or when the HA content exceeded 1% (w / v) in the solution, the degree of hardness was too high and the pad became brittle. Therefore, it was evaluated to be appropriate that the HA content did not exceed 1.0% and the PLL content did not exceed 0.75% when providing the wound dressing in a foam or film-type.

[0069]In orde...

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Abstract

The present invention relates to a wound dressing comprising hyaluronic acid-calcium and polylysine, and a manufacturing method therefor, the method comprising: (1) a step for adjusting each of the pH values of a hyaluronic acid-calcium salt and a polylysine aqueous solution to 8.4 or higher, and then mixing the hyaluronic acid-calcium salt and the polylysine aqueous solution to obtain a mixture liquid; and (2) obtaining a wound dressing from the mixture liquid obtained in Step (1).

Description

TECHNICAL FIELD[0001]The present invention relates to a wound dressing comprising hyaluronic acid-calcium and polylysine, and a preparation method thereof.BACKGROUND ART[0002]Damage to blood vessels due to surgical procedures and physical injury causes bleeding. Mild surface bleeding eventually stops by the action of physiological hemostasis, a complex cascade between blood vessels, platelets and plasma factors. However, severe bleeding may require surgical and medical hemostatic means. In the surgical hemostasis, suturing of a ruptured blood vessel or an application of a hemostatic sponge or the like to an injured area can assist the surgical hemostasis. Hemostatic sponges or compositions are useful in surgery, vascular surgery, dental surgery and the like.[0003]Previously-developed hemostatic products include sponge-type Tachocomb® Topical Thrombin which contains in vivo hemostatic coagulation factors and thereby can promote blood coagulation, and Surgicel®, Avitene®, ChitoClot® a...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61K31/785A61L15/22A61K31/728A61L15/44A61L15/42A61L15/64
CPCA61L26/0052B29C35/16A61L15/225A61K31/728A61L15/44A61L15/425A61L26/0066A61L26/009A61L15/64A61L2300/236A61L2300/252A61L2400/04A61L2300/404A61L2300/418A61L2300/424A61K31/785A61L15/46A61L26/0085A61L2300/10C08L5/08C08L77/04A61L15/28A61L15/32B29K2105/04B29L2031/753
Inventor UM, HYANG MAESEOL, JA YOUNG
Owner YOUREH CO LTD
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