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Transdermal delivery of doxylamine succinate and pyridoxine hydrochloride

a technology which is applied in the direction of digestive system, organic active ingredients, pharmaceutical non-active ingredients, etc., can solve the problems of delayed absorption of doxylamine succinate and pyridoxine hydrochloride, inconvenient multi-dose regimen, etc., to treat and/or prevent nausea or nausea, effect of preventing nausea or nausea

Inactive Publication Date: 2018-09-06
AEQUUS PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides pharmaceutical compositions for transdermal delivery of Doxylamine and Pyridoxine. These compositions can be in liquid form and contain a vehicle system, which can be a solvent, enhancer, and pH adjusting agent. The vehicle system can include glycols, polyhydric alcohols, alcohols, sulfoxides, pyrrolidones, mineral oil, vegetable oil, acids, glycols, esters, fatty acids, amides, urea, polyoxyethylene fatty alcohols, phospholipids, or nanocarriers. The liquid formulation can also contain other active metabolites of Doxylamine and Pyridoxine. The invention also provides an exemplary liquid formulation for transdermal delivery of Doxylamine and Pyridoxine. The technical effect of the invention is to provide a more effective and efficient way to deliver these drugs through the skin for therapeutic purposes.

Problems solved by technology

This multiple dose regimen is inconvenient for pregnant women, particularly for those who experience vomiting within a short time after dosing (i.e., within one hour) and have uncertainty as to whether taking another dose would be permissible.
The second challenge is taking the dose on an empty stomach because the absorption of Doxylamine Succinate and Pyridoxine Hydrochloride gets delayed when administered with food.

Method used

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  • Transdermal delivery of doxylamine succinate and pyridoxine hydrochloride
  • Transdermal delivery of doxylamine succinate and pyridoxine hydrochloride
  • Transdermal delivery of doxylamine succinate and pyridoxine hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

example 1

Liquid Formulations

[0162]

Formulation 016Formulation 080Ingredients(% w / w)(% w / w)Doxylamine Succinate8.95% 9%Pyridoxine Hydrochloride8.25% 8.25%  Dimethylsulfoxide31%30.25%   Propylene Glycol—3%Dipropylene Glycol5.8% 3%Polyethylene Glycol 400—3%Hexylene Glycol—4.5% Ethanol 6%—Propylene glycol 4%4%monolauratetype (II)Diethylene Glycol18%17.25%   Monoethyl EtherWater18%17.75%   pH4.7-5.14.7-5.1Formulation 014Formulation 015Ingredients(% w / w)(% w / w)Doxylamine Succinate—9.8%Pyridoxine Hydrochloride 9%—Dimethylsulfoxide34% 34%Dipropylene Glycol6.5% 6.5%Ethanol6.5% 6.5%Propylene glycol 4% 4%monolauratetype (II)Diethylene Glycol20% 20%Monoethyl EtherWater qs to100% 100% pH adj NaOH or HCl5.035.10

[0163]In another embodiment, the invention provides pharmaceutical compositions as semisolid formulations for transdermal delivery of Doxylamine and / or Pyridoxine. In one aspect the invention further provides semisolid formulation comprising Doxylamine, Pyridoxine and a Vehicle system. In another as...

example 2

Semisolid Formulations

[0169]

Formulation 046Formulation 054Ingredient(% w / w)(% w / w)Doxylamine Succinate   9%   9%Pyridoxine Hydrochloride 8.25% 8.25%Dimethylsulfoxide30.25%32.25%Propylene glycol   4%   4%monolauratetype (II)Diethylene Glycol17.25%17.25%Monoethyl EtherHexylene Glycol  10%  10%Glycerine—   3%Water17.75%12.75%Hydroxypropyl 3.50% 3.50%cellulose HFpH4.8-5.14.8-5.1Formulation 063Formulation 064Ingredient(% w / w)(% w / w)Doxylamine Succinate   9%—Pyridoxine Hydrochloride—8.25%Dimethylsulfoxide30.25%30.25% Propylene glycol   4%  4%monolaurate type (II)Diethylene Glycol17.25%17.25% Monoethyl EtherHexylene Glycol18.25% 19%Hydroxypropyl 3.50%3.50%cellulose HFWater qs 100% 100%pH adj with NaOH / HCl5.005.00

[0170]In yet another embodiment, the invention provides pharmaceutical compositions as a polymer matrix for transdermal delivery of Doxylamine and / or Pyridoxine. In one aspect the invention further provides a polymer matrix comprised of Doxylamine, Pyridoxine and a Vehicle system. ...

example 3

Polymer Matrix

[0175]

Formulation M001Ingredient(% w / w)Doxylamine Succinate8.5% Pyridoxine Hydrochloride8.5% Dimethylsulfoxide13.5% Diethylene glycol10.5% monoethyl etherPropylene Glycol 4%Monolaurate (type II)Glycerine26%Bentonite15%Hydroxypropyl methylcellulose14%(Methocel E4M Premium CR)

[0176]Optimum mixture experiments were used to select the level of the variables in pharmaceutical compositions comprising liquid formulations, semisolid formulations and polymer matrix.

[0177]The effect of different amount of Doxylamine Succinate and Pyridoxine Hydrochloride on the in vitro flux or release profile of doxylamine succinate and pyridoxine hydrochloride were evaluated using human cadaver skin.

[0178]The concentration or amount of drug in the pharmaceutical composition influences the drug delivery or flux. The invention further provides, different amount of Doxylamine Succinate and Pyridoxine Hydrochloride in pharmaceutical compositions. The amount of Doxylamine Succinate and Pyridoxine H...

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Abstract

Pharmaceutical compositions for simultaneous transdermal delivery of Doxylamine and Pyridoxine comprising Doxylamine or its salts, Pyridoxine or its salts or its active metabolites and a vehicle system wherein pharmaceutical compositions are liquid formulations, semisolid formulations and polymer matrices. Further pharmaceutical compositions can be incorporated into transdermal delivery systems or transdermal patches. The invention provides a method for treatment of nausea and vomiting in general, and for pregnant women in particular by continuous and simultaneous transdermal delivery of Doxylamine and Pyridoxine. This is to be accomplished through topical application of pharmaceutical compositions or by application of a transdermal delivery system or transdermal patch to the surface of the skin wherein the duration of application is once in a day, once every two days, once every three days, once every four days, once every five days, once every six days, or once in a week.

Description

[0001]This application is a divisional application of U.S. Ser. No. 15 / 228,382 filed Aug. 4, 2016, which claims benefit under 35 U.S.C. § 119(e) of U.S. Provisional Patent Application No. 62 / 205,941, filed Aug. 17, 2015, the contents of which are incorporated in their entirety herein.BACKGROUND OF THE INVENTION1. Field of Invention[0002]The present invention relates to the field of simultaneous transdermal delivery of Doxylamine or its various salts and Pyridoxine or its various salts and active metabolites from Novel pharmaceutical compositions. The pharmaceutical compositions have simultaneous in vitro release profile of Doxylamine and Pyridoxine from 1-3 days and 1-7 days. In particular, the pharmaceutical compositions of the present invention includes liquid formulations, semisolid formulations, and polymer matrix formulations comprised of Doxylamine, Pyridoxine and a vehicle system. Surprisingly, from a liquid formulation the average in vitro flux for Doxylamine Succinate and P...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/4415A61K9/06A61K31/4402A61K9/00A61K47/10A61K47/24A61K47/38
CPCA61K47/38A61K47/24A61K47/10A61K9/0014A61K31/4415A61K9/06A61K31/4402A61P1/08A61K2300/00
Inventor PLAKOGIANNIS, FOTIOS M.MCAFEE, DONALDLATHER, TAMANNABOROVINSKAYA, MARINA
Owner AEQUUS PHARMA INC
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