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Composition preventing necrotic enteritis in galloanserans

a technology of composition and enteritis, applied in the field of composition preventing necrotic enteritis in galloanserans, can solve the problems of sudden increase in mortality, short clinical illness, and necrotic enteritis

Inactive Publication Date: 2016-09-08
PERSTORP AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about using a glycerol ester composition to prevent and treat necrotic enteritis in galloanserans, such as chickens and turkeys. The composition contains a specific blend of short chain fatty acids, including glyceryl tributyrate, glyceryl dibutyrate, and glyceryl monobutyrate. The composition helps to balance or normalize the gut flora, preventing the growth of harmful bacteria and reducing the risk of necrotic enteritis. The use of the glycerol ester composition is more efficient than giving the animal butyric acid in the form of glyceryl monobutyrate.

Problems solved by technology

Necrotic enteritis has become an emerging problem especially among poultry and is characterized by severe necroses of intestinal mucosa.
The clinical illness is usually very short and often the only signs are a sudden increase in mortality.
Toxins produced by the bacteria cause damage to the small intestine, but also liver lesions, and mortality.
However, in certain conditions, some species are thought to be capable of causing diseases or malfunction by producing infection or increasing cancer risk for the host.

Method used

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  • Composition preventing necrotic enteritis in galloanserans

Examples

Experimental program
Comparison scheme
Effect test

embodiment example

[0021]In vivo trial on the efficacy of glyceryl butyrates to control Clostridium perfringens-induced necrotic enteritis in broiler chicken.

Bacterial Strains and Vaccines

[0022]The challenge strain used in the in vivo trials, C. perfringens strain 56, was isolated from the gut of a broiler chicken with necrotic lesions from a flock with weight gain problems and has been shown to be highly virulent in earlier in vivo trials. The strain was classified as a type A strain (netB positive, beta-2 and enterotoxin negative) and produces moderate amounts of alpha toxin in vitro (Gholamiandehkordi et al., 2006).

[0023]For inoculation, the strain was grown for 24 h in Brain Heart Infusion broth (BHI, Oxoid, Basingstoke, England).

[0024]A ten-fold dose of the anticoccidial vaccine Paracox®-8 (Schering-Plough Animal Health, Brussels, Belgium), containing live, attenuated oocysts of Eimeria (E.) acervulina (two lines), E. brunetti, E. maxima, E. necatrix, E. praecox, E. mitis and E. tenella was used ...

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Abstract

The present invention refers to the use of a glycerol ester composition of at least one short chain fatty acid for preventing and / or alleviating necrotic enteritis in the gastric tract of galloanserans. The glycerol ester composition comprises at least 75% by weight of glyceryl tributyrate, below 25% by weight of glyceryl dibutyrate and below 8% by weight of glyceryl monobutyrate. The present invention also refers to the use of said composition for modulating the gut flora of galloanserans.

Description

FIELD OF THE INVENTION[0001]The present invention refers to the use of a glycerol ester composition of at least one short chain fatty acid for preventing and / or alleviating necrotic enteritis in the gastric tract of galloanserans. The glycerol ester composition comprises at least 75% by weight of glyceryl tributyrate, below 25% by weight of glyceryl dibutyrate and below 8% by weight of glyceryl monobutyrate. The present invention also refers to the use of said composition for modulating the gut flora of galloanserans.BACKGROUND OF THE INVENTION[0002]Necrotic enteritis is an acute infection affecting galloanserans. Galloanserans are divided into the subgroups galliformes (landfowls) like chicken, turkey, grouse and pheasant, and anseriforms (waterfowls) like ducks, goose and swan. Necrotic enteritis has become an emerging problem especially among poultry and is characterized by severe necroses of intestinal mucosa. The clinical illness is usually very short and often the only signs a...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/225A23K50/70A23K50/75A23K20/158A61K9/50A61K9/00
CPCA61K31/225A61K9/50A23K50/70A23K50/75A23K20/158A61K9/0056A61K31/22A61P1/04A61K9/167A23V2002/00A61K2300/00A23V2200/32A23V2250/1884
Inventor VAN IMMERSEEL, FILIPSYGALL, RICHARDVAN DRIESSCHE, KAROLIENDUCATELLE, RICHARDSCHWARZER, CONRAD GERARD
Owner PERSTORP AB
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