Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof
a technology of osmotic pump and controlled release, which is applied in the direction of biocide, colloidal chemistry, drug compositions, etc., to achieve the effects of constant plasma concentration of active substances, rapid onset of drugs, and increased drug release ra
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example 1
[0098]The method of preparing the paliperidone double-layered osmotic pump controlled release tablet is as follows:
[0099]The preparation of the drug layer: the drug layer composition except for stearic acid were weighted according to the formulation of Table 1 and then added into a fluidized bed after mixed uniformly, 95% ethanol was sprayed onto granules till the particle size is appropriate. After fully dried, the granules were passed through a 20-mesh sieve, and then stearic acid was added therein, and mixed to be ready for use.
[0100]The preparation of the push layer: the push layer composition except for stearic acid were weighted according to the formulation of Table 1 and then added into a fluidized bed after mixed uniformly, 95% ethanol was sprayed onto the granules till the particle size is appropriate. After fully dried, the granules were passed through a 20-mesh sieve, and then stearic acid was added therein, and mixed to be ready for use.
[0101]Press of the double-layered ...
example 2
[0106]Paliperidone double-layered osmotic pump controlled release tablet was prepared according to the formulation of Table 1 in the manner described in Example 1, except that 139 mg granules of the drug layer composition were used during the pressing of the double-layered tablet core.
example 3
[0107]Paliperidone double-layered osmotic pump controlled release tablet was prepared according to the formulation of Table 1 in the manner described in Example 1, except that 138 mg granules of the drug layer composition were used during the pressing of the double-layered tablet core.
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