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Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof

a technology of osmotic pump and controlled release, which is applied in the direction of biocide, colloidal chemistry, drug compositions, etc., to achieve the effects of constant plasma concentration of active substances, rapid onset of drugs, and increased drug release ra

Active Publication Date: 2012-11-29
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0070]The beneficial effects of the present dosage form are based on the advantages of the osmotic pump controlled release dosage form, specifically embodied as followings.
[0071](1) The dosage form according to the present invention has a unique release behavior, that is, it shows an increasing drug release rate at early release stage, and a constant release rate at the later release stage. The designed drug release behavior can ensure the quick release of the drug at early stage so as to achieve a rapid onset of the drug, and at the same time, the later steady release rate can avoid the adverse reaction (extrapyramidal symptoms) resulted from the fluctuation of plasma concentration. The results of the in vivo pharmacokinetic investigation show that the paliperidone double layered osmotic pump controlled release tablet according to the present invention can quickly onset, and maintain a relatively constant plasma concentration of the active substance and a sustained therapeutic effectiveness of the active substances, and therefore, the fluctuation in plasma concentration is smaller and compliance is better.
[0072](2) The impact of the factors such as the pH of the media, gastric peristalsis and food is small, and the in vitro and in vivo relevance is good.
[0073](3) The phenomena of large fluctuation range in the plasma drug concentration caused by common oral dosage form is avoided.
[0074](4) The frequency of administration is reduced, and the safety, efficacy and compliance of the administration are greatly improved.
[0075](5) The present invention uses a double-layered osmotic pump controlled release system. Compared with the commercially available capsule-shaped controlled release tablets, the present invention greatly simplifies the production process, and adopts the common production equipments without any special equipment, and thus decreases production cost greatly and is suitable for industrial production.

Problems solved by technology

Medication therapy is one of the most commonly-used and effective treatment methods so far, and it can not only effectively control the schizophrenic symptoms, but also significantly control and reduce the frequency and intensity of the onset of the disease.
(1) It needs a special preparation process with a high production cost. The preparation process of the three-layered osmotic pump controlled release tablet is comparatively complicated, wherein it requires to prepare two kinds of drug layer particles with different drug contents and determined respectively the drug content, and then press into tablet, and thus the preparing period is long with more workload. The common used doses of paliperidone include 3 mg, 6 mg, and 9 mg, which belong to the low dose drug, and thus paliperidone has high requirements for content uniformity of the tablet core. But for a three-layered tablet, it is more difficult to achieve a satisfactory content uniformity Therefore, the preparation of a three-layer capsule shaped osmotic pump controlled release tablet requires a specific tablet compressor (three-layered tablet press), with a higher machining precision.
(2) The main excipient for tablet core has a poor thermal stability. Polyoxyethylene is a kind of high molecular polymer with poor thermal stability and which has low glass transition temperature (62˜67° C.). Due to the above features, it has the following problems during the industrial production and storage. (i) It is difficult to dry off the solvent during granulation process. The drying temperature for polyoxyethylene is generally less than 40° C., thus easily leading to problems of insufficient dryness and high residue of organic solvent; and if a complete dryness is required, it requires a relatively long drying duration, which results in higher production cost. (ii) The storage temperature of the tablet should not be too high, and the tablet has to be stored in a cool, dark place, which increases the storage cost. Meanwhile, a high storage temperature tends to cause some changes in the physicochemical properties of polyoxyethylene, such as, the oxidative degradation of polyoxyethylene, the decrease in the viscosity of the tablet core, which eventually result in the acceleration of the release of the controlled release tablet, and this will increase potentially dangerous factors to the treatment of patients. (iii) During high-speed tablet pressing, the punch die repeatedly rubs to generate heat, and when the temperature reaches about 50° C., phenomena such as sticking, rough appearance of tablet core, rolled edge in part of the tablet core would likely appear. Therefore, it usually requires a special cooling equipment to control the temperature of punch die. For the osmotic pump controlled release tablet, the rolled edge in part of the tablet core is likely to cause vulnerable point in the coating membrane in the said part, which may lead to the fracture of the coating membrane in the course of release. Consequently, it affects the release rate of the drug, and more seriously, a sudden release of the drug caused by the fracture of the coating membrane may directly contribute to the fluctuation of blood concentration, thus increase the potential risk and adverse reaction of the administration of the psychotic patients, which goes against the purpose for preparing osmotic pump controlled release tablet.
(3) The three-layered capsule shaped osmotic pump controlled release system releases paliperidone at a substantially ascending release rate, which results in a relatively large fluctuation range of blood concentration, and thus reduces the safety, effectiveness and compliance of the administration.

Method used

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  • Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof
  • Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof
  • Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof

Examples

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Effect test

example 1

[0098]The method of preparing the paliperidone double-layered osmotic pump controlled release tablet is as follows:

[0099]The preparation of the drug layer: the drug layer composition except for stearic acid were weighted according to the formulation of Table 1 and then added into a fluidized bed after mixed uniformly, 95% ethanol was sprayed onto granules till the particle size is appropriate. After fully dried, the granules were passed through a 20-mesh sieve, and then stearic acid was added therein, and mixed to be ready for use.

[0100]The preparation of the push layer: the push layer composition except for stearic acid were weighted according to the formulation of Table 1 and then added into a fluidized bed after mixed uniformly, 95% ethanol was sprayed onto the granules till the particle size is appropriate. After fully dried, the granules were passed through a 20-mesh sieve, and then stearic acid was added therein, and mixed to be ready for use.

[0101]Press of the double-layered ...

example 2

[0106]Paliperidone double-layered osmotic pump controlled release tablet was prepared according to the formulation of Table 1 in the manner described in Example 1, except that 139 mg granules of the drug layer composition were used during the pressing of the double-layered tablet core.

example 3

[0107]Paliperidone double-layered osmotic pump controlled release tablet was prepared according to the formulation of Table 1 in the manner described in Example 1, except that 138 mg granules of the drug layer composition were used during the pressing of the double-layered tablet core.

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Abstract

A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and / or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a controlled release dosage form of a benzoisoxazole derivative, and more particularly, to a paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof. The paliperidone double-layered osmotic pump controlled release tablet may be used for the treatment of schizophrenia and bipolar mania.BACKGROUND OF THE INVENTION[0002]Schizophrenia, which is characterized by the change of basic personality, the schism of thinking, feeling and behavior, and the disharmony of psychomotility and surroundings, is a most common type of mental illness and belongs to the severe type. Schizophrenia mainly occurs in young and middle-aged people without organic change, and it is a functional psychosis. Patients suffering from schizophrenia generally have no impediment in consciousness and intelligence, but when there is schizophrenic attack, it not only affects the labor capacity of the patients, but also exe...

Claims

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Application Information

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IPC IPC(8): A61K9/24B05D5/00A61P25/18A61K9/28A61K31/519
CPCA61K31/517A61K9/2086A61K9/2866A61K9/0004A61P25/18A61P25/24A61K9/209A61K31/519
Inventor GAN, YONGZHU, CHUNLIUYANG, QINGMINWANG, JINGYIZHENG, XIAOQINGGAN, LIZHANG, XINXIN
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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