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Androgen modulators

a technology of androgen receptors and modulators, which is applied in the field of androgen receptor modulators, can solve the problems of balding, common problem that medical science has yet to alleviate, and gradual changes in the width and length of the hair shaft, so as to enhance the lean meat to fat ratio in the animal, improve the effect of feeding efficiency and increase the growth ra

Inactive Publication Date: 2010-02-25
PFIZER INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0040]In a further embodiment the compounds can be used in livestock such as cattle, pigs, chickens, fish, etc. The compounds will increase the growth rate, and enhance the lean meat to fat ratio in the animals, and improve feed efficiency.

Problems solved by technology

Alopecia, or balding, is a common problem which medical science has yet to alleviate.
Gradual changes in the width and length of the hair shaft are experienced over time and with increasing age, prematurely in some.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

4-(5-Hydroxy-5-methyl-bicyclo[2.2.1]hept-2-yloxy)-2-trifluoromethyl-benzonitrile

[0197]

[0198]NaH (0.10 g, 1.75 mmol, 60% in mineral oil) was suspended in 15 ml of dry THF (tetrahydrofuran) at 0° C. under nitrogen (N2) gas, then 4-fluoro-2-(trifluoromethyl)-benzonitrile (0.3 g, 1.59 mmol) was added, this mixture was stirred at 0° C. under N2 for 10 minutes, before adding 2-methyl-bicyclo[2.2.1]heptane-2,5-diol (0.23 g, 1.59 mmol). The reaction mixture was stirred at 0° C. for 2 hours (h), then room temperature (RT) for 1 h. It was quenched with 50 ml of distilled water, extracted with ethyl acetate (3×30 ml), the organic layer was washed with saturated NaHCO3 (three times), the solvent was removed to yield the crude product, it was purified by column with hexane:ethyl acetate=1:1 as the elute.

[0199](MS: 312.1 (M+1 for C16H16NF3O2) LCMS: C-18 Column (25% H2O / 75% CH3CN), Ret. Time: 1.31 min Purity: 100%)

example 2

4-(trans-2-Methyl-cyclopentyloxy)-2-trifluoromethyl-benzonitrile

[0200]

[0201]Trans-2-Methylcylopentanol (50 mg, 0.5 mmol) was added to a flame dried round bottom flask under nitrogen containing 0.5 mL of dry tetrahydrofuran (“THF”) and cooled to 0° C. A 1.0 M solution of potassium t-butoxide in t-butanol (0.5 mL) was added dropwise and the reaction mixture stirred at 0° C. for 0.5 h. The above solution was then transferred via syringe to a flask containing 2-Trifluoromethyl-4-fluoro-benzonitrile (95 mg, 0.5 mmol) in 0.5 mL of THF at 0° C. The mixture was stirred at 0° C. for 3 h, warmed to room temperature and stirred for 16 h. The reaction mixture was then cooled to 0° C., poured into a seperatory funnel containing 8 mL of water, and extracted with 10 mL of methyl tert-butyl ether. The organic phase was washed with water, brine, dried (MgSO4), concentrated in vacuo, and the residue purified by reverse phase HPLC (Shimadzu) to give 112 mg 4-(trans-2-Methyl-cyclopentyloxy)-2-trifluoro...

example 3

4-(2-(R)-Phenyl-1-(S)-cyclohexyloxy)-2-trifluoromethyl-benzonitrile

[0202]

[0203]The title compound was prepared according to the procedure described in Example 2, except that 1-(S)-2-(R)-Phenyl-cyclohexyanol was used as the starting alcohol to give 66 mg of the desired product. GC / MS: 345 (M / Z for C20H18F3NO).

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Abstract

The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

Description

CROSS REFERENCE[0001]This application is a divisional of U.S. patent application Ser. No. 11 / 175,097, filed on Jul. 5, 2005, now allowed, which claims the benefit of U.S. Provisional Application No. 60 / 586,160 filed Jul. 8, 2004 and U.S. Provisional Application No. 60 / 598,033, filed Aug. 2, 2004.FIELD OF THE INVENTION[0002]The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease sebum secretion and to stimulate hair growth.BACKGROUND OF THE INVENTION[0003]Alopecia, or balding, is a common problem which medical science has yet to alleviate. While androgens are associated with balding, the physiological mechanism by which this hair loss occurs is not known. However, it is known that hair growth is altered in individuals afflicted with alopecia.[0004]Hair does not grow continuously but undergoes cycles of activity involving perio...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/655C07C255/00
CPCC07C255/54C07C2101/04C07C2102/42C07C2101/14C07C2101/18C07C2101/08C07C2601/04C07C2601/08C07C2601/14C07C2601/18C07C2602/42A61P13/08A61P17/00A61P17/02A61P17/10A61P17/14A61P19/10A61P25/00A61P35/00A61P43/00A61P5/00A61P5/24A61P5/28A61P5/30A61P7/06
Inventor HU, LAIN-YENLEFKER, BRUCE A.DU, DANIEL Y.SMITH, YVONNE DOROTHYLEI, HUANGSHUHARTER, WILLIAM GLENDOWNS, VICTORIA LEIGHBOYS, MARK L.IULA, DONNA MICHELE
Owner PFIZER INC
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