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Mosaic infectious bursal disease virus vaccines

a vaccine and infectious bursal virus technology, applied in the field of biotechnology, can solve the problems of inability or only little of the isolate to infect, multiply or be released, and achieve the effects of reducing cytotoxic and apoptotic effects, positive effect on replication, and profound effect on ibdv viability

Inactive Publication Date: 2007-08-02
STICHTING DIENST LANBOUWKUNDIG ONDERZOEK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides an infectious rIBDV that is incapable of growing in non-bursa cell-derived cells or cells that do not have the necessary receptors for classical or very virulent IBDV. This rIBDV has retained the very virulent characteristics of vvIBDV, including its ability to protect against vvIBDV. The invention also provides a method for obtaining the infectious rIBDV by transfecting a first cell with a nucleic acid or cDNA derived from a vvIBDV and propagating it in a second cell that is permissive for vvIBDV. The rIBDV can also be attenuated by known methods, such as serial passage or site-directed mutagenesis. The vaccine derived from the recombinant virus is safe and effective in protecting against IBDV in poultry.

Problems solved by technology

Essentially incapable of growing herein means that the isolate in question is not or only little capable to infect, multiply or be released for further replication.

Method used

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  • Mosaic infectious bursal disease virus vaccines
  • Mosaic infectious bursal disease virus vaccines
  • Mosaic infectious bursal disease virus vaccines

Examples

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example 1

REFERENCES BELONGING TO EXAMPLE 1

[0264] Azad, A. A., Fahey, K. J., Barrett, S. A., Emy, K. M., and Hudson, P. J. (1986). Expression in Escherichia coli of cDNA fragments encoding the gene for the host-protective antigen of infectious bursal disease virus. Virology 149(2), 190-198. [0265] Been, M. D., Perrotta, A. T., and Rosenstein, S. P. (1992). Secondary structure of the self-cleaving RNA of hepatitis delta virus: applications to catalytic RNA design. Biochemistry 31(47), 11843-52. [0266] Boot, H. J., ter Huurne, A. A., Peeters, B. P., and Gielkens, A. L. (1999). Efficient rescue of infectious bursal disease virus from cloned cDNA: evidence for involvement of the 3′-terminal sequence in genome replication. Virology 265(2), 330-41. [0267] Bottcher, B., Kiselev, N. A., Stel'Mashchuk, V. Y., Perevozchikova, N. A., Borisov, A. V., and Crowther, R. A. (1997). Three-dimensional structure of infectious bursal disease virus determined by electron cryomicroscopy. J. Virol. 71(1), 325-30. [...

example 2

REFERENCES BELONGING TO EXAMPLE 2

[0297] Antin, P. B., and Ordahl, C. P. (1991). Isolation and characterization of an avian myogenic cell line. Dev Biol 143(1), 111-21. [0298] Bayyari, G. R., Story, J. D., Beasley, J. N., and Skeeles, J. K. (1996). Pathogenicity studies of an Arkansas variant infectious bursal disease virus. Avian Dis 40(3), 516-32. [0299] Boot, H. J., ter Huurne, A. A., Peeters, B. P., and Gielkens, A. L. (1999). Efficient rescue of infectious bursal disease virus from cloned cDNA: evidence for involvement of the 3′-terminal sequence in genome replication. Virology 265(2), 330-41. [0300] Britton, P., Green, P., Kottier, S., Mawditt, K. L., Penzes, Z., Cavanagh, D., and Skinner, M. A. (1996). Expression of bacteriophage T7 RNA polymerase in avian and mammalian cells by a recombinant fowlpox virus. Journal of General Virology 77(Pt 5), 963-7. [0301] Brown, M. D., and Skinner, M. A. (1996). Coding sequences of both genome segments of a European “very virulent” infectio...

example 3

REFERENCES BELONGING TO EXAMPLE 3

[0323] Antin, P. B., and C. P. Ordahl. 1991. Isolation and characterization of an avian myogenic cell line. Dev Biol. 143:111-21. [0324] Bayyari, G. R., J. D. Story, J. N. Beasley, and J. K. Skeeles. 1996. Pathogenicity studies of an Arkansas variant infectious bursal disease virus. Avian Dis. 40:516-32. [0325] Boot, H. J., A. A. ter Huurne, B. P. Peeters, and A. L. Gielkens. 1999. Efficient rescue of infectious bursal disease virus from cloned cDNA: evidence for involvement of the 3′-terminal sequence in genome replication. Virology. 265:330-41. [0326] Bottcher, B., N. A. Kiselev, V. Y. Stel'Mashchuk, N. A. Perevozchikova, A. V. Borisov, and R. A. Crowther. 1997. Three-dimensional structure of infectious bursal disease virus determined by electron cryomicroscopy. J Virol. 71:325-30. [0327] Britton, P., P. Green, S. Kottier, K. L. Mawditt, Z. Penzes, D. Cavanagh, and M. A. Skinner. 1996. Expression of bacteriophage T7 RNA polymerase in avian and mamm...

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Abstract

The invention relates to Infectious Bursal Disease Virus (“IBDV”) and vaccines therefor. Provided are infectious recombinant Infectious Bursal Disease Virus (“rIBDV”) essentially incapable of growing in a cell that is not derived from a bursa cell, or an infectious rIBDV having retained at least part of the very virulent characteristics of a very virulent Infectious Bursal Disease Virus (“vvIBDV”).

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a divisional of co-pending U.S. patent application Ser. No. 10 / 046,671, filed Jan. 14, 2002, now U.S. Pat. No. ______, which application is a continuation of International Application Number PCT / NL00 / 00493 filed on Jul. 13, 2000 designating the United States of America, International Publication No. WO 01 / 04319 (Jan. 18, 2001), the contents of the entirety of each of which are incorporated by this reference.STATEMENT ACCORDING TO 37 C.F.R. § 1.52(e)(5)—SEQUENCE LISTING SUBMITTED ON COMPACT DISC [0002] Pursuant to 37 C.F.R. § 1.52(e)(1)(ii), a compact disc containing an electronic version of the Sequence Listing has been submitted concomitant with this application, the contents of which are hereby incorporated by reference. A second compact disc is submitted and is an identical copy of the first compact disc. The discs are labeled “copy 1” and “copy 2,” respectively, and each disc contains one file entitled “Rev. Sequ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12P21/06C12P19/34A61K39/00A61K39/12C07K14/08C12N7/00C12N7/01C12N7/04C12N15/40
CPCA61K39/00C07K14/005C12N2720/10061C12N7/00C07K2319/00
Inventor BOOT, HENDRIK JOHANNISTER HUURNE, ANNA AGNES, H. M.PEETERS, BERNARDUS PETRUS, H.
Owner STICHTING DIENST LANBOUWKUNDIG ONDERZOEK
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