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Method of treating diabetes and obesity using carbohydrate absorption inhibitors

a technology of carbohydrate absorption inhibitor and diabetes, which is applied in the direction of biocide, drug composition, metabolic disorder, etc., can solve the problems that self-control does not always correct the aforementioned metabolic derangement, and achieve the effect of efficiently extracting the effective component, high value-added effective component, and efficiently recycling natural resources

Inactive Publication Date: 2006-02-02
KONISHI YOTARO +5
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0025] Oil obtained from evening primrose seed is widely known. The evening primrose oil contains a large amount of γ-linolenic acid and is said to be effective against obesity, diabetes mellitus, hypercholesterolemia, alcohol dependence, aging, and disease caused by insufficient vitamin B6.
[0026] Also it is widely known that evening primrose oil is effective to inhibit the action in which linolic acid is converted into γ-linolenic acid when virus infection is experienced, as well as to provide a medical treatment for asthma and atopic disease.
[0029] In this invention, a new usage of other components than the fat-soluble component of the evening primrose seed can be provided, and at the same time the effective component can be extracted from the compressed cake after taking out the evening primrose oil. It is significant to extract the high value-added effective component from the compressed cake and efficiently recycle the natural resources.
[0030] To efficiently extract the effective component (polyphenol) for the carbohydrate absorption inhibition, alcohol is used as an extracting solvent for the aforementioned evening primrose seed. Ethanol is especially recommended. If ehanol is used, effective component (polyphenol) is efficiently extracted and can be used both for external application and food. According to other usages available, methanol, butanol or the like can be used.
[0032] Also, alcohol extraction should be repeated preferably at different levels of concentration since the content ratio of polyphenol is improved.

Problems solved by technology

However, such self-control does not always correct the aforementioned metabolic derangement, and medication is very much counted on.
However, it is necessary to consider side effects, dosage and usage of the medicine.

Method used

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  • Method of treating diabetes and obesity using carbohydrate absorption inhibitors
  • Method of treating diabetes and obesity using carbohydrate absorption inhibitors
  • Method of treating diabetes and obesity using carbohydrate absorption inhibitors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0045] Embodiments of this invention are as follows.

(Manufacture of the Carbohydrate Absorption Inhibitor)

[0046] Material: Compressed cake obtained in the manufacturing process of evening primrose oil is used.

[0047] Firstly, the compressed cake was crushed, refluxed by hexane, and then the defatted substance was obtained by removing the remaining oil from the said compressed cake. Secondly, the said defatted substance was fluxed in 70% (v / v) aqueous ethanol, and then the said ethanol extract was evaporated until carbohydrate absorption inhibitor (Embodiment 1) was obtained.

(Inhibitory Activity Against α-Amylase)

[0048] Inhibitory activity (5) of α-amylase in regard to the Embodiment 1 (extract of evening primrose seed) was determined by using an amylase activity measuring kit (“Amylase Test Wako” manufactured by Wako Pure Chemical Industries, Ltd., Japan), which is commercially available. Measuring method using human saliva-derived α-amylase is as follows.

[0049] After incubat...

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Abstract

This invention provides carbohydrate absorption inhibitor derived from evening primrose seed which is significantly effective to prevent and cure diabetes mellitus and prevent obesity, and the manufacturing method of the same. Carbohydrate absorption inhibitor in this invention is characterized that the effective component is an alcohol extract of evening primrose seed. The aforementioned evening primrose seed is preferably a defatted evening primrose seed. Extracting solvent of the aforementioned evening primrose seed is preferably ethanol, or preferably a 70 to 85% (v / v) aqueous ethanol. Also, this invention is characterized that the carbohydrate absorption inhibitor is an effective component of polyphenol derived from evening primrose seed. The polyphenol is preferably one or more substances selected from among gallic acid, ellagic acid, catechin, pentagalloylglucose, procyanidin, and proantocyanidin. The manufacturing method of the carbohydrate absorption inhibitor in this invention is characterized to be composed of the following processes A to C. Process A: evening primrose is compressed, oil is separated then the compressed cake is obtained. Process B: The aforementioned compressed cake is defatted in fat-soluble organic solvent, and defatted substance is obtained. Process C: The aforementioned defatted substance is extracted by alcohol, and then this extracted liquid is concentrated or evaporated.

Description

FIELD OF THE INVENTION [0001] This invention relates to carbohydrate absorption inhibitor and method for manufacturing the same effective against e.g. diabetes prevention, diet, and so forth. BACKGROUND OF THE INVENTION [0002] Polysaccharide (starch, glycogen or the like) contained in food is hydrolyzed by α-amylase in saliva and pancreas and converted into oligosaccharide such as maltose, isomaltose or the like, then decomposed to glucose by disaccharide degrading enzyme such as α-glucosidase or the like in the small intestine and absorbed. [0003] Thus, α-amylase and α-glucosidase perform an important role as a digestive enzyme for carbohydrate in the body. These enzyme activities affect the blood glucose level. Therefore, it is important to control these enzyme activities for the preventions and medical treatments of diabetes mellitus and obesity. [0004] There are two different types of diabetes mellitus. One is insulin-dependent diabetes mellitus (Type I diabetes) and the other i...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/30A61K36/185A61P3/04A61P3/08A61P3/10A61P43/00C07D311/62C07D493/06
CPCA61K36/185C07D493/06C07D311/62A61P3/10A61P3/04A61P3/08A61P43/00
Inventor KONISHI, YOTAROAITANI, MICHIOYAMAGUCHI, HIROSHIARIMURA, TSUTOMUOKADA, TADASHIMURAI, HIROMICHI
Owner KONISHI YOTARO
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