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Two solvent antimicrobial compositions and methods employing them

Inactive Publication Date: 2005-05-05
ECOLAB USA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009] The present invention relates to two solvent antimicrobial compositions and methods employing these two solvent compositions. The two solvent compositions typically contain a second solvent that is not or is only sparingly soluble in a diluting solvent. The two solvent composition can form a clear single-phase solution. The two solvent antimicrobial compositions can reduce the population of microbes on various surfaces such as facilities, containers, or equipment found in food, beverage, or pharmaceutical industries at temperatures between about −70° C. to about 100° C.
[0010] The present invention provides, in one aspect, a method for antimicrobial treatment including applying to microbes a two solvent antimicrobial composition. A two solvent antimicrobial composition can contain a diluting solvent (e.g., water), a second solvent, and optionally, cosolvent, surfactant, or antimicrobial agent, which composition provides greater than a 1-log order reduction in the population of bacteria or spores of Bacillus cereus within 10 seconds at 60° C. In a preferred aspect, the methods of the invention provide broader spectrum antimicrobial action, providing greater than a 1-log order reduction within 10 seconds at 60° C. in one or more organisms such as the mold Chaetomium funicola. In a more preferred aspect, the methods of the invention provide greater than a 1 -log order reduction within 10 seconds at 60° C. in Chaetomium funicola, Bacillus subtilis and Bacillus cereus.

Problems solved by technology

However, these agents sometimes have inadequate activity against bacterial spores, fungal spores, and fungi.
Killing, inactivating, or otherwise reducing the active population of bacterial spores and fungi on surfaces is particularly difficult.
This resistance can be particularly troublesome when the spores or fungi are located on surfaces such as food, food contact sites, ware, hospitals and veterinary facilities, surgical implements, and hospital and surgical linens and garments.
Bacillus cereus is one of the most problematic because Bacillus cereus has been identified as possessing increased resistance to germicidal chemicals used to decontaminate environmental surfaces.
Bacillus cereus is also known to cause serious human illness via environmental contamination.
For example, Bacillus cereus is known to cause post-traumatic injury eye infections, which can result in visual impairment or loss of vision within 12-48 hours after infection.

Method used

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  • Two solvent antimicrobial compositions and methods employing them
  • Two solvent antimicrobial compositions and methods employing them
  • Two solvent antimicrobial compositions and methods employing them

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0192] Several compositions were evaluated by comparing them against a commercially available aseptic bottle washing biocide based on mixed peracids (MATRIXX™; Ecolab). Compositions containing only 1000 ppm or 2000 ppm of a single peracid or mixed peracids were used as controls. The remaining compositions were prepared by adding 10% of various solvents to an aqueous solution containing 1000 ppm or 2000 ppm of the mixed peracids. Non-solubilizing amounts of anionic surfactants were added to some of the compositions to affect minimal coupling and to yield, in some cases, pseudo-stable behavior and at least a partial phase-splitting condition. Addition of such non-stabilizing amounts tended to provide partial coupling and improved antimicrobial solution stability but not necessarily improved microbial control.

[0193] The compositions and controls were evaluated for antimicrobial activity using the procedure set out in set out in Germicidal and Detergent Sanitizing Action of Disinfectan...

example 2

[0196] Several two solvent antimicrobial compositions including diluting solvent and a solvent only partially or sparingly soluble in that solvent were evaluated for biocidal control, using the method of Example 1, and compared to several commercial products and to formulations from several U.S. patents. The compositions of commercial products formed clear (single-phase) formulations when prepared according to instructions. The two solvent antimicrobial compositions including diluting solvent and a solvent only partially or sparingly soluble in that solvent formed pseudo-stable cloudy compositions that underwent phase splitting following application. All tested compositions were evaluated against the spore-forming, enterotoxin producing pathogens Bacillus cereus and Bacillus subtilis and the mold C. funicola using a 10 second contact time at 60° C.

[0197] Set out below in Table II are the run number, benzyl alcohol amount, amounts of additional ingredients, appearance of the mixture...

example 3

[0200] Using the method of Example 1, 5% portions of various sparingly soluble solvents were added to plain water or to commercial peracid bottle washing formulas (KX-6091, 15C, or VORTEXX™; Ecolab) and tested against the mold C. funicola using a 10 second contact time at 60° C. A non-emulsifying amount of the anionic surfactant sodium octene sulfonate was added to some of the compositions to slow down, but not prevent, phase-splitting.

[0201] Set out below in Table III are the run number, solvent, peracid, peracid concentration, surfactant concentration, appearance of the mixtures after they had been allowed to stand for 1 minute, and observed log order reduction for C. funicola for each composition.

TABLE IIIRunPeracidSurfactantC. funicolaNo.SolventPeracidConcentrationConcentrationAppearanceLog Reduction3-1NoneKX-609112000 ppm0ppmclear (1-phase)0.23-2None15C12000 ppm2500ppmclear (1-phase)0.23-3NoneVORTEXX12000 ppm5960ppmclear (1-phase)0.13-4Glycol solvents2KX-609112000 ppm0ppmclo...

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Abstract

The present invention relates to two solvent antimicrobial compositions and methods employing these two solvent compositions. The two solvent compositions typically contain a second solvent that is not or is only sparingly soluble in a diluting solvent. The two solvent composition can form a clear single-phase solution. The two solvent antimicrobial compositions can reduce the population of microbes on various surfaces such as facilities, containers, or equipment found in food, beverage, or pharmaceutical industries at temperatures between about −70° C. to about 100° C.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation-in-part of U.S. patent application Ser. No. 09 / 560,170, filed Apr. 28, 2000, a continuation-in-part of U.S. patent application Ser. No. 09 / 641,775, filed Aug. 18, 2000, and a continuation-in-part of U.S. patent application Ser. No. 09 / 794,790, filed Feb. 27, 2001. The disclosures of each of these applications is incorporated herein by reference.FIELD OF THE INVENTION [0002] The present invention relates to two solvent antimicrobial compositions and methods employing these two solvent compositions. The two solvent compositions typically contain a second solvent that is not or is only sparingly soluble in a diluting solvent. The two solvent composition can form a clear single-phase solution. The two solvent antimicrobial compositions can reduce the population of microbes on various surfaces such as facilities, containers, or equipment found in food, beverage, or pharmaceutical industries at temperatures ...

Claims

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Application Information

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IPC IPC(8): A01N25/02A01N31/02B65D81/28A01N31/04A01N31/14A01N37/04A01N37/16A01N59/00A01N61/00B05D1/32B05D3/06B05D5/00B05D7/00C09D7/00C11D3/20C11D3/39C11D3/43C11D3/48C11D7/50C11D17/00
CPCA01N25/02A01N37/16C11D17/0017C11D7/5022C11D7/265C11D7/263C11D3/48C11D3/43C11D3/3947C11D3/3945C11D3/2075C11D3/2068C11D3/2034C09D7/00B05D7/52B05D5/00B05D3/067B05D1/325A01N61/00A01N59/00A01N25/34A01N25/04A01N2300/00
Inventor HEI, ROBERT D.P.HERDT, BRANDONGRAB, LAWRENCE
Owner ECOLAB USA INC
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