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Andrographolide dispersed tablet

A technology of andrographolide and dispersible tablets, which is applied in the direction of organic active ingredients, medical preparations containing active ingredients, pill delivery, etc., can solve the problems of poor absorption, slow dissolution of andrographolide tablets, and low bioavailability, and achieve Improve the dissolution rate, design a large room for maneuver, reduce the effect of dosage

Inactive Publication Date: 2007-07-04
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dissolution of andrographolide tablets is slow, the absorption is poor, and the bioavailability is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The weight percentage of traditional Chinese medicine extract and auxiliary materials of andrographolide dispersible tablets: fine powder of andrographolide extract 8%, low-substituted hydroxypropyl cellulose 28%, sodium carboxymethyl starch 28%, microcrystalline cellulose 10% , lactose 20%, polyvinylpyrrolidone 3%, magnesium stearate 3%.

[0025] The andrographolide dispersible tablet is obtained according to the following specific steps: the andrographolide is crushed into fine powder, and sieved to obtain the fine powder of the andrographolide extract.

[0026] First pass the above-mentioned materials through a 100-mesh sieve, and mix the fine powder of andrographolide extract, filler and disintegrant according to the method of equal incremental addition. , dissolve in an appropriate amount of water or ethanol to make a soft material; make wet granules through a 20-mesh sieve, dry, granulate through a 20-mesh sieve, add the rest of the auxiliary materials, mix well, ...

Embodiment 2

[0028] Fine powder of andrographolide extract by weight 24%, sodium carboxymethylcellulose 22%, crospovidone 16%, microcrystalline cellulose 14%, polyvinylpyrrolidone 5%, lactose 12%, polyethylene Pyrrolidone 4%, micronized silica gel 1%, magnesium lauryl sulfate 2%. All the other are with embodiment 1.

Embodiment 3

[0030] Fine powder of andrographolide extract by weight 35%, sodium carboxymethyl starch 15%, croscarmellose sodium 20%, crospovidone 6%, low-substituted hydroxypropyl cellulose 4% , mannitol 9%, polyvinylpyrrolidone 7%, micronized silica gel 3%, magnesium stearate 1%, HLB=15-16 sucrose fatty acid ester 1%. Sucrose fatty acid ester is P-1570 or P-1670 or LWA-1570, all the other are the same as embodiment 1.

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PUM

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Abstract

The invention involves andrographolide disintegrating tablet. The invention drugs uses the andrographolide as raw materials, prepares fines of andrographolide extract, adds suitable findings to making andrographolide disintegrating tablet which can collapse completely in 3 minutes and distributes uniformly, and the invention has the effects of heat clearing, detoxicating, antibiosis and anti-inflammation. It can be used for upper respiratory tract infection and bacillary dysentery. The disintegrating tablet can collapse rapid when in water to dissolving into fragrance and sweet solution, so it is easier for patients to accepting and using, and more convenient for bring and use and other features. The preferred findings in the invention can make andrographolide disintegrating tablet collapse more rapidly.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine dispersible tablets, in particular to a dispersible tablet of andrographolide. Background technique [0002] Dispersible tablets are a new drug dosage form developed in recent years. There are many dosage forms of andrographolide, which have the functions of clearing heat, detoxification, antibacterial and anti-inflammatory. For upper respiratory tract infection, bacillary dysentery. Andrographolide, one of the original dosage forms, is a tablet, which has been included in the Chinese Pharmacopoeia. The dissolution of andrographolide tablets is slow, the absorption is poor, and the bioavailability is not high. [0003] Compared with ordinary tablets, dispersible tablets require that the temperature of the disintegration medium is 20±1°C, the disintegration time limit is less than 3 minutes, and all the disintegrated particles should pass through the No. 2 sieve. The drug has the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K9/20A61P31/04A61P1/12
CPCY02A50/30
Inventor 罗晓健王跃生杨世林魏惠珍傅国强王金钱游剑
Owner JIANGXI HERBFINE HI TECH
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