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Composition and application of novel medicine package for preventing and treating women's cervical virus infection

A virus infection and drug package technology, applied in the field of novel drug delivery package, can solve the problems that the drug cannot directly reach the lesion, the drug has a short action time, and the dosage is insufficient, so as to prolong the staying time, promote the repair, and increase the dosage of the drug. accurate effect

Inactive Publication Date: 2007-06-27
北京远策药业有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0083] The purpose of the present invention is to overcome the disadvantages of the current various administration forms in the prevention and treatment of women's cervical virus infection, such as insufficient dosage, short drug action time, inability of the drug to directly reach the lesion, and direct action. Vaginal Medication Pack

Method used

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  • Composition and application of novel medicine package for preventing and treating women's cervical virus infection
  • Composition and application of novel medicine package for preventing and treating women's cervical virus infection
  • Composition and application of novel medicine package for preventing and treating women's cervical virus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] Embodiment 1: The drug delivery package designed according to the anatomical characteristics of female vagina

[0120] Female internal genitalia is composed of vagina, cervix, uterus, fallopian tubes and ovaries, as shown in Figure 2 of the description.

[0121] Vagina: The vagina is cylindrical, a highly expansive, muscular lumen, divided into anterior and posterior walls, with upper and lower ends; the anterior wall is shorter, about 7-9 cm; the rear wall is longer, about 10-12 cm . The upper end is wider and surrounds the cervix. The part surrounding the cervix is ​​called the vaginal vault, which is divided into four parts: front, back, left, and right. The cervix and vagina protrude from the upper end of the vagina, and the lower end opens at the back of the vaginal vestibule, which is narrower than the upper end. Usually, the front and back walls of the vagina are close together, making the cross section of the lower part of the vagina H-shaped. From the vestib...

Embodiment 2

[0125] Embodiment 2: The vaginal administration package we invented contains 1.0ml of the labeled amount of the prescription drug, and the prescription is as follows:

[0126] Recombinant human interferon α2b (Escherichia coli): 3 million IU / ml

[0127] Human Albumin: 0.5%

[0128] Sodium chloride: 0.7%

[0129] Chitosan: 0.1%

[0130] Acetate buffer (pH4.5): 50mM

[0131] Dissolve chitosan, prepare 1% mother solution, and prepare 1M acetate buffer solution (pH4.5), then mix the components according to the prescription concentration, sterilize and filter, and pack until sterilized In the above-mentioned bag containing the drug pack, seal it.

Embodiment 3

[0132] Embodiment 3: Each vaginal administration package contains 1.0ml of the labeled amount of the prescription drug, and the prescription can be as follows:

[0133] Recombinant human interferon beta: 3 million IU / ml

[0134] Human Albumin: 0.5%

[0135] Recombinant Human Interleukin-2 200,000 IU / ml

[0136] Sodium chloride: 0.6%

[0137] Hydroxypropyl methylcellulose: 0.5%

[0138] Citrate buffer (pH5.0): 50mM

[0139] Dissolve hydroxypropyl methylcellulose, prepare 2% mother solution, and prepare 1M citrate buffer solution (pH5.0), then mix the components according to the prescription concentration, sterilize and filter, and pack Put it into the sterilized bag containing the above-mentioned drug pack, and seal it. Embodiment 4: Each vaginal administration package contains 1.0ml of the labeled amount of the prescription drug, and the prescription can be as follows:

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Abstract

The present invention is one novel medicine package for preventing and treating women's cervical virus infection, and the medicine package has novel medicine recipe, novel medicine form and novel medicine transfer device. The medicine package is for treating chronic cervicitis caused by sexually transmitted cervical human papilloma virus (HPV), herpes simplex virus II (HSV-2), cytomegalovirus (CMV), etc and cervical epithelium maldevelopment. It has the functions of inhibiting virus propagation and preventing cervical carcinoma. The present invention has unique medicine recipe, special medicine transfer mode, accurate administration to the pathological cervical part, high local medicine concentration, lasting medicine action period and raised antiviral effect. The cervical Papanicolaou smear examination reveals that the present invention is advance and effective.

Description

Technical field: [0001] The invention relates to the composition and application of a novel drug delivery package for preventing and treating human papillomavirus (HPV), herpes simplex virus type II (HSV-2) and cytomegalovirus (CMV) infection in women. The invention belongs to the field of pharmaceutical preparations with targeted treatment indications. technical background: [0002] 1. Papillomavirus (HPV) infection [0003] Papillomavirus disease is the most common sexually transmitted disease worldwide. It has recently been reported that more than half of adults worldwide are infected with papillomaviruses. There are many types of human papillomavirus (HPV), and more than 100 types have been identified at present. It infects specific parts or causes specific clinical symptoms, and about 30% are transmitted through sex. It has been reported that 77% of HIV-positive women are also HPV-positive. Unlike other sexually transmitted diseases, HPV is easily spread through dir...

Claims

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Application Information

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IPC IPC(8): A61K38/38A61K38/21A61K31/715A61K9/00A61P15/00A61P35/00A61M31/00
Inventor 陈维金张丽兰张莉萍侯云德
Owner 北京远策药业有限责任公司
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