Composition containing rare ginseng saponin, its production and usage

A technology of ginsenosides and total ginsenosides is applied in the directions of medical preparations containing active ingredients, food preparation, drug combination, etc.

Inactive Publication Date: 2013-03-13
WEITAIER HEALTH SCI & TECH KUNMING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method needs to use the organic solvent to extract the ginsenoside diol group as the starting material for hydrolysis, and needs to carry out hydrolysis in the organic solvent system, the process is still relatively complicated, the organic solvent consumption is large, the recovery is difficult, and only 20 (S)- can be obtained. Ginsenoside Rg 3 , the yield can only reach 5-7%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0166] Example 1: Weigh 200 g of ginsenoside powder, fully disperse it with 12,000 ml of 3.0 mol / L dilute acetic acid, heat it to 120°C in a reactor, keep the pressure in the reactor at 7.0MPa, hydrolyze for 40 minutes, and cool down rapidly to 28°C Use 40% sodium hydroxide solution to neutralize the hydrolyzate, filter, collect and dry the solid, and obtain the rare ginsenoside G-Rh 2 and G-Rg 3 Compositions. The composition yield is 41.2%, G-Rh in the composition 2 The content is 11.2%, G-Rg 3 The content is 27.6%. Take 40g of the composition and grind it finely, pass through a 100-mesh sieve, add 600g of sucrose powder passed through a 100-mesh sieve, 1200g of lactose, 150g of microcrystalline cellulose, and 10g of vanillin, mix well, and granulate with an appropriate amount of 10% starch slurry. Dried, divided into 1000 parts, made into granule medicine or functional food.

Embodiment 2

[0167] Example 2: Weigh 200g of notoginsin powder, fully disperse it with 10,000ml of 0.5mol / L dilute hydrochloric acid, heat it to 90°C in a reactor, keep the pressure in the reactor at 2.0MPa, hydrolyze for 120 minutes, and rapidly cool down to 28 After ℃, use 40% sodium hydroxide solution to neutralize the hydrolyzate, filter, collect and dry the solid, and obtain the rare ginsenoside G-Rh 2 and G-Rg 3 Compositions. The yield of the composition is 33.2%, and the G-Rh in the composition 2 The content is 9.1%, G-Rg 3 Content 22.8%. Take 38g of the composition, grind it finely, pass through a 80-mesh sieve, add 200g of medicinal starch, granulate with 10% starch slurry, dry, and after granulation, add 3g of magnesium stearate, mix well, and fill in 1 # Capsules, made 1000, made into capsule medicine or functional food.

Embodiment 3

[0168] Example 3: Weigh 200g of American ginseng total glycoside powder, fully disperse it with 15000ml of 1.0mol / L dilute citric acid, heat it to 135°C in a reactor, keep the pressure in the reactor at 4.0MPa, hydrolyze for 270 minutes, and rapidly cool down to 28°C. After ℃, use 40% sodium hydroxide solution to neutralize the hydrolyzate, filter, collect and dry the solid, and obtain the rare ginsenoside G-Rh 2 and G-Rg 3 Compositions. The composition yield is 40.5%, G-Rh in the composition 2 The content is 11.9%, G-Rg 3 Content 32.6%. Take 27g of the composition, grind it finely, pass through a 100-mesh sieve, add 40g of starch, 75g of lactose, 8g of microcrystalline cellulose, and 2.5g of cross-linked carboxymethylcellulose, and mix it with an appropriate amount of 3% carboxymethylcellulose solution. Granules, dried, granulated, added 1.5g of magnesium stearate, 2g of micropowdered silica gel, mixed evenly, and pressed into 1000 plain tablets with an 8mm die.

[0169]...

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PUM

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Abstract

The invention provides a composition, the application and the preparation technique thereof. The composition is in the form of powder, particle, capsule, tablet, oral liquid, and the like, which is used for preventing and treating cardiovascular and cerebrovascular diseases, nerve cell injury, and cancer, delaying sanility, and relieving fatigue. The composition contains ginsenoside Rh2 and Rg3 (5-49.9 Wt%) in the weight ratio of 1: (0.1-8).

Description

technical field [0001] The present invention relates to a kind of rare ginsenoside-Rh 2 and -Rg 3 The composition of this composition, the application of this composition and preparation technology thereof. Background technique [0002] Araliaceae (Araliaceae) Panax plants, such as Panax ginseng (P.ginseng), American ginseng (P.quenquefolinus), Panax notoginseng (P.notoginseng), bamboo ginseng (P.uaponicus), Cucurbitaceae Jiaogulan plants Gynostemma pentaphyllum Thrunb Mak, etc. are commonly used medicinal plants in my country, and their main active ingredients are ginsenosides. There are 42 kinds of ginsenosides that have been found, which are divided into three types: panaxadiol glycosides, panaxatriol glycosides, and oleanolic acid saponins. The aglycones in each group were the same, but the sugar chains were different. [0003] Rare ginsenoside Rh in the ginsengdiol glycoside group 2 and Rg 3 Both are trace components isolated from red ginseng by Japanese scholar Ki...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K31/7048A61P25/00A61P9/00A61P35/00A61P39/06A61P43/00A23L1/30A23L33/105
Inventor 刘学系韩颖王曙彩王娟陈锡强高心湘
Owner WEITAIER HEALTH SCI & TECH KUNMING
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