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Motherwort injection

A technology of injection and motherwort, applied in the field of high-quality motherwort injection, to achieve the effect of less particles, improved performance index and improved quality

Active Publication Date: 2007-06-06
CHENGDU FIRST PHARMACEDTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the diversity of traditional Chinese medicine varieties, there is still a very difficult way to go to realize the fingerprint technology and actually apply it to the industrial production of a specific Chinese medicinal material product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1 Preparation of Motherwort Injection

[0061] Take motherwort and add water to decoct three times, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.36-1.38 (80°C), add water to dilute to a water content of about 35%, and use 88%-95% ethanol respectively Extract three times, stand still, filter, recover ethanol, add activated carbon (consumption is 0.1%) and sterilized activated talc: diatomite (1:1) adsorbent (consumption is 1%) mixture decolorization After the solution is colorless or light yellow and stored for 24 hours, add water for injection to make 1ml contain about 20mg of total alkaloids, decarburize and adsorbent, fine filter, potting, and sterilize to obtain Motherwort Injection. According to spectrophotometry (appendix VB), measure at D525nm wavelength place, biological total alkaloid content is 20mg / ml in terms of stachydrine hydrochloride, adopts the HPLC method measurement that provid...

Embodiment 2

[0068] Example 2 Preparation of Motherwort Injection

[0069] Take motherwort and add water to decoct three times, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.36-1.38 (80°C), add water to dilute to a water content of about 35%, and use 88%-95% ethanol respectively Extract three times, stand still, filter, recover ethanol, add activated carbon (consumption is 0.5%) and contain sterilized activated talc: diatomite (1:1) adsorbent (consumption is 3%) mixture liquid Decolorize until the solution is colorless or light yellow, and store it for 24 hours, add water for injection to make 1ml contain about 20mg of total alkaloids, decarburize and adsorbent, filter finely, potting, and sterilize to obtain Motherwort Injection. According to spectrophotometry (appendix VB), measure at D525nm wavelength place, biological total alkaloid content is 20mg / ml in terms of stachydrine hydrochloride, adopts the HPLC method measuremen...

Embodiment 3

[0076] Example 3 HPLC detection of motherwort injection stachydrine hydrochloride

[0077] (1) Experimental instruments and reagents

[0078] (1) Instrument:

[0079] Waters717-Waters2487-M32 workstation

[0080] Waters2690-Waters2487-M32 Workstation

[0081] Chromatographic column: Alltech SCX 5μ (4.6×250mm)

[0082] Phenosphere SCX 5μ (4.6×250mm)

[0083] MILLIPORE Ultrapure Water Preparation Apparatus

[0084] (2) test drug

[0085] The samples were provided by Chengdu Times First Drug Research Institute Co., Ltd.

[0086] Reference substance National Institute for the Control of Pharmaceutical and Biological Products (Stahydrine Hydrochloride, batch number: 712-9903, for content determination)

[0087]Reagent Potassium dihydrogen phosphate was produced by Chengdu Chemical Reagent Factory, water was ultrapure water, and other reagents were of analytical grade.

[0088] (2) Chromatographic conditions

[0089] (1) Detection wavelength: 203nm.

[0090] (2) Analytical...

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Abstract

The present invention relates to high quality motherwort injection and its preparation process. The present invention proposes the HPLC fingerprint standard, and has determined characteristic matters in motherwort injection, optimized technological process, raised injection consistency and high and stable product quality.

Description

technical field [0001] The invention relates to a high-quality motherwort injection. Background technique [0002] Due to the influence of factors such as seeds, places of origin, growth conditions, and harvesting dates, Chinese herbal medicines often have great differences in their quality, as well as in the composition and proportion of internal substances; The influence of medicinal materials, the rationality and fluctuation of process parameters also seriously affect the consistency of internal components and composition ratios. Due to these uncontrollable factors, some traditional Chinese medicine products, especially traditional Chinese medicine injections, have great differences between the same variety of traditional Chinese medicine injections in different production periods. In recent years, due to the substantial increase in people's awareness and consumption of medicines, the negative evaluation of Chinese medicine injections has been on the rise, and Chinese me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/533A61K9/08A61P15/00A61P13/12G01N30/02
Inventor 刘仲义吴大蓉李长富曾智辉
Owner CHENGDU FIRST PHARMACEDTICAL CO LTD
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