Dry coating sustained-release tablet for treating arthritis and preparation process thereof

A controlled-release tablet and arthritis technology, which is applied in the field of traditional Chinese medicine preparations, can solve the problems of drug bioavailability reduction, enhancement of drug side effects, and strengthening, so as to reduce the number of administrations and doses, reduce the amount of tripterygium glycosides, reduce The effect of dosage

Inactive Publication Date: 2007-05-30
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing drug dosage forms cannot meet the above-mentioned drug administration requirements, resulting in the accumulation and strengthening of the toxic and side effects of the drug. Impaired renal function, etc.
For example, the oral dosage form of Tripterygium wilfordii currently used in clinical practice needs to be taken 3-4 times a day, and the blood drug concentration fluctuates greatly, which cannot guarantee effective blood drug concentration at the required time, and cannot overcome the toxic and side effects on the gastrointestinal tract; Although the release tablet preparation can maintain the steady-state blood drug concentration for a long time, it cannot meet the characteristic needs of patients with rhythmic seizures, and it is easy to develop tolerance, enhance the toxic and side effects of the drug on the human body, and reduce the bioavailability of the drug.

Method used

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  • Dry coating sustained-release tablet for treating arthritis and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1. Preparation prescription:

[0035] Dry coating: 110 parts of PEG6000, 110 parts of hydrogenated castor oil (HCO), 15 parts of ethyl cellulose (EC).

[0036] Drug tablet core: 25 parts of tripterygium glycosides, 15 parts of microcrystalline cellulose, 35 parts of pregelatinized starch, 25 parts of methyl cellulose, appropriate amount of magnesium stearate, and appropriate amount of lactose.

[0037] 2. Preparation method:

[0038] 1), weigh tripterygium glycosides, microcrystalline cellulose, pregelatinized starch, methyl cellulose and lactose according to the prescription amount (the loss should be increased according to the size of the preparation amount), pass through a 60 mesh sieve and mix three times, add pregelatinized starch A mixed binder of gelatinized starch and methyl cellulose is used to make soft materials. Pass through a 20-mesh sieve to granulate, and dry at 55°C for 60 minutes. Pass through a 20-mesh sieve for granulation. Add an appropriate amou...

Embodiment 2

[0042] 1. Preparation prescription:

[0043] Dry coating: 120 parts of PEG6000, 110 parts of hydrogenated castor oil (HCO), 15 parts of ethyl cellulose (EC).

[0044] Drug tablet core: 25 parts of tripterygium glycosides, 15 parts of microcrystalline cellulose, 35 parts of pregelatinized starch, 25 parts of methyl cellulose, appropriate amount of magnesium stearate, and appropriate amount of lactose.

[0045] 2. Preparation method:

[0046] 1), weigh tripterygium glycosides, microcrystalline cellulose, pregelatinized starch, methyl cellulose and lactose according to the prescription amount (the loss should be increased according to the size of the preparation amount), pass through a 60 mesh sieve and mix three times, add pregelatinized starch A mixed binder of gelatinized starch and methyl cellulose is used to make soft materials. Pass through a 20-mesh sieve to granulate, and dry at 55°C for 60 minutes. Pass through a 20-mesh sieve for granulation. Add an appropriate amou...

Embodiment 3

[0050] 1. Preparation prescription:

[0051] Dry coating: 110 parts of PEG6000, 100 parts of hydrogenated castor oil (HCO), 10 parts of ethyl cellulose (EC).

[0052] Drug tablet core: 30 parts of tripterygium glycosides, 10 parts of microcrystalline cellulose, 30 parts of pregelatinized starch, 30 parts of methyl cellulose, appropriate amount of magnesium stearate, and appropriate amount of lactose.

[0053] 2. Preparation method:

[0054] 1), weigh tripterygium glycosides, microcrystalline cellulose, pregelatinized starch, methyl cellulose and lactose according to the prescription amount (the loss should be increased according to the size of the preparation amount), pass through a 60 mesh sieve and mix three times, add pregelatinized starch A mixed binder of gelatinized starch and methyl cellulose is used to make soft materials. Pass through a 20-mesh sieve to granulate, and dry at 55°C for 60 minutes. Pass through a 20-mesh sieve for granulation. Add an appropriate amou...

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Abstract

The invention discloses a kind of dry dressed controlled release tablets for treating arthritis which comprises medicinal cores and dry coating sheet, wherein the dry coating sheet comprises slow release matrix material 110-150 parts, hole-making agent 100-120 parts, right amount of binding agent and magnesium stearate. The medicinal cores comprise Tripterygium wilfordii glycosides 20-30 parts, crumbling agent 10-20 parts, bonding agent 20-30 parts, thinning agent 30-40 parts, and right amount of magnesium stearate.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a dry-coated controlled-release tablet and a preparation method of the dry-coated controlled-release tablet. Background technique [0002] The clinical manifestations of rheumatoid arthritis are swelling, pain, stiffness, and deformation of limb joints. If not treated in time, it will lead to joint deformity or even disability, which will seriously affect the quality of life of patients. The disease has a high incidence rate and is protracted and intractable. Western medicines for rheumatoid arthritis are divided into "third-line" medicines. Non-hormonal anti-inflammatory drugs are called "first-line" drugs, which mainly achieve anti-inflammatory and analgesic effects by inhibiting the synthesis of prostaglandins. In addition, such drugs can still inhibit phosphodiesterase to increase intracellular cAMP, increase the stability of lysosomal membranes, and reduce the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61K31/7048A61K9/22A61K47/38A61K47/44A61P19/02A61P29/00
Inventor 刘强
Owner SOUTHERN MEDICAL UNIVERSITY
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