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Simplified thin-layer liquid-based cytology cell smeard preparation method

A cell smear and liquid-based cell technology, applied in the field of cytological examination, can solve the problems of expensive equipment and reagent consumables, unsuitable for mass census and physical examination, difficult to carry out, etc., achieving low cost, protecting the working environment and staff. Health, the effect of low missed diagnosis rate

Inactive Publication Date: 2010-05-12
绵竹市人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the equipment, reagents, and consumables used in this method are relatively expensive, and it is difficult to carry out in ordinary hospitals, and it is not suitable for mass censuses and physical examinations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0029] Embodiment 2 comparative test

[0030] After hundreds of clinical studies, the sensitivity is 91.6%, and the negative predictive value reaches 98.7%. The positive detection rate is higher than that of ordinary Pap smears (p<0.05), so it is suitable for large-scale gynecological general examinations, physical examinations, and cytology examinations in primary hospitals. Its low fees can reduce the burden on patients. See Table 1 and Table 2.

[0031] Table 1209 Cases of Simple Liquid-Based Cytology Examination Results Comparison with Common Pap Smear Examination Results

[0032]

ASCUS%

LSIL%

HSIL%

Pathogen +%

Liquid-based film production

13 cases 6.2

6 cases 2.8

4 cases 1.9

5 cases 2.3

traditional pap

8 cases 3.8

4 cases 1.9

3 cases 1.4

0 cases

[0033] Table 2 Comparison of smear quality

[0034] Quantitative indicators

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PUM

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Abstract

The invention discloses a simple thin liquid-based cytology examine method applied for the gynecological examination, the cervical cancer general examine and the cervical cancer preceding lesion of selected crowd, the steps including: using the cervical cells brush and the scraper to collect samples, put samples in the liquid-based cell preservation solution, add base liquid cell processing solution, oscillate, centrifugally separate, take and discard the supernatant samples liquid, using adding samples gun to assimilate sediment samples, smear, sheet drying, using 95% ethanol marinate or spray for fixed, washing and dyeing. The invention has simple method, small steps, high positive detection rate, low misdiagnosis rate, low cost, and it can effectively eliminate the red blood cells, mucus and other interference components from the cervical cytology detection specimens, with good sheet-producing result.

Description

technical field [0001] The invention relates to a cytological examination method, in particular to a simple thin-layer liquid-based cytological examination method that can be used for gynecological physical examination, cervical cancer screening and screening of cervical precancerous lesions in crowds. Background technique [0002] There are 500,000 new cases of cervical cancer every year in the world, and China accounts for 1 / 4 and shows an upward and younger trend. Cervical cancer is the only malignant tumor in the human body that can be diagnosed early by screening, find out precancerous lesions (intraepithelial neoplasia), and be 100% cured. Therefore, it is of great clinical significance and application value to develop a thin-layer liquid-based cytology examination method with simple method, low cost, high accuracy, specificity and sensitivity for general screening and physical examination. [0003] The traditional ordinary Pap smear has a 15% to 20% missed diagnosis ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N1/30G01N1/28C12Q1/02A61B10/02
Inventor 邱瑞成
Owner 绵竹市人民医院
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