Application of honokiol in preparing sensitization agent for tumour chemotherapy

Abstract

An application of honokiol (C18H18O2) along with its pharmacologically acceptable excipient or carrier in preparing the sensitizer for the chemicotherapy of cancer is disclosed. Said sensitizer is almost non-toxic to the normal cells of human body.

Description

technical field [0001] The invention belongs to the application of natural plant monomer compounds, and relates to the new application of honokiol extracted from plants, in particular to the application of honokiol in the preparation of common chemotherapy drugs as tumor chemotherapy sensitizers. Background technique [0002] Chemotherapy (chemotherapy) is one of the main treatment methods for cancer. For half a century, tumor chemotherapy has developed rapidly. Currently, chemotherapy alone can cure choriocarcinoma, testicular seminoma, acute lymphoblastic leukemia, etc. , Long-term remission can be obtained for some tumors, such as breast cancer, Wilms tumor, granulosa cell leukemia, etc. However, while improving the cure rate and quality of life of cancer patients, chemotherapy will inevitably produce many adverse reactions, such as kidney disease. Toxicity, cardiotoxicity, bone marrow toxicity, etc. [0003] Common chemotherapeutic drugs such as doxorubicin and daunorub...

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Problems solved by technology

[0002] Chemotherapy (chemotherapy) is one of the main treatment methods for cancer. For half a century, tumor chemotherapy has developed rapidly. Currently, chemotherapy alone can cure choriocarcinoma, testicular seminoma, acute lymphoblastic leukemia, etc. , Long-term remission can be obtained for some tumors, such as breast cancer, Wilms tumor, granulosa cell leukemia, etc. However, while improving the cure rate and quality of life of cancer patients, chemotherapy will inevitably produce many adverse reactions, such as kidney disease. Toxicity, cardiotoxicity, bone marrow toxicity, etc.

[0003] Common chemotherapeutic drugs such as doxorubicin and daunorubicin will cause certain cardiotoxicity after being applied to the human body: it can cause sudden tachycardia, acute heart failure, dyspnea, etc., to some extent, anthracene The cardiotoxicity of cyclic antibiotics has become the main factor that limits the dosage of drugs used in chemotherapy; paclitaxel can cause allergic reactions, and reactions such as urticaria, respiratory distress, and hypotension can occur after medication; etoposide can cause severe bone marrow suppression, resulting in granulocytopenia or even deficiency);

[0004] In the clinical chemotherapy of malignant tumor patients, in order to kill tumor cells to the greatest extent and improve the therapeutic effect, the dose of drugs given is generally the "maximum tolerable dose". Therefore, the toxic and side effects of chemotherapy drugs have become It is an important factor that restricts the dosage of chemotherapy drugs and thus restricts the effect of clinical chemotherapy.

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