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Nano target medicine for magnetothermal therapy of malignant tumor

A technology of malignant tumor and magnetic hyperthermia, which is used in anti-tumor drugs, drug combinations, inorganic non-active ingredients and other directions to achieve the effect of curing malignant tumors, killing cancer cells and facilitating storage.

Active Publication Date: 2007-04-25
朱宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, magnetic thermal seeds still need to be introduced into tumor lesions by implantation, local injection, etc. in magnetic hyperthermia, and it has not been seen to couple antibodies or ligands with magnetic thermal seeds (i.e., nano-magnetic powder) to make active magnetothermal therapy. Targeted drugs and the use of the magnetic properties of magnetothermal seeds to make magnetically targeted drugs for magnetic hyperthermia and use the active and magnetic targeting functions of drugs to target drugs into tumor lesions for magnetic hyperthermia treatment of malignant tumors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Fe with a particle size distribution range of 1-5nm, 10-20nm and 20-40nm, 50-100nm, 350-390nm or 950nm 2 o 3 or Fe 3 o 4 Or Fe nano-magnetic powder was added to the sodium oleate aqueous solution whose mass ratio of nano-magnetic powder and sodium oleate was 1:0.0001, 1:0.05, 1:0.20 respectively, ultrasonically mixed for 10 min, placed in a water bath at 85°C and stirred at 600r / min for 8 Hours, after centrifugation, removing the supernatant, and fully washing with deionized water, the nanometer magnetic powder modified by sodium oleate is obtained.

Embodiment 2

[0038] Fe with a particle size distribution range of 5-10nm, 50-100nm, 200-300nm or 950nm 2 o 3 or Fe 3 o 4 Or Fe nano-magnetic powder was added to the n-decanoic acid aqueous solution with the mass ratio of nano-magnetic powder and n-decanoic acid respectively 1:0.0001, 1:0.01, 1:0.20, ultrasonically mixed for 10 minutes, placed in a 70°C water bath and stirred at 1000r / min for 6 Hours, centrifuged to remove the supernatant, and fully washed with deionized water to prepare n-decanoic acid-modified nano magnetic powder.

Embodiment 3

[0040] Fe with a particle size distribution range of 30-50nm, 40-80nm, 50-100nm or 250-350nm 2 o 3 or Fe 3 o 4 Or Fe nano magnetic powder was added to the sodium lauryl sulfate aqueous solution with the mass ratio of nano magnetic powder and sodium lauryl sulfate being 1:0.0001, 1:0.01, 1:0.20 respectively, ultrasonically mixed for 10min, and placed in a water bath at 80°C Stir at 800r / min for 1 hour, centrifuge, remove the supernatant, and wash thoroughly with deionized water to obtain sodium dodecyl sulfate modified nano-magnetic powder.

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Abstract

The invention relates to a method for preparing the nanometer target drug used to treat cancer. Wherein, it is a nanometer magnetic-antibody / ligand drug and nanometer magnetic target drug used in cancer magnetic thermal treatment, with high specific thermal power; it comprises 1:0.0001-0.20 effective molecule and guide molecule, while the effective molecule is magnetic powder whose diameter is lower than 1000nm, and the specific thermal power SAR is 10-7000W / gFe; the guide molecule comprises antibody or ligand or magnetic powder; the diameter of target drug is 2-1000nm; the preparation comprises that coupling the magnetic powder and guide molecule in water, organic or inorganic mixture. The inventive drug can effective kill cancer cell and treat cancer.

Description

technical field [0001] The invention relates to a nano-targeted drug for magnetic hyperthermia therapy of malignant tumors and its preparation method and application, that is, a nano-magnetic powder-antibody / ligand targeted drug and nano-magnetic powder for magnetic hyperthermia therapy of malignant tumors with high heat-generating specific power Magnetically targeted drugs. Background technique [0002] In 2000, there were about 10 million new cases of malignant tumors in the world, 6.2 million deaths, and 22 million current cases. It is estimated that in 2020, there will be 15 million new cases of malignant tumors, 10 million deaths, and 30 million existing cases. Malignant tumors are becoming the number one killer of human beings in the new century, and will cause huge losses to the global social economy. It is of great significance to carry out research on new drugs and new treatment methods for malignant tumors. [0003] Traditional malignant tumor treatment methods a...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61K47/02A61P35/00
Inventor 朱宏
Owner 朱宏
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