A liquid capsule of 'She Dan Chuan Bei' and preparation method thereof

Abstract

Disclosed is a liquid capsule for treating wind-heat and cough and its preparing process, wherein the capsule comprises hard gelatin capsule shell and content prepared from the following raw materials (by weight portions): snake bile 44-54 parts, Sichuan fritillary bulb 265-325 parts, and polyethylene glycols 400 378-462 parts. The preparing process comprises the steps of disintegrating Sichuan fritillary bulb into fines, mixing with snake bile juice homogenously, drying, disintegrating into fines, charging right amount of polyethylene glycol 400 and water.

Description

technical field [0001] The invention relates to a preparation method of a liquid capsule, in particular to a preparation method of a Shedan Chuanbei liquid capsule for treating wind-heat cough. Background technique [0002] Shedan Chuanbei Powder, Shedan Chuanbei Liquid and Shedan Chuanbei Capsules are currently one of the commonly used Chinese patent medicines used to treat cough and phlegm. The prescription contains Chinese medicines such as Chuan Fritillaria and Shedan, which have the functions of dispelling wind, relieving cough, removing phlegm and dispelling stagnation It can be used to treat wind-heat cough, asthma with phlegm, chest tightness, bad cough or chronic cough. The Chinese Pharmacopoeia 2005 Edition contains Shedan Chuanbei Powder, Ministry-issued Traditional Chinese Medicine Prescriptions (Volume 9) contains Shedan Chuanbei Liquid, and Ministry-issued Traditional Chinese Medicine Prescriptions (Volume 6) contains Shedan Chuanbei Powder capsule. [0003] ...

AI Technical Summary

Problems solved by technology

[0003] Shedan Chuanbei Powder is directly crushed into medicine without extraction, so it has the disadvantages of large dosage, slow onset of action, easy growth of microorganisms, and relatively short validity period.

[0004] Because Shedan Chuanbei liquid is a syrup, there are disadvantages such as complicated process, large dosage, and inconvenient transportation; and because of its high sugar content, it is easy to breed microorganisms and has a short validity period, and it is not suitable for patients who need to prohibit or control sugar intake (such as Diabetics) should not be used

[0005] Shedan Chuanbei Capsules have the following disadvantages: the process is complicated; the disintegration is relatively slow, generally over 15 minutes, which affects its bioavailability to a certain extent, and the onset of action is slow; the dosage is relatively large

However, the composition of various traditional Chinese medicine preparations is complex, and the selection and dosage of the monarch drug, ministerial drug, and auxiliary materials have a direct impact on the efficacy of the medicine. key to craftsmanship

[0007] The invention patent application with the publication number CN1814156 discloses a liquid capsule for treating lung-heat cough and excessive phlegm and its preparation method, but the drying temperature of snake bile is 80°C and the drying time is not clearly stated, "Taurine in snake bile Comparative Study on the Determination Methods of Cholic Acid Content" (Chinese Journal of Modern Applied Pharmacy, Volume 17, Issue 3, June 2000) and "Studies on the Stability of Sodium Taurocholate in Different Media and During Sterilization" (Chinese Traditional Medicine Magazine 1999 the 24th volume No. 2 period) has explained that the main medicinal composition in snake gallbladder is taurocholic acid and taurocholic acid is placed at too high temperature for a long time and can cause taurocholic acid to go bad, thereby has affected the drug efficacy

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