Composition for losing weight

A technology of composition and use, which is applied in the direction of drug combination, medical preparations containing active ingredients, metabolic diseases, etc., can solve the problems of poor solubility of berberine hydrochloride and berberine tannin, etc., achieve rich sources of drugs and lower serum cholesterol , low cost effect

Inactive Publication Date: 2007-04-04
吴林根
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the solubility of berberine hydrochloride and berberine tannate is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A composition for weight loss, comprising berberine and oryzanol, the weight ratio of berberine and oryzanol is 8.1:1, 8.2:1, 8.3:1, 8.4:1, 8.5:1, and the consumption of oryzanol is 180-300 mg / person. day.

[0020] In this example, the berberine is berberine hydrochloride or berberine tannin, which can be commercially available berberine hydrochloride or berberine tannin, or berberine hydrochloride or berberine tannin prepared by known methods. Berberine, however, does not include berberine sulfate, phosphoric acid, or citrate.

[0021] In this embodiment, the excipients or carriers are commonly used excipients or carriers in the field of pharmacy or food, such as diluents, disintegrants, lubricants and the like.

[0022] The composition for weight loss described in this embodiment can be used as a medicine for preventing diseases or symptoms related to obesity, such as cardiovascular and cerebrovascular diseases and diabetes symptoms, such as: fatty liver, elevated b...

Embodiment 2

[0024] A composition for weight loss, comprising berberine and oryzanol, the weight ratio of berberine and oryzanol is 8.30:1, 8.31:1, 8.32:1, 8.33:1, 8.34:1, 8.35:1, 8.36:1, 8.37: 1, 8.38:1, 8.39:1, the dosage of oryzanol is 180-300 mg / person.day.

[0025] Berberine hydrochloride was used to follow up and monitor 60 patients with hyperlipidemia. It was found that while blood lipids decreased, the weight of the patients was also significantly reduced. In patients with hyperlipidemia in this group, the body mass index was greater than or equal to Among the 35 patients in 25 cases, the body weight of 29 patients decreased from 71.41±2.08 kg to 66.93±1.9 kg (range 2-12.5 kg). The statistical difference was particularly significant (P<0.001), and the decline rate reached 83%. Among them, 19 cases lost weight equal to or more than 5 kg, accounting for 66% of the 29 cases with weight loss effect. Of the 25 patients with a BMI less than 25, 2 patients lost 1.5-2 kg. The drop rate i...

Embodiment 3

[0029] A composition for weight loss of the present invention, the weight ratio of berberine and oryzanol is 8.20:1, 8.21:1, 8.22:1, 8.23:1, 8.24:1, 8.25:1, 8.26:1, 8.27:1, 8.28 : 1, 8.29: 1, the consumption of oryzanol is 180~300 mg / person. day, berberine is berberine hydrochloride or berberine tannin, can be commercially available berberine hydrochloride or berberine tannin, also can be according to Berberine hydrochloride or berberine tannin prepared by known methods, however, excluding sulfuric acid, phosphoric acid or berberine citrate.

[0030] The weight loss composition described in this example is used to prepare a medicine for preventing diseases or symptoms related to obesity, such as cardiovascular and cerebrovascular diseases and diabetes symptoms, such as: fatty liver, elevated blood pressure, elevated blood sugar, coronary Heart disease, myocardial infarction, stroke, etc.

[0031] In this embodiment, the added excipients or carriers are commonly used excipient...

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PUM

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Abstract

A medical composition for losing weight and preventing and treating the diseases associated with obesity is prepared from berberine and oryzanol in weight ratio of (8-8.5):1.

Description

technical field [0001] The composition for weight loss of the invention relates to a composition prepared by combining berberine and oryzanol for weight loss, and also relates to the composition being used for treating obesity and related diseases. technical background [0002] Berberine is an isoquinoline alkaloid extracted from the rhizome of Coptis genus of Ranunculaceae. Shigella has the strongest effect and is often used to treat digestive tract diseases such as bacterial gastroenteritis and dysentery. Because of poor oral absorption, berberine is traditionally used as an antibiotic for the treatment of intestinal infectious diseases. Oryzanol is often used for diseases such as autonomic dysfunction, premenstrual tension disorder and menopausal syndrome, such as: gastric ulcer, irritable bowel syndrome, chronic gastritis, gastroptosis. [0003] However, berberine hydrochloride and berberine tannin have poor solubility. [0004] In animal experiments in 2006, Korean s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P3/04A61K31/4375
Inventor 吴林根
Owner 吴林根
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