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Compound with anti cerebralischemia, myo cardialischemia and memory-improving functions, and its preparing method and use

A technique for myocardial ischemia and anti-cerebral ischemia, applied in the field of medicine, can solve the problems of difficult operation of the treatment method, side effects such as drug bleeding, unsatisfactory curative effect, etc., and achieve good myocardial ischemia and good anti-cerebral ischemia. Effect, improve memory and get bad effect

Inactive Publication Date: 2007-03-28
闫福林 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] There are many existing anti-ischemic drugs, such as thrombolysis, antithrombotic, and exogenous neurotrophic factors. Although some successful progress has been made in the treatment, most drug treatments still have many defects, such as: The molecular weight of the drug is large, and it is difficult to play a role through the blood-brain barrier; some drugs are prone to side effects such as bleeding; some treatment methods are difficult to operate, and the curative effect is not satisfactory, etc.
In addition, there is currently a lack of very effective anti-myocardial ischemia and memory-improving drugs

Method used

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  • Compound with anti cerebralischemia, myo cardialischemia and memory-improving functions, and its preparing method and use
  • Compound with anti cerebralischemia, myo cardialischemia and memory-improving functions, and its preparing method and use
  • Compound with anti cerebralischemia, myo cardialischemia and memory-improving functions, and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 3 kg of dried and pulverized chrysanthemum root, soak 3 times with 9L ethanol at room temperature, each time for 5 days, extract 200 g by distillation under reduced pressure to obtain 200 g of extract, use 200-300 mesh silica gel column chromatography, chloroform / methanol ( 10:1) was used as the eluent and monitored by thin layer chromatography to obtain 4.5 g of the compound of the following formula with a purity of not less than 99%.

[0016]

[0017] Compound spectral data are as follows:

[0018] Amorphous powder, molecular formula C 21 h 32 o 9 ;[α] D 23 +22°.62(c 0.97, CH 3 OH);

[0019] IR ν max / cm -1 : 3400, 1760, 1640.

[0020] 1 HNMR (400MHz, CH 3 OH): 5.01 (1H, dd, J=11, 6H z , 1-H), 4.54 (1H, dd, J=13, 7H z , 3-H), 4.94 (1H, br d, J=10H z 5-H), 1.21 (3H, d, J=7H z 13-H), 4.19 (1H, br d, J = 7.6H z 14-H), 1.65 (3H, br s, 15-H).

[0021] 13 CNMR: (100MHz, CH 3 OH): 127.6(C-1), 32.2(C-2), 83.0(C-3), 141.0(C-4), 127.4(C-5), 81.5(C...

Embodiment 2

[0023] Tablets: active ingredient 300mg

[0024] Lactose 124mg

[0025] MCC 46mg

[0026] Magnesium Stearate 4mg

[0027] Mix the active ingredients, lactose and MCC evenly, moisten with water, sieve the wetted mixture and dry, sieve, add magnesium stearate, mix evenly, and press into tablets.

Embodiment 3

[0029] Capsules: active ingredient 300mg

[0030] Lactose 87mg

[0031] Magnesium Stearate 5mg

[0032] Mix the active ingredients and lactose evenly, moisten with water, sieve and dry the wetted mixture, sieve, add magnesium stearate, mix evenly, and pack into capsules.

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PUM

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Abstract

The invention provides a compound for resisting ischemia and myocardial ischemia and improving meromorphic function, adopting the roots of Pterocypsela elata, Pterocypsela laciniata and other Pterocypsela plants as raw materials, soaking with solvent at room temperature, vacuum-distilling the extractive, and making repeated silica gel column chromatography on the obtained extract and making it. And it and the pharmaceutically acceptable carriers can be made into tablets, capsules, soft capsules, pill drops, granules, oval solution, and syrups or injections. And it can reduce the water content of brain tissue, reduce the MDA and NO contents of ischemic brain tissue and the MDA content of meromorphic tissue, and raise their SOD contents, and has good effects of resisting ischemia and myocardial ischemia.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound capable of resisting cerebral ischemia and myocardial ischemia and improving memory function and its preparation method and application. Background technique [0002] There are many existing anti-ischemic drugs, such as thrombolysis, antithrombotic, and exogenous neurotrophic factors. Although some successful progress has been made in the treatment, most drug treatments still have many defects, such as: The molecular weight of the drug is large, and it is difficult to play a role through the blood-brain barrier; some drugs are prone to side effects such as bleeding; some treatment methods are difficult to operate, and the curative effect is not satisfactory. In addition, there is a lack of very effective anti-myocardial ischemia and memory-improving drugs. The present invention aims to find an effective drug with strong anti-cerebral ischemia and myocardial ischemia, simple us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/77A61K31/365A61K36/28A61P9/12A61K125/00
Inventor 闫福林詹合琴
Owner 闫福林
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