Anti-cancer slow release injection comprising plant alkaloid

Abstract

Disclosed is an anticancer slow release injection containing plant alkaloids, wherein the constituents include anti-cancer drugs, slow release auxiliary materials, suspending agent and / or dissolvent. The anti-cancer drugs include leurocristine, Vinblastine, procarbazine, leurosidine or vinorelbine, the slow release auxiliary materials can be selected from polylactic acid, glycolic acid and glycolic acid copolymer, ethylene-vinylacetate copolymer or their combination. The suspending agent is selected from sodium carboxymethylcellulose and mannitol. The dissolvent is selected from distilled water, water for injection, physiological lotion, absolute ethyl alcohol, microcosmic salt or carbonates cushioning liquid. The anticancer slow release injection can be administered through subcutaneous, intracavity, intra-tumor, tumor-surrounding, intra- lymph gland or bone marrow channels, the whole body toxicity reaction of the anti-cancer medicament can be lowered, the tumor local medicinal concentration can also be selectively increased and maintained, and the treatment effect of the non-operative treatment methods such as chemotherapy, medicament and radiation can also be improved.

Description

(1) Technical field [0001] The invention relates to an anticancer sustained-release injection containing plant alkaloids, which belongs to the technical field of medicines. (2) Background technology [0002] Plant alkaloid anticancer drugs, as commonly used chemotherapy drugs, have been widely used in the treatment of various malignant tumors, and have achieved relatively obvious effects. However, further studies have found that inappropriate drug administration often leads to the generation of tolerance, which eventually leads to the failure of treatment. Due to the excessive expansion and hyperplasia of solid tumors, the interstitial pressure, tissue elastic pressure, fluid pressure and interstitial viscosity are all higher than those of the surrounding normal tissues. Therefore, it is difficult for conventional chemotherapy to form an effective drug concentration in the tumor. See Kong Qingzhong "Intratumoral placement of cisplatin plus systemic carmustine in the treatme...

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Problems solved by technology

However, further studies have found that inappropriate drug administration often leads to the development of tolerance, which eventually leads to the failure of treatment

Due to the excessive expansion and hyperplasia of solid tumors, the interstitial pressure, tissue elastic pressure, fluid pressure and interstitial viscosity are all higher than those of the surrounding normal tissues. Therefore, it is difficult for conventional chemotherapy to form an effective drug concentration in the tumor. See Kong Qingzhong "Intratumoral placement of cisplatin plus systemic carmustine in the treatment of brain tumors in rats", "Journal of Surgical Oncology", 1998, 69, pages 76-82 (Kong Q et al., J Surg Oncol.1998 Oct; 69 (2) :76-82), simply increasing the dosage is limited by systemic reactions

Drug implantation may solve the problem of drug concentration to some extent. However, the operation of drug implantation is more complicated and traumatic. In addition to easily causing various complications such as bleeding, infection, and decreased immunity, it can also cause or accelerate tumor spread and metastasis