Cell growth-inhibiting film, medical instrument and stent for digestive organs

A technology for cell proliferation and medical equipment, applied in the field of cell proliferation inhibitory membranes, can solve problems such as hindering the flow of digestive juices, and achieve the effect of avoiding side effects and inhibiting cell proliferation

Inactive Publication Date: 2007-01-31
ZEON MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, since the membrane used in this coated stent cannot permeate digestive juice such as pancreatic juice, the flow of digestive juice is hindered by the coated stent, and serious symptoms such as pancreatitis caused by this may occur. become a problem

Method used

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  • Cell growth-inhibiting film, medical instrument and stent for digestive organs
  • Cell growth-inhibiting film, medical instrument and stent for digestive organs

Examples

Experimental program
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preparation example Construction

[0053] There are no particular limitations on the method for preparing the cell growth-inhibiting film of the present invention, and examples include casting an organic solvent solution of a resin onto a substrate, and while evaporating the organic solvent, a A method of generating condensation and evaporating tiny water droplets generated by the condensation.

[0054] More specifically, (1) cast the organic solvent solution of the resin onto the substrate, and slowly evaporate the organic solvent by blowing high-humidity air, and at the same time generate condensation on the surface of the casting liquid, and the evaporation is caused by the The method of tiny water droplets produced by dew; or (2) cast the organic solvent solution of the resin on the substrate under the atmosphere with a relative humidity of 50-90%, and while the organic solvent is evaporated, the liquid on the surface of the casting liquid A method of generating condensation and evaporating tiny water dropl...

Embodiment 1

[0120] Polyε-caprolactone (viscosity average molecular weight: 70000, manufactured by Wako Pure Chemical Industries, Ltd.) and Cap resin (weight average molecular weight: 62000, number average molecular weight: 21000) were dissolved in chloroform at a weight ratio of 10:1, and 6 ml of the obtained solution (resin concentration: 0.27% by weight) was similarly spread on a glass dish with a diameter of 10 cm.

[0121] Next, under an atmosphere of 23.0° C. and a relative humidity of 40%, blow high-humidity air with a relative humidity of 70% to the liquid surface on the glass dish at a flow rate of 2 L / min for 1 minute, thereby obtaining a film thickness of 1 to 30%. Membrane A of 2 μm. When the membrane A was observed at a magnification of 100 times using an optical microscope (BH2, manufactured by Olympus Corporation), it was confirmed that a honeycomb porous structure was formed. The average pore diameter of the pores constituting this porous structure was 3.5 μm, and the vari...

Embodiment 2

[0123] Except that Example 2 was performed under an atmosphere of 24.0° C. and Example 3 was performed under an atmosphere of 25.0° C., membranes B and C having a porous structure of a honeycomb structure were obtained in the same manner as in Example 1.

[0124] Table 1 shows the film thicknesses of the obtained films B and C, the average pore diameters of the pores constituting the porous structure, and the variation coefficient of the pore diameters.

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Abstract

The present invention provides a cell proliferation-suppressing membrane comprising a resin and having a porous structure formed at least on the surface of the membrane; and a method of inhibiting cell proliferation, wherein the method suppresses the proliferation of cells in the contact area by bringing cells into contact with the surface of the membrane , wherein the film contains a resin and forms a porous structure at least in the surface portion; a medical device, the medical device is formed by covering all or a part of the surface of a medical device base material with a film, wherein the film contains a resin, and at least A porous structure is formed on the surface; a digestive system stent, which is formed by coating a stent base material with a resin-containing film that forms a porous structure through through holes, wherein the average pore diameter of the through holes is 0.1 to 20 μm , The coefficient of variation of the pore diameter is 30% or less. According to the present invention, it is possible to provide a suitable material for constituting a medical device that exhibits the effect of inhibiting cell proliferation without using a physiologically active substance, and to secure a lumen in the body of the digestive system and allow digestive juice and digestive enzymes contained therein to pass through. A scaffold for the digestive system that does not allow cancer cells to penetrate.

Description

technical field [0001] The present invention relates to a cell proliferation inhibiting membrane, a method for inhibiting cell proliferation using the cell proliferation inhibiting membrane, a medical appliance, and a digestive system bracket placed in the lumen of digestive system such as bile duct, duodenum, and large intestine. Background technique [0002] It is known that in the interaction between cells and materials, cells are affected not only by the chemical properties of the material surface but also by the fine shape. For example, JP-A-2002-335949 describes a honeycomb structure film or a stretched film thereof. The honeycomb structure film is obtained by combining a biodegradable and hydrophilic-lipophilic polymer, Or a hydrophobic organic solvent solution of a polymer mixture comprising a biodegradable polymer and a hydrophilic-lipophilic polymer is cast onto a substrate, and while the organic solvent is evaporated, the organic solvent solution (casting liquid) ...

Claims

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Application Information

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IPC IPC(8): A61L31/00A61L27/00A61L29/00A61M29/02C12N5/07C12N5/071
Inventor 田中贤下村正嗣丰川秀英
Owner ZEON MEDICAL
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