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Heat-resisting protective immunopotentiator of freezing-dry activated vaccine for animal and its preparation

An immunopotentiator, a technology for animals, applied in freeze-dried delivery, medical preparations with non-active ingredients, pharmaceutical formulas, etc., can solve the problems of preservation, transportation, use of veterinary biological products, energy consumption and storage costs increase, etc. problems, to achieve the effect of improving the immune level, promoting antigen promotion, and improving humoral immunity

Inactive Publication Date: 2007-01-17
RINGPU (BAODING) BIOLOGICAL PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This brings many difficulties and inconveniences to the storage, transportation, and use of veterinary biological products. At the same time, strict low-temperature storage also causes energy consumption and storage costs to increase.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: get following material by weight percentage: gelatin 1.5%, Vc 0.3%, lactose 5%, beef peptone 1.5%, PVP (K30) 5%, sorbitol 2%, sodium glutamate 2%, bovine serum white Protein 2%, EDTA 1%, compound cytopeptide 2%, and the balance is distilled water.

Embodiment 2

[0023] Embodiment 2: get following material by weight percentage: gelatin 3%, Vc 0.2%, lactose 6%, beef peptone 2%, PVP (K30) 5%, sorbitol 1%, sodium glutamate 3%, bovine serum white Protein 1%, EDTA 2%, compound cytopeptide 2%, and the balance is distilled water.

Embodiment 3

[0024] Embodiment 3: get following material by weight percentage: gelatin 2%, Vc 0.1%, lactose 5.5%, beef peptone 1%, PVP (K30) 5%, sorbitol 3%, sodium glutamate 1%, bovine serum white Protein 1.5%, EDTA 3%, compound cytopeptide 2%, and distilled water as the rest.

[0025] The component materials in each embodiment are sterilized respectively: (1) to autoclavable material components such as gelatin, lactose, beef peptone, EDTA, PVP (K30), be dissolved in 1 / 2 distilled water total Sterilize at 120-125°C for 15 minutes; (2) Dissolve the non-autoclavable material components Vc, sorbitol, sodium glutamate, bovine serum albumin, and compound cytopeptide in the remaining 1 / 2 2. In distilled water, use a filter membrane with a pore size of 0.22 μm to filter and sterilize; after the sterilization is completed, mix the two solutions to obtain the heat-resistant protective immune enhancer.

[0026] When used, it is added to the virus antigen solution at a ratio of 1:1, and then freeze...

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Abstract

A refractory immunopotentiator for the freeze-dried living vaccine of animal in order to elongate its storage period to more than 24 months at 2-8 deg.C and improve its immunizing level and power is proportionally prepared from gelatin, VC, lactose, beef peptone, PVP, sorbitol, sodium glutamate, bovine serum albumin, EDTA, compound cell peptide and distilled water through high-pressure removal of bacteria, filtering and proportional mixing.

Description

technical field [0001] The invention relates to an improved protective agent for making freeze-dried live vaccines for animals, which belongs to the technical field of medical products. Background technique [0002] Freeze-dried live vaccines for animals are a powerful weapon to control animal virus or bacterial infection. Storing freeze-dried live vaccines at room temperature can not only greatly reduce production costs, but also provide convenience for the transportation, storage and use of such products. In addition, it It can also reduce the on-site application loss rate of the vaccine, thereby increasing the effective immune protection rate of the vaccine unit. Freeze-dried live vaccines often cause a large amount of vaccine inactivation during the production process, so it is necessary to add protective agents for protection. At present, the main components of commonly used protective agents for veterinary biological products are skim milk, sucrose and gelatin, which ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K9/19A61K47/34A61K47/26A61K47/10A61K47/32
Inventor 杨保收张俊平厉从志刘健王永建
Owner RINGPU (BAODING) BIOLOGICAL PHARMACEUTICAL CO LTD
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