Medicinal composition containing calcium agonist and phenoxy acid compound

A technology of calcium antagonists and phenoxy acids, which is applied in the field of pharmacy, can solve the lack of prevention or treatment of hypertension combined with hyperlipidemia, and achieve the effects of delaying cardiovascular and cerebrovascular diseases, taking medicine conveniently, preventing or delaying damage

Active Publication Date: 2010-04-21
SHENZHEN AUSA PHARM CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the clinical problem of lack of effective drugs for the prevention or treatment of hypertension combined with hyperlipidemia, the purpose of the present invention is to provide a pharmaceutical composition for the preparation of drugs for the prevention or treatment of hypertension combined with hyperlipidemia

Method used

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  • Medicinal composition containing calcium agonist and phenoxy acid compound
  • Medicinal composition containing calcium agonist and phenoxy acid compound
  • Medicinal composition containing calcium agonist and phenoxy acid compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. Effects of a pharmaceutical composition containing amlodipine and fenofibrate on blood pressure and blood lipids in hypertensive rats with hyperlipidemia

[0032] The left renal artery of SD rats was narrowed with a 0.2 mm silver clip, and the blood pressure of the rats increased by more than 150 mmHg after 8 to 10 weeks, and they were considered hypertensive animals. Another 20 normal rats were used as the normal control group. Feed high-fat feed to hypertensive rats (the formula is: cholesterol 1%, propylthiouracil 0.2%, sodium cholate 0.3%, lard 10%, basal feed 88.5%), normal control group rats are fed with common feed. After 4 weeks, blood pressure (systolic blood pressure SBP, diastolic blood pressure DBP) of the rats was measured, and blood samples were collected to measure serum cholesterol (CHO), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and Low-density lipoprotein (VLDL). According to blood pressure and blood...

Embodiment 2

[0043] Example 2. Effect of a pharmaceutical composition containing nitrendipine and ciprofibrate on hypertensive rats with hyperlipidemia

[0044] The left renal artery of SD rats was narrowed with a 0.2 mm silver clip, and the blood pressure of the rats increased by more than 150 mmHg after 8 to 10 weeks, and they were considered hypertensive animals. Another 20 normal rats were used as the normal control group. Feed high-fat feed to hypertensive rats (the formula is: cholesterol 1%, propylthiouracil 0.2%, sodium cholate 0.3%, lard 10%, basal feed 88.5%), normal control group rats are fed with common feed. After 4 weeks, the blood pressure (SBP, DBP) of the rats was measured, and blood was collected to measure serum CHO, TG, HDL, LDL, and VLDL. According to blood pressure and blood lipid levels (mainly DBP, TG, VLDL), hypertensive rats with hyperlipidemia were divided into model group, nitrendipine group (1.0 mg / kg), ciprofibrate group (2.0 mg / kg), Nitrendipine+ciprofibrat...

Embodiment 3

[0058] Example 3. Effects of a pharmaceutical composition containing felodipine and benzclofibrate on blood pressure and blood lipids in hypertensive rats with hyperlipidemia

[0059] The left renal artery of SD rats was narrowed with a 0.2mm silver clip, and the blood pressure of the rats increased by more than 140mmHg after 8 to 10 weeks, and they were considered hypertensive animals. Another 20 normal rats were used as the normal control group. Feed high-fat feed to hypertensive rats (the formula is: cholesterol 1%, propylthiouracil 0.2%, sodium cholate 0.3%, lard 10%, basal feed 88.5%), normal control group rats are fed with common feed. After 4 weeks, the blood pressure (SBP, DBP) of the rats was measured, and blood was collected to measure serum CHO, TG, HDL, LDL, and VLDL. According to blood pressure and blood lipid levels (mainly DBP, TG, VLDL), hypertensive rats were divided into model group, felodipine group (1.0mg / kg), benzclofibrate group (10mg / kg), felodipine+ B...

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Abstract

The present invention discloses an application of medicine composition containing medicinal dose calcium antagonist, medicinal dose phenoxy acid medicine and pharmaceutically-acceptable carrier in thepreparation of medicine with synergistic action of reducing blood pressure or / and synergistic action of reducing blood lipid or / and synergistic action of changing vascular compliance or / and synergistic action of delaying targent organ damage. Said invention also relates to the application of said medicine composition in preparation of medicine for preventing, curing and delaying angiocardiopathyand cerebrovascular diseases.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing a calcium antagonist and a phenoxy acid compound used in the preparation of drugs for lowering blood pressure, or / and lowering blood lipids, or / and changing the compliance of blood vessels, or / and delaying target organ damage in the application. The present invention belongs to the field of pharmacy. Background technique [0002] Cardiovascular disease is a common disease and accounts for the first cause of human death; epidemiological studies have found that most patients have high blood pressure and high blood lipids at the same time, and their risk of cardiovascular disease is very high. It is estimated that 30 million American patients have been diagnosed with these two high-risk factors; in China, a cross-sectional survey of 711 hypertensive patients with hyperlipidemia found that 186 hypertensive patients with hyperlipidemia, the disease The rate is 26.2%, which is signifi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/4422A61K9/16A61K9/20A61K9/48A61P9/12A61P9/10A61P3/06
Inventor 陈光亮王琳琳段炎炎李莉
Owner SHENZHEN AUSA PHARM CO LTD
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