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Antivirus effective position of isatis root

An effective part and anti-virus technology, which is applied in the direction of anti-viral agents, medical preparations containing active ingredients, and medical raw materials derived from angiosperms, can solve the problem of low purity, low content of active ingredients, and restrictions on Banlangen injection. Clinical application and other issues, to achieve good therapeutic effect, fast onset, and definite antiviral effect

Inactive Publication Date: 2007-01-10
深圳市天一誉医药投资咨询有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Isatis root injection is used to treat mumps, keratitis and other viral diseases, and has achieved good therapeutic effect in clinical practice. However, the current Isatis root injection can only be used for intramuscular injection and Acupoint injection greatly limits the clinical application of Banlangen injection
At present, there is no isatis root intravenous injection with high active ingredient content, stable quality, and high bioavailability for intravenous injection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1: injection

[0049] Take 1000g of Radix isatidis, add 6 times the amount of 65% ethanol to reflux and extract twice, each time for 2 hours, filter, add 5 times the amount of water to decoct the medicinal residues for 1 hour, filter, combine the filtrates, recover the ethanol to about 1000ml, filter, Add ethanol to the filtrate to make the alcohol content to 65%, refrigerate for 24 hours and filter, adjust the pH value of the filtrate to 8.5 with ammonia test solution, refrigerate and filter; recover the ethanol from the filtrate until it has no alcohol smell, concentrate to about 1000ml, and pass through D-101 macropore adsorption Resin, wash about 2 times the volume of the resin bed until there is no ninhydrin reaction, collect the effluent and washing liquid, pass through a polyethersulfone membrane, and collect the effluent with a molecular weight of 100-10000; then wash 5 to 6 resin beds with 70% ethanol Volume until colorless or very light in color, co...

Embodiment 2

[0050] Embodiment 2: large volume injection

[0051] Take 1000g of Radix isatidis, add 6 times the amount of 65% ethanol to reflux and extract twice, each time for 2 hours, filter, add 5 times the amount of water to decoct the medicinal residues for 1 hour, filter, combine the filtrates, recover the ethanol to about 1000ml, filter, Add ethanol to the filtrate to make the alcohol content to 65%, refrigerate for 24 hours and filter, adjust the pH value of the filtrate to 8.5 with ammonia test solution, refrigerate and filter; recover the ethanol from the filtrate until it has no alcohol smell, concentrate to about 1000ml, and pass through D-101 macropore adsorption Resin, wash about 2 times the volume of the resin bed until there is no ninhydrin reaction, collect the effluent and washing liquid, pass through a polyethersulfone membrane, and collect the effluent with a molecular weight of 100-10000; then wash 5 to 6 resin beds with 70% ethanol Volume until colorless or very light...

Embodiment 3

[0052] Embodiment 3: Freeze-dried powder for injection

[0053] Take 1000g of Radix isatidis, add 6 times the amount of 65% ethanol to reflux and extract twice, each time for 2 hours, filter, add 5 times the amount of water to decoct the medicinal residues for 1 hour, filter, combine the filtrates, recover the ethanol to about 1000ml, filter, Add ethanol to the filtrate to make the alcohol content to 65%, refrigerate for 24 hours and filter, adjust the pH value of the filtrate to 8.5 with ammonia test solution, refrigerate and filter; recover the ethanol from the filtrate until it has no alcohol smell, concentrate to about 1000ml, and pass through D-101 macropore adsorption Resin, wash about 2 times the volume of the resin bed until there is no ninhydrin reaction, collect the effluent and washing liquid, pass through a polyethersulfone membrane, and collect the effluent with a molecular weight of 100-10000; then wash 5 to 6 resin beds with 70% ethanol Volume until colorless or...

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PUM

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Abstract

The present invention relates to an antiviral effective component of Chinese medicinal material isatis root. Said invention also relates to a medicine preparation containing said antiviral effective component of isatis root and its preparation method. It is mainly characterized by that its preparation process mainly adopts the combination of macroporous adsorbing resin and decoloring resin to make purification, and adopts membrane filtration technique to maximally retain effective component and remove related impurity component, so that said medicine preparation can obtain good therapeutic effect for curing the diseases of influenza, virus hepatitis, upper respiratory tract infection, parotitis, keratitis and other viral diseases.

Description

technical field [0001] The invention relates to an antiviral effective part of Radix isatidis and a preparation method thereof. The invention also relates to a pharmaceutical preparation containing the antiviral effective part of Radix isatidis and a preparation method thereof. Background technique [0002] Radix isatidis, also known as indigo root, blue indigo root, indigo root, is the dried root of Isatis indigotica Fort, a cruciferous plant. It is recorded in the first volume of "Chinese Pharmacopoeia" as a commonly used traditional Chinese medicine. It is bitter in taste and cold in nature, enters the heart and stomach meridians, and has the effects of clearing heat and detoxifying, cooling blood and reducing swelling. Clinically, it is mostly used in the treatment of Japanese encephalitis, influenza, mumps, acute hepatitis in children, herpes simplex virus keratitis, pharyngitis, flat warts, pink eye disease, dacryocystitis, chickenpox, etc. It is one of the few tradi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/315A61K36/19A61K9/08A61K9/19A61P31/12
Inventor 刘玉辉唐星
Owner 深圳市天一誉医药投资咨询有限公司
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