Microflow chip and method for preparing polymer microsphere using same

Abstract

The invention relates to a microflow chip comprising synthesized channel and two beam focusing ball tracks, in which two exits of beam focusing ball tracks converge at the entrance of the synthesized channel, each beam focusing ball track comprises prepolymer microsphere track, discontinuous phase track and two continuous phase channels, the said two continuous phase channels distribute on both sides of the discontinuous phase track, the prepolymer microsphere track, discontinuous phase track and continuous phase channels evenly have ingate and exit and the exits of the discontinuous phase track and continuous phase channels converge at the ingate of the synthesized channel. The invention also provides a method for preparing polymer microsphere using the said microflow chip: injecting two continuous phases from ingates of continuous phase channels of two beam focusing channels, injecting discontinuous phase from discontinuous phase channels of beam focusing channels, then obtaining polymer microsphere from the synthesized channel exit. The invention can exactly prepare controllable polymer microsphere with coincidence sizes.

Description

technical field [0001] The invention relates to a microfluidic chip and a method for preparing polymer microspheres by using the microfluidic chip, in particular to a micromachining design structure, which requires the design to conform to the principle of fluid dynamics, and belongs to the field of microfluidic chips. It can be applied to chemical synthesis to obtain polymer microspheres, which belongs to the field of chemical synthesis. Cells can also be added into biocompatible polymer microspheres to solidify into balls, which can be used as a favorable environment for cell culture, transfer, storage and analysis, and belong to the field of biological cytology. It can also be used in the field of drug sustained release to wrap drugs, and belongs to the field of biopharmaceuticals. Background technique [0002] Controllable polymer microspheres with a diameter of 10-100 μm have attractive potentials in biological, chemical, and medical applications. The traditional prep...

AI Technical Summary

Problems solved by technology

Preparation of polymeric microspheres by traditional methods either cannot precisely control the diameter, or the microspheres have a large size distribution, or require a large amount of reagents

Moreover, these traditional preparation methods make it difficult to keep the organism from being damaged when coating the organism

The diameter of monodisperse polymer microspheres currently prepared is generally distributed above 100 microns or below 10 microns, and it is difficult to prepare by traditional means between 10-100 microns

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