Hydantion method compolete preparation of chromium selenomethionine compounds (III) and its uses

Abstract

The invention relates to a integrated method for preparing seleno chromium methionine (III) through hrdantoin and its application. The intermediate seleno acimetion with multiple biological activity and usage can be prepared with said method. The Cr3+ in chromium trichloride hexahydrate can produce three modifications of different construction with one to three acid molecules, which are named as I-seleno chromium methionine, II-seleno chromium methionine and seleno chromium methionine (containing three acid molecules). The difference in performance and effect of three modifications is favorable for controlling content and proportion of selenium and chromium in compound. The compound can be widely used in medicine, health care product, feed addictive and cosmetics, especially used to produce capsule, tablet and oral liquid prevent and treating diabetes.

Description

1. Technical field [0001] 1.1 The present invention relates to a chromium (III) compound of selenomethionine for preventing and treating diabetes with insulin-mimetic effect. [0002] 1.2 The present invention relates to the technical route and process flow of the Hein process used in the world to produce methionine. It is improved and innovated and developed into a one-stop method from the preparation of selenomethionine, a selenoanalog of methionine, to the preparation of chromium selenomethionine ( III) New methods of compounds. [0003] 1.3 The present invention relates to the improvement, supplement and development of the "Preparation and Application of Chromium Selenomethionine" (application number 98120472.4) previously applied by the inventor, especially the integration of existing technologies into a one-stop preparation method to realize the Trivalent chromium (III), selenomethionine selenomethionine analogue of methionine is prepared into selenomethionine chromium ...

AI Technical Summary

Problems solved by technology

Since selenomethionine has not been produced on a large scale in the world until today, and it is only sold exclusively by Sigma-Aldrich, and the price is as high as $86 per gram, therefore, the inventor’s previous application failed to go out of the laboratory to form a product, and in addition The technology is immature and failed to pass the substantive examination

[0006] 2.2 Defects of the prior art: While reflecting on the invention of the chromium selenomethionine substance proposed before 1998, the inventors followed up and observed the preparation technology of selenomethionine in recent years, and realized that the prior art had the following defects:

[0007] 2.2.1 The preparation method is cumbersome: according to past experience and the retrieval and verification of existing literature, it is necessary to prepare methionine first, use methionine as the starting material to prepare selenomethionine, and then use selenomethionine as the starting material and trivalent chromium (III) Synthesis of target selenomethionine chromium (III) compound

[0008] 2.2.2 Large-scale production of selenomethionine has not yet been realized: as we all know, although there are many studies on the biochemistry, physiological functions and pharmacological activities of selenomethionine, there is no large-scale industrial production of selenomethionine in the world. , and there is no suitable selenomethionine commodity supply market, and the only supplier is still Sigma-Aldrich in the United States, which affects the application and development of selenomethionine

[0009] 2.2.3 Constraints on production costs: Since the research on the synthesis of selenomethionine at home and abroad is still in the laboratory stage, many experimental studies tend to use methionine as the starting material, and introduce methyl selenium into methionine to replace methyl Sulfur-based method [Wang Jiang, et al., Synthesis of selenomethionine, Chemical Engineers, 1997, 1(58): 49-50]; γ-bromobutyl is also used as raw materials to prepare lithium methyl selenide and methionine abroad. Selenomethionine is produced by acid reaction (Transition Met.Chem.1997, 22:492-496). The synthetic raw material needs 2 tons of methionine to synthesize 1 ton of selenomethionine. If L-methionine is used (350,000 yuan per ton in China) Production costs are staggeringly higher

Therefore, backward technology restricts cost

[0010] 2.2.4 The inventor’s previous application was not only limited by cost, but more importantly, it did not clearly describe the structural formula of the chromium selenomethionine compound, and did not provide important physical and chemical parameters; there was no clearly characterized technical subject, and the claims did not Supports the protection of deficiencies such as chromium selenomethionine

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