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An anti-tumor pharmaceutical composition and preparation method thereof

A composition and anti-tumor technology, applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as side effects and changes

Active Publication Date: 2006-12-20
李东轩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These three treatment approaches are effective in the treatment of tumors, but radiotherapy and chemotherapy mainly focus on the killing effect on tumor cells, and also kill normal cells. The toxicity to tissue cells that proliferate rapidly such as hematopoiesis is particularly common, and has a greater impact. Toxic and side effects such as: bone marrow suppression, changes in peripheral blood, immunosuppression, nausea and vomiting, fatigue, hair loss, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1: Preparation of freeze-dried powder injection

[0059] Ginseng 100kg, Astragalus 300kg, Oxymatrine 10kg

[0060] Put 100kg of raw material medicine ginseng into a counter-current circulation ultrasonic extraction tank, add 8 times the weight of 75% ethanol, firstly warm for 12 hours, at room temperature, stirring speed 200r / min, counter-current circulation ultrasonic extraction for 1 hour, the extract is filtered, Ethanol recovers the ginseng clear ointment with a relative density of 1.10-1.15 at 60℃ and concentrated under reduced pressure;

[0061] Put 300kg of raw material medicine Astragalus into a countercurrent circulation ultrasonic extraction tank, add 6 times the amount of purified water to warm soak for 2 hours, at room temperature, stirring speed 200r / min, countercurrent circulation ultrasonic extraction for 1 hour, the extract is carried out with a three-effect concentrator Concentration, control the temperature of the first-effect concentrator 70-80℃, ...

Embodiment 2

[0068] Example 2: Preparation of injection water for injection

[0069] Ginseng 100kg, Astragalus 300kg, Oxymatrine 10kg

[0070] Put 100kg of the raw material drug ginseng into a countercurrent circulation ultrasonic extraction tank, add 10 times the weight of 85% ethanol, first warm soak for 18 hours, at room temperature, stirring speed 280r / min, countercurrent circulation ultrasonic extraction for 1.5 hours, and then reflux extraction for 3 hours. For the second time, add 6 times by weight of 75% ethanol for reflux extraction for 2 hours, and for the third time, add 6 times by weight of 75% ethanol for reflux extraction for 2 hours. The combined extracts are filtered, recovered with ethanol and concentrated under reduced pressure to 60°C relative density 1.10- 1.15 ginseng clear ointment;

[0071] Put 300kg of raw material medicine Astragalus into a countercurrent circulation ultrasonic extraction tank, add 8 times the amount of purified water to warm soak for 2.5 hours, at roo...

Embodiment 3

[0078] Example 3: Preparation of capsules

[0079] Ginseng 100kg, Astragalus 300kg, Oxymatrine 10kg

[0080] Put 100kg of raw material medicine ginseng into a countercurrent circulation ultrasonic extraction tank, add 6 times weight of 65% ethanol, first warm soak for 8 hours, at room temperature, stirring speed 150r / min, countercurrent circulation ultrasonic extraction for 0.5 hours, the extract is filtered and used Ethanol recovers the ginseng clear ointment with a relative density of 1.10-1.15 at 60℃ and concentrated under reduced pressure;

[0081] Put 300kg of the raw material medicine Astragalus into a countercurrent circulation ultrasonic extraction tank, add 4 times the amount of purified water for the first time, and then warm it for 1.5 hours, at room temperature, stirring speed 150r / min, countercurrent circulation ultrasonic extraction for 0.5 hours, and the extract has three effects Concentrator for concentration, control the temperature of the first-effect concentrato...

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Abstract

The invention relates to a medicinal composition and method for preparation, wherein the medicinal composition is prepared from astragalus root, gen-seng, flavescent sophora root through supersonic extracting, alcohol depositing, water depositing, formulating, loading and freeze-drying. The composition can be used for treating primary liver cancer, lung carcinoma, esophagus cancer, restocarcinoma, malignant lymphoma, gynaecologic carcinoma, leucopenia and chronic hepatitis B.

Description

Technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to an anti-tumor pharmaceutical composition and a preparation method thereof. Background technique [0002] Chinese medicine believes that the human body is an organic whole. When the body is under the influence of certain internal and external factors, causing a certain link of balance imbalance, it will lead to systemic pathological and physiological changes, and systemic pathological changes can be manifested locally. , Malignant tumors are the local manifestations of systemic diseases. Deficiency of positive qi is a key factor in both internal and external causes of tumors. [0003] The traditional treatment methods for malignant tumors are mainly: chemotherapy, radiotherapy, and surgery. These three treatment approaches are effective for the treatment of tumors, but radiotherapy and chemotherapy mainly focus on the killing effect on tumor cells and als...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/08A61K9/19A61P35/00A61P1/16A61P31/20A61K31/4375
Inventor 李世红
Owner 李东轩
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