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Externally applied liquid asiaticoside preparation and its preparing process

A technology of liquid preparation and asiaticoside, which is applied in the preparation of sterile external medicines for promoting the healing of various wounds, the field of liquid preparations for external use of asiaticoside and its preparation, which can solve the problems such as easy contamination of the wound surface and inability to meet the requirements of sterility. , to achieve the effect of not easily wound surface pollution, avoiding infection and causing wound surface pollution

Inactive Publication Date: 2006-11-08
浙江茵诺邦健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the preparations used for human wounds are required to be aseptic and not pollute the wounds. At present, the ointment in asiaticoside preparations cannot meet the sterile requirements according to the current production conditions, and their matrix is ​​easy to cause pollution to the wounds.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 A kind of asiaticoside solution for external use

[0015] ① Preparation composition (dosage per 100ml)

[0016] Asiaticoside 0.1g (0.1%)

[0017] Water for injection 99.9g (99.9%)

[0018] ②Preparation method: Take about 80g of water for injection, add 0.1g of asiaticoside, heat to 60°C and stir to make it completely dissolved, filter until clear, cool to room temperature, add water for injection to the full amount, adjust the pH of the liquid to 6.0, and stir well Afterwards, semi-finished products are tested, and the content is determined to be 96%-104% (HPLC). Then heat up to about 60°C, add activated carbon with a volume of 0.1% (w / v) of the liquid medicine, keep warm for 20 minutes, and cool naturally to room temperature. Use a G4 glass filter element for coarse filtration, control the pH value of the liquid to 4.5-5.0 after decarburization, and then pass through a 0.2 μm filter element for fine filtration, check the properties and clarity of the liqui...

Embodiment 2

[0019] Example 2 The second embodiment of asiaticoside solution for external use

[0020] ① Preparation composition (dosage per 100ml)

[0021] Asiaticoside 2g (2.0%)

[0022] Medicinal ethanol 10g (10.0%)

[0023] Sterile water 88g (88.0%)

[0024] ② Preparation method: Mix medicinal ethanol and sterile water evenly to form a medicinal solvent, take about 80% of the above medicinal solvent, add the prescribed amount of asiaticoside, heat to 70°C and stir to make it completely dissolved, filter until clear, and cool to At room temperature, add medicinal solvent to the full amount, adjust the pH value of the medicinal solution to 6.5, stir well and then carry out semi-finished product testing. Then heat up to about 60°C, add activated carbon with a volume of 0.5% (w / v) of the liquid medicine, keep warm for 20 minutes, and cool down to room temperature naturally. Use a G4 glass filter element for coarse filtration, and then pass through a 0.2μm filter element for fine filtra...

Embodiment 3

[0025] Example 3 The third embodiment of asiaticoside liquid for external use

[0026] ① Preparation composition (dosage per 100ml)

[0027] Asiaticoside 30g (30%)

[0028] Propylene glycol 25g (25%)

[0029] 45g (45%) sterile water

[0030] ②Preparation method: Dissolve 30g asiaticoside in the mixed solvent,

[0031] Mix propylene glycol and sterile water into a medicinal solvent, take about 80% of the above medicinal solvent, add the prescribed amount of asiaticoside, heat to 80°C and stir to dissolve it completely, filter until clear, cool to room temperature, and add medicinal solvent To the full amount, adjust the pH value of the liquid to 6.5, stir well and then carry out semi-finished product testing. Then heat up to about 60°C, add activated carbon with a volume of 0.5% (w / v) of the liquid medicine, keep warm for 20 minutes, and cool down to room temperature naturally. Filling, Co-60 irradiation sterilization, that is.

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PUM

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Abstract

The externally applied liquid asiaticoside preparation has effective component comprising asiaticoside 0.1-30.0 wt% and medicinal solvent 70.0-99.9 wt%. Its preparation process includes dissolving asiaticoside in the medicinal solvent, filtering, filling, sterilizing and packing. The present invention expands the clinical application of asiaticoside, and the abacterial preparation has high medicine concentration, high medicinal effect, no wound infection, and other advantages.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a liquid preparation for external use of asiaticoside and a preparation method thereof, which are suitable for preparing sterile external use drugs for promoting various wound healing. Background technique [0002] The asiaticoside preparation for external use is scientifically prepared from total saponins of asiatica. Centella asiatica is the whole plant of Centella asiataca, and its total saponins are a wound healing accelerator. A number of saponins have been isolated from it, and its main component is asiaticoside, or asiaticoside, which is composed of two molecules of glucose, one molecule of rhamnose and asiatic acid (or called asiatia acid). An ester glycoside formed by combining carboxyl groups in the molecule. Accompanying with asiaticoside is madecassoside, which is also an ester glycoside. The aglycone obtained after hydrolysis is madecassic acid, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P17/02
Inventor 胡钢亮郑伟平邵胜荣吕庆中
Owner 浙江茵诺邦健康科技有限公司
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