Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Lyophilized injection powder using Lanluodier and its salt as active ingredients and preparing technique therefor

A technology of freeze-dried powder injection and preparation process, which is applied in the field of medicine

Inactive Publication Date: 2006-09-06
BEIJING RUNDEKANG MEDICAL TECH CO LTD
View PDF0 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no related patent in China

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Lyophilized injection powder using Lanluodier and its salt as active ingredients and preparing technique therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Lamloridil hydrochloride freeze-dried powder for injection

[0022] prescription:

[0023] Component Dosage

[0024] Lamlordil Hydrochloride 50g

[0025] Mannitol 50g

[0026] 0.5% sodium bicarbonate solution appropriate amount

[0027] Add water for injection to 2000ml

[0028] A total of 1000 bottles were made

[0029] Preparation:

[0030] Weigh the prescribed amount of lanlopil hydrochloride and dissolve it with 80% water for injection to make a lanlopil hydrochloride solution, add the prescribed amount of mannitol, adjust the pH value to 3.0-6.0, heat the liquid to about 60°C, press Add 0.1% activated carbon for needles to the prepared amount, stir for 30 minutes, filter and decarbonize, and then use a 0.22 μm microporous membrane for fine filtration. After the intermediate is qualified, it is aseptically filled in a 5ml vial (theoretical volume of each bottle is 2ml) , put the medicinal solution in a freeze-drying box and freeze for 4 hours, so th...

Embodiment 2

[0031] Embodiment 2: Lanodil hydrochloride freeze-dried powder injection

[0032] prescription:

[0033] Component Dosage

[0034] Lamlordil Hydrochloride 25g

[0035] Dextran 50g

[0036] 1% sodium hydroxide solution appropriate amount

[0037] Add water for injection to 1000ml

[0038] A total of 1000 bottles were made

[0039] Preparation:

[0040] Weigh the prescribed amount of lanlordil hydrochloride and add it to 80% water for injection heated to about 60°C to dissolve, then add the prescribed amount of dextran to adjust the pH value to 3.0-6.0, add 0.1% activated carbon for needles according to the prepared amount, and keep stirring for 30 minutes , filtered, decarbonized, and finely filtered with a 0.22μ.m microporous membrane. After the intermediate is qualified, it is aseptically filled in a 2.7ml vial (theoretical amount of each bottle is 1ml), and the medicinal solution is placed in a freezer. Dry box, freeze for 3 hours, so that the temperature drops to abo...

Embodiment 3

[0041] Embodiment 3: Lanodil hydrochloride freeze-dried powder injection

[0042] prescription:

[0043] Component Dosage

[0044] Lamlordil Hydrochloride 50g

[0045] Glycine 25g

[0046] Sodium Metabisulfite 2g

[0047] Sodium Calcium EDTA 1g

[0048] 1% sodium hydroxide solution appropriate amount

[0049]Add water for injection to 2000ml

[0050] A total of 1000 bottles were made

[0051] Preparation:

[0052] Weigh the prescribed amount of lanolodil hydrochloride and add it to 80% water for injection heated to about 60°C to dissolve, then add the prescribed amount of glycine, sodium metabisulfite, sodium calcium edetate, stir to dissolve and adjust the pH value to 3.0-6.0 , add 0.1% activated carbon for needles according to the prepared amount, heat and stir for 30 minutes, filter, decarbonize, and then finely filter with a 0.22 μm microporous membrane. After the intermediate is qualified, it is aseptically filled in a 5ml vial (each bottle Theoretical amount is ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

This invention is about a freeze-dried preparation using Llandeilo and its salt as active components and its making method and usages. It is a medicine composition that takes Llandeilo and its salt as active components, and is formed by mixing acceptable finding. It can be used to emergency cure tachycardia arrhythmia (containing atria fibrillation, atria flutter and sinus tachycardia) during operation. It uses Llandeilo and its salt as raw materials, adds some findings of specify kinds and proportions, and develop freeze-dried preparation according to this invention for intravenous injection.

Description

technical field [0001] The invention relates to a freeze-dried powder injection with lanlordil and its salt as active ingredients and a preparation process thereof, belonging to the technical field of medicine. Background technique [0002] The chemical name of Landisolol hydrochloride is [0003] 4-[(2S)-2-Hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]benzenepropanoic acid[(4S)-2,2-dimethyl-1,3-dioxolan- 4-y1] methyl ester. [0004] Its chemical structure is [0005] [0006] Landisolol hydrochloride is a novel adrenergic beta 1 - Receptor antagonists whose anti-arrhythmic mechanism of action is mainly on cardiac beta 1 receptors, and inhibit the sympathetic nerve endings and norepinephrine released from the adrenal medulla and increase the number of heart beats caused by adrenaline, used for tachycardia arrhythmia (including atrial fibrillation, atrial flutter, emergency treatment of sinus tachycardia). [0007] In the experimental model of tachy...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5377A61K9/19A61P9/06A61P41/00
Inventor 路洪书
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products