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Method for raising utilizing degree to oral organism-absorbing of lumbrukinase

A lumbrokinase and lumbrokinase enteric technology, applied in the field of improving or improving the oral absorption bioavailability of lumbrokinase and enteric-coated combination preparations, can solve the problems of in-depth, unsystematic research work, etc., so as to improve the concentration of lumbrokinase and improve the treatment effect, effect of improving bioavailability

Inactive Publication Date: 2006-08-09
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, the research work on the oral absorption mechanism of peptides and proteins (such as insulin, insulin-like growth factor and epidermal growth factor) is still not systematic and in-depth

Method used

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  • Method for raising utilizing degree to oral organism-absorbing of lumbrukinase
  • Method for raising utilizing degree to oral organism-absorbing of lumbrukinase
  • Method for raising utilizing degree to oral organism-absorbing of lumbrukinase

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation process of lumbrokinase enteric-coated combination preparation

[0031] 4mg lumbrokinase, 20mg bacitracin, 4mg Na 2 - A 200mg lumbrokinase combination preparation that can be filled into enteric-coated capsules after mixing EDTA and 172mg dextran evenly.

Embodiment 2

[0032] Embodiment 2, lumbrokinase combined with absorption enhancer

[0033] Mix a certain proportion of absorption enhancers (sodium deoxycholate, Na2EDTA, chitosan, sodium lauryl sulfate, sodium octanoate, poloxamer, hydroxypropyl-β-cyclodextrin) with a certain concentration of FITC Fluorescently labeled lumbrokinase was mixed to make a solution. Use lumbrokinase alone as a control. The duodenal administration method was adopted. First, the abdominal cavity was opened by surgery, and a certain volume of drug solution was injected into the intestinal cavity at one time, and blood was collected from the orbit to measure the drug concentration in plasma at each time point.

Embodiment 3

[0034] Embodiment 3, lumbrokinase combined with enzyme inhibitor

[0035] Mix a certain proportion of enzyme inhibitors (bacitracin, casein, betatin, leupeptin, aprotinin, pancreatin inhibitor, sodium glycocholate) with a certain concentration of FITC fluorescently labeled lumbrokinase Prepared as a solution. Use lumbrokinase alone as a control. The duodenal administration method was adopted. First, the abdominal cavity was opened by surgery, and a certain volume of drug solution was injected into the intestinal cavity at one time, and blood was collected from the orbit to measure the drug concentration in plasma at each time point.

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Abstract

This invention belongs to pharmaceutical dosage form and preparation technique field, it relates to improve or advance the method of angleworm kinase oral administration absorbing being availability. Its features lie in that angleworm kinase concentration in vivo blood plasma can be effective improved or advanced when angleworm kinase is used with absorption enhancer or / and enzyme inhibitor, so angleworm kinase curative effect can be advanced. The features of this invention is that angleworm kinase is used with absorption enhancer or / and enzyme inhibitor to achieve the goal of improve angleworm kinase oral administration absorption capacity.

Description

Technical field: [0001] The invention belongs to the technical field of pharmaceutical dosage forms and preparations, and relates to a method for improving or increasing the bioavailability of oral absorption of lumbrokinase, that is, an enteric-coated combination prepared by mixing lumbrokinase with absorption promoters or / and enzyme inhibitors during oral administration The preparation can effectively improve or increase the concentration of lumbrokinase in plasma in the body, thereby improving the curative effect of lumbrokinase. Background technique: [0002] Thrombosis has always been an important disease that plagues human beings. It is the last key link leading to the development of heart, brain and peripheral blood vessels, and the direct cause of death and disability. We are facing the great challenge of thrombotic disease. Lumbrokinase (earthworm fibrinolytic enzyme, EFE) is an earthworm fibrinolytic enzyme extracted from an earthworm called "Earthworm". The zymo...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K38/57A61P7/02A61P9/10
Inventor 王坚成李玉华张强张华
Owner PEKING UNIV
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