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Orally quick-acting tablet of ginseng stem leaf saponin including orally disintegrating tablet and dispersible tablet and method for preparing the same

A technology for oral disintegration of ginseng stems and leaves and glycosides, which is applied in the field of medicine, can solve the problems of affecting drug absorption, dissolution rate reduction, and precipitation of drug crystals, etc., and achieves the effects of simple preparation process, convenient administration, and fast absorption

Active Publication Date: 2006-07-26
ANHUI PROV INST OF BIOLOGICAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the solid dispersion prepared by medicine and PEG is stored for a long time, there will be aging phenomena such as precipitation of medicine crystals and decrease in dissolution rate, which will affect the absorption of medicine. Due to the above obvious shortcomings in the existing oral dosage forms of total ginseng saponins, it is urgent to develop new ones. Oral preparations with better effects, rational development of ginseng, and improvement of the utilization rate of total ginsenosides

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Calculated by preparing 1000 tablets, the weight composition of raw materials is: 50g of total saponins from ginseng stems and leaves, 120g of lactose, 18g of low-substituted hydroxypropyl cellulose, 21g of cross-linked polyvinylpyrrolidone, 135g of microcrystalline cellulose, and 3g of magnesium stearate , made 1000 tablets in total, tablet specifications: each tablet contains 50 mg of total saponins from ginseng stems and leaves, and the theoretical tablet weight is 347 mg. Pass the raw and auxiliary materials through a 100-mesh sieve, take the total saponins of ginseng stems and leaves, lactose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone and magnesium stearate, mix well, and use 10.5 mm punch and press into tablets to obtain the orally disintegrating tablets of ginseng stem and leaf total saponins of the present invention, each containing 50 mg of ginseng stem and leaf total saponins, and the theoretical tabl...

Embodiment 2

[0024] According to the calculation of preparing 1000 tablets, the weight composition of raw materials is as follows: total saponins of ginseng stems and leaves 25g, lactose 58g, microcrystalline cellulose 130g, mannitol 38g, starch 20g, magnesium stearate 1g, made 1000 tablets altogether, tablet Specifications: Each tablet contains 25mg of total saponins from ginseng stems and leaves, and the theoretical tablet weight is 272mg. Pass the raw and auxiliary materials through a 100-mesh sieve respectively, take the total saponins of ginseng stems and leaves, lactose, microcrystalline cellulose, mannitol and starch in the formula, mix them evenly, and press into tablets to obtain the orally disintegrating tablet of total ginseng stems and leaves saponins of the present invention. Each tablet contains 25mg of total saponins from ginseng stems and leaves, and the theoretical tablet weight is 272mg.

[0025] Disintegration time limit Water is used as the medium, the dosage is less th...

Embodiment 3

[0027] According to the calculation of preparing 1000 tablets, the weight composition of raw materials is as follows: 50g of total saponins of ginseng stems and leaves, 150g of lactose, 100g of mannitol, 35g of cross-linked polyvinylpyrrolidone, an appropriate amount of 95% ethanol, and 3g of magnesium stearate, making 1000 tablets in total , Tablet specifications: Each tablet contains 50mg of total saponins from ginseng stems and leaves, and the theoretical tablet weight is 338mg. Pass the raw and auxiliary materials through a 100-mesh sieve respectively, take the total saponins of ginseng stems and leaves, lactose, mannitol and cross-linked polyvinylpyrrolidone in the prescribed amount, and mix them evenly; use 10-95% ethanol to make soft materials, granulate them with a 24-mesh sieve, wet Dry the granules at 50-60°C; granulate with a 24-mesh sieve, add magnesium stearate, mix well, and press into tablets with a 10.5mm punch to obtain the dispersible tablets of total saponins...

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Abstract

Disclosed is a quick-effective oral tablet in the form of oral disintegrating tablet and dispersible tablet, and its preparing process, wherein the raw materials comprise the following ingredients (by weight ratio): ginseng stems and leaves saponin 5-100, bulking agent 15-350, disintegrating agent 15-150, lubricant 1-10, and right amount of wetting agent or binding agent such as 10-95% of ethanol. Each tablet contains ginsenoside of stems and leaves 25mg or 50mg.

Description

1. Technical field [0001] An oral quick-acting tablet of total saponins from stems and leaves of ginseng includes orally disintegrating tablets and dispersible tablets and a preparation method thereof, relating to medicine [0002] technology field. 2. Background technology [0003] With the improvement of people's living standards and changes in lifestyles, cardiovascular and cerebrovascular diseases have become the primary disease that seriously endangers people's health, and the incidence rate is increasing year by year. At present, most of the available drugs are western medicines, and there are few traditional Chinese medicines, and most of the traditional Chinese medicine preparations are traditional or common dosage forms. In order to better develop our country's traditional resources and improve the internal quality and market competitiveness of Chinese medicine preparations It will be of great practical significance to reform the dosage forms of traditional Chinese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K31/704A61K9/20A61P9/00A61P9/10
Inventor 胡容峰汤继辉王琳琳陈光亮徐希平
Owner ANHUI PROV INST OF BIOLOGICAL MEDICINE
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