Composition for treating throat oral disease, preparation and preparing method

A technology for oral diseases and compositions, which are applied in the field of compositions for preventing and treating oral diseases of the throat, their preparations and their preparation, can solve the problems of insufficiently proven curative effect, insufficient curative effect, complicated formula and the like

Active Publication Date: 2006-07-05
GUANGXI GOLDEN THROAT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, CN 1421240 discloses a traditional Chinese medicine preparation for preventing and treating throat and oral diseases. A health care product for clearing the throat and moisturizing the throat. Its formula includes luohanhua, honeysuckle, etc. The taste of the health product has been improved, but its efficacy has not been fully verified
CN 1194804 discloses the preparation method of Gynostemma gynostemma Coke, which has the disadvantages of complicated formula, and its curative effect has not been fully confirmed.

Method used

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  • Composition for treating throat oral disease, preparation and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 - Preparation of the composition of the present invention

[0035] Take 11.8g of menthol, 6.3ml of eucalyptus oil, and 0.2ml of star anise oil, mix them well, and form a solution at room temperature.

[0036]Take 25.7g of green fruit, 17.1g of honeysuckle, 8.6g of Dendrobium, 1.7g of Luo Han Guo, and 1.7g of orange red, put them in a container, add water to boil three times, add about 620g of water each time, and cook for about 2 hours each time. The decoction obtained by decocting for three times was combined, filtered, and the filtrate was vacuum concentrated into an extract. The relative density of the obtained extract is 1.27-1.32 / 80°C.

[0037] Mix the above solution with the extract to obtain the composition of the present invention.

Embodiment 2

[0038] The preparation of embodiment 2-buccal tablet preparation of the present invention

[0039] Mix 1132g of sucrose and 1087g of 78% liquid glucose with about 400ml of water evenly. Open the steam valve and heat to fully dissolve the sucrose. During the whole process, the steam pressure is controlled within the range of 0.2-0.3 MPa, and the solid matter content of the obtained syrup is about 80% by weight.

[0040] Concentrate the syrup in vacuum, evaporate excess water, control the temperature in the evaporation process above 135-155° C., and hydraulic pressure 7.5-8.5 MPa. Finally, the material becomes a massecuite of more than 97% by weight.

[0041] The massecuite was thoroughly mixed with the composition in Example 1 to obtain a thick paste, which was cooled to 85-95°C. Then, enter the forming machine to form, make 1000 pieces, and pack.

Embodiment 3

[0042] Example 3 - Compositions of the invention against o 2 - free radical scavenging

[0043] In this experiment, a xanthine-xanthine oxidase-luminol luminescence system was established as the O 2 - The generation model and detection means of free radicals are used to detect the scavenging ability of the composition obtained in Example 1 to exogenous free radicals.

[0044]

[0045] Add 100 μl xanthine oxidase (0.1zu / ml) in the measurement tube, and the test solution of the composition of the embodiment 1 of 20 μl different concentrations (in terms of composition, the concentration is respectively 0 (control group), 5, 10, 15, 20, 25 (dosing group) mg / ml, prepared with phosphate buffer). Trigger the reaction with 1ml of xanthine-luminol (1:2) mixture, record the total value of chemiluminescence F(t) within 20 seconds, and calculate the percent inhibition according to the following formula:

[0046] Inhibition %=[(CL value of control group-CL value of dosing group)...

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Abstract

A medicinal composition for preventing and treating the diseases of oral cavity and throat, especially the chronic pharyngolaryngitis is prepared from 8 Chinese-medicinal materials including menthol, cucalyptus oil, anise oil, honeysuckle flower, etc. A food containing said medicinal composition is also disclosed.

Description

technical field [0001] The invention relates to a composition for preventing and treating throat and oral diseases, especially chronic pharyngitis, its preparation and its preparation method. The pharmaceutical composition is made of the following raw materials: 4-18 parts by weight of menthol, 2.7- 8.2 parts by weight of eucalyptus oil, 0.1-0.3 parts by weight of star anise oil, 13-38 parts by weight of green fruit, 9-25 parts by weight of honeysuckle, 4-13 parts by weight of Dendrobium, 0.8-2.5 parts by weight of Luo Han Guo and 0.8-2.5 parts by weight of orange. The invention also relates to a food product comprising the composition described above. Background technique [0002] Throat and oral diseases belong to the category of "milk moth, throat numbness, and throat dullness" in traditional Chinese medicine, and belong to the Department of Articulation and Throat. Representative throat and oral diseases such as acute and chronic pharyngitis, acute tonsillitis, oral ul...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61K9/00A61P1/02A61P11/04
Inventor 江佩珍
Owner GUANGXI GOLDEN THROAT
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