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Chinese medicine composition for treating diabetes mellitus

A technology of traditional Chinese medicine preparations and compositions, which is applied in the field of traditional Chinese medicine compositions for treating diabetes, and can solve the problems of high impurities, uncontrollable quality, and low content of total paeony glycosides, etc., and achieve less dosage, lower production costs, and less toxic and side effects Effect

Active Publication Date: 2006-05-31
北大世佳科技开发有限公司
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  • Application Information

AI Technical Summary

Problems solved by technology

The traditional preparation methods of total glucosides of paeony reported in the literature include water extraction, alcohol extraction, and water extraction and alcohol precipitation. Due to the complex composition of red peony medicinal materials and non-glycoside components, the traditional preparation methods include red peony Disadvantages such as low total glycoside content, high impurities, and uncontrollable quality

Method used

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  • Chinese medicine composition for treating diabetes mellitus
  • Chinese medicine composition for treating diabetes mellitus
  • Chinese medicine composition for treating diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] [Example 1] The preferred preparation method of total glucosides of paeony

[0117] Take 200 g of Radix Paeoniae Rubra (Paeoniflorin monomer content is 3.61%), pulverize into a coarse powder, and reflux extract with 70% ethanol three times, each time for 1 hour, adding 8 times the weight and volume of the medicinal material each time. Recover ethanol from the alcohol extract under reduced pressure to a concentrated solution with a relative density of 1.08 (60°C), add water twice the weight of the crude drug, stir evenly, filter, and the filtrate is 0.2mL / cm 2 .min passes through ZTC-1 saponin adsorption resin column (resin aspect ratio 8: 1, resin dosage is 3.75 times of medicinal material weight), first washes with 10 times of resin volume, then uses 6 times of resin weight with 20% ethanol 1mL / cm 2 .min speed elution, the alcohol eluate was concentrated under reduced pressure, dried under reduced pressure, and pulverized to obtain 11.36g of total glucosides of paeony...

Embodiment 2

[0118] [Example 2] The preferred preparation method of total glucosides of paeony

[0119] Get 120kg of Radix Paeoniae Rubra (Paeoniflorin monomer content is 3.61%), reflux extraction with 8 times the amount (v / w) of solvent 70% ethanol for 3 times, each extraction for 1 hour. The extract was concentrated under reduced pressure to obtain ethanol extract (relative density 1.08 at 60°C). Add 2 times the water of medical material weight to make extractum dissolve, filter, and filtrate slowly passes through saponin resin column (the weight of saponin resin is 3.75 times of medical material), and the control flow velocity is 120L / m . h. After passing through, wash away the remaining impurities in the column with water 8 times the weight of the saponin resin, and then desorb with 20% ethanol 6 times the volume of the saponin resin. The desorbed solution was collected, concentrated under reduced pressure and dried under reduced pressure to obtain 6.53 kg of total glucosides of paeo...

Embodiment 3

[0120] [embodiment 3] the preparation method of preferred dosage form capsule of the present invention

[0121] Take 100 g of the dried (60° C.) treated total glucosides of paeony extract, grind and pulverize, and pass through an 80-mesh sieve. Add 98g of starch and 2g of magnesium stearate passed through an 80-mesh sieve, mix evenly, divide into 1000 capsules of 3# (200mg / capsule), pack in aluminum-plastic compound, and get final product. Each capsule of this product contains paeoniflorin (C 23 h 28 o 11 ), should not be less than 50.0mg. Take orally, 2 capsules at a time, three times a day.

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Abstract

A Chinese medicine for treating diabetes features that its main component is the red peonyí»s glycoside extracted from red peony root. Its preparing process and the forms of its product are also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating diabetes, in particular to extracting total glucosides of paeony from the traditional Chinese medicine Radix Paeoniae Rubra as an effective component of the medicine, and the medicine is effective in treating diabetes. The invention also provides a preparation method of the medicine and its corresponding pharmaceutical dosage form and application. Background technique [0002] Diabetes is a common endocrine-metabolic disease, which is distributed all over the world and is gradually increasing. The prevalence of diabetes in my country has reached 10.50%. Although it is not high compared with foreign developed countries, due to the population It has the second largest population of diabetic patients in the world, second only to the United States, and is growing at a rate of doubling every 15 years. Diabetic patients in my country are mainly type II, but their onset is often h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61P3/10
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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