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Active drug delivery in the gastrointestinal tract

A gastrointestinal tract and drug technology, applied in the field of ingestible capsules, can solve the problems that the drug is not easy to dissolve quickly, the bioavailability becomes low, and the bioavailability of the drug is affected.

Inactive Publication Date: 2006-05-17
PILL PHARMA E
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the drug is not readily soluble or penetrates the epithelial membrane quickly, its bioavailability will be low
Age, sex, activity, genetic phenotype, stressful state, disease (eg, achlorhydria, malabsorption syndrome), or previous GI surgery can further affect drug bioavailability

Method used

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  • Active drug delivery in the gastrointestinal tract
  • Active drug delivery in the gastrointestinal tract
  • Active drug delivery in the gastrointestinal tract

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0423] An electrically assisted drug delivery device 10 .

[0424] Active drug: insulin.

[0425] Filler: microcrystalline cellulose, lactose.

[0426] Protease inhibitors: chymostatin, trypsin inhibitor.

[0427] The components are mixed and compressed into tablets. An enteric coating is used to protect it from the gastric environment. Acrylic L can be used.

example 2

[0429] Similar to Example 1, but additionally includes an absorption enhancer such as capric acid.

example 3

[0431] Oral capsules for Kepasone prepared in Example 1. The components are dry blended and filled into capsules coated with an enteric coating polymer like HPMCP.

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Abstract

The invention provides a device (100) for administering a medicament (36, 136) comprising an ingestible capsule (30, 102). The capsule (30, 102) includes a drug (36, 106) stored by the capsule (30, 102). The environmentally sensitive mechanism (eg, coating 104) is adapted to change the state of the capsule (30, 102) in response to its deployment within the subject's gastrointestinal tract. The drive mechanism (eg, drive mechanism 108) is adapted to drive the drug (36, 106) directly through the endothelial layer of the gastrointestinal tract in response to a change in state of the environmentally sensitive mechanism.

Description

[0001] Cross-references to related applications [0002] This application claims the benefit of US Provisional Patent Application 60 / 443,173, filed January 29, 2003, which is hereby incorporated by reference. technical field [0003] The present invention relates to oral drug delivery systems, and more particularly to an ingestible capsule which acts as a drug carrier and enhances the absorption of the drug through the gastrointestinal wall. Background technique [0004] Absorption of a drug (or prodrug) into the systemic circulation is determined by the physicochemical properties of the drug, its composition, and the route of administration (oral, rectal, topical, by inhalation, or intravenously) . Oral administration includes swallowing, chewing, sucking, and buccal administration, which places the drug between the gum and cheek, and sublingual administration, which places the drug under the tongue. Absorption requires dissolution of the drug. [0005] Absorption of ora...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61B5/00A61B5/07A61J3/07A61K9/00A61M31/00
CPCA61B1/041A61B5/0008A61B5/01A61B5/073A61B5/14532A61B5/14539A61B5/14546A61B5/42A61B5/4839A61J3/07A61K9/0004A61K9/0009A61K9/0097A61M31/002A61N1/30A61N1/306A61N1/325A61K9/20A61K9/48
Inventor 约西·格罗斯约拉姆·塞拉
Owner PILL PHARMA E
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