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Pharmaceutical composition for treating ulcerative colitis, its preparation method and use

A technology for ulcerative colitis and composition, applied in the field of traditional Chinese medicine, to achieve the effect of definite curative effect, novel dosage form, and small dosage

Inactive Publication Date: 2006-05-10
杨明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it has been reported that the traditional Chinese medicinal materials Astragalus and Sophora flavescens are used simultaneously to treat other diseases, or used separately to treat ulcerative colitis, there is no relevant report on the combined use of the two raw materials to treat ulcerative colitis.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Preparation of pharmaceutical granules of the present invention

[0040] Take 1333g of Astragalus and add 12 times the amount of water, soak for 0.5 hour, decoct three times for 2 hours each time, and concentrate the extract under reduced pressure to a relative density of 1.15g / ml to obtain Astragalus concentrate. In addition, 1556 g of Sophora flavescens was extracted with 6 times the amount of 60% ethanol and refluxed for 3 times for 2 hours each time. The obtained extract was decompressed to recover ethanol and concentrated to a relative density of 1.15 g / ml to obtain Sophora flavescens concentrate. Mix the Astragalus concentrate and Sophora flavescens concentrate according to the prescription amount, add appropriate amount of sucrose and dextrin to make soft material, pass through No. 1 sieve to granulate, the wet granules obtained are dried at 50℃, pass No. 1 sieve, and then packed into finished products 1000g.

[0041] Specification: 15g / bag, each bag is equ...

Embodiment 2

[0042] Example 2 Preparation of pharmaceutical pills of the present invention

[0043] Take 200g of Astragalus and Sophora flavescens 200 with 12 times the amount of water, soak for 0.5 hour, decoct three times for 2 hours each time, and concentrate the obtained extract under reduced pressure to a relative density of 1.12g / ml to obtain astragalus concentrate. Sophora flavescens 100g slices are dried at 60°C and crushed through a No. 5 sieve to obtain Sophora flavescens powder. Sophora flavescens powder is pan-formed into pills with astragalus clear ointment, and dried at 50°C to obtain 1000 pills of the present invention.

[0044] Specification: 0.16g / pill, each pill is equivalent to 0.2g of Astragalus crude drug and 0.3g of Kushen crude drug.

Embodiment 3

[0045] Example 3 Preparation of pharmaceutical tablets of the present invention

[0046] Take 200g of Astragalus and 300g of Sophora flavescens to prepare thick extract of Astragalus and Sophora flavescens according to the method in Example 1. Add appropriate amount of starch, boil and granulate to obtain dry granules, add appropriate amount of talcum powder, mix well, press tablets, and coat 1000 pharmaceutical tablets of the present invention were obtained. The tableting process parameters are: rotation speed 25 rpm, tableting pressure 12N; coating process parameters: inlet air temperature is 70℃, outlet air temperature is 30~35℃, tablet bed temperature is 35~40℃, coating The rotating speed of the pan is 6 rpm, and the 18%-22% Opadry aqueous solution is sprayed at the speed of 114ml / min, and the dosage is 3% of the total weight of the plain tablets.

[0047] Specification: 0.5g / tablet, each tablet is equivalent to 1.25g Astragalus crude drug and 1.92g Kushen crude drug.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating ulcerative colitis, which is prepared from astragalus root and flavescent sophora root as the raw material. the invention also provides the method for preparation and use of the pharmaceutical composition.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating ulcerative colitis, specifically, a pharmaceutical composition prepared by using Chinese medicinal materials as raw materials, and a preparation method and application thereof, belonging to the field of Chinese medicine. Background technique [0002] Ulcerative colitis is a primary, non-specific chronic disease of the colon. Under colonoscopy, it can be seen that only the mucosa and submucosa of the colon are invaded, and there are erosions and superficial ulcers. [0003] At present, Western medicine treatment of ulcerative colitis mainly includes the following types of drugs: sulfonamides, antibiotics, metronidazole, hormone therapy, oral corticosteroids, topical administration, immunosuppressive agents; the above-mentioned western medicines have passed long-term efficacy trials and clinical trials All have proven to have reliable therapeutic effects, but most of them are highly toxic and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K9/02A61P1/00A61P1/04
Inventor 杨明谢兴亮邱雪兰肖禾
Owner 杨明
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