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Finely prepared sustained-releasing formulation for coronary disease and preparation process thereof

A technique for slow-release preparations of coronary heart, which is applied in the field of refined coronary heart sustained-release preparations and its preparation, and can solve the problems of large dosage of refined coronary heart tablets and backward process conditions, etc.

Inactive Publication Date: 2006-02-22
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The refined Guanxin Tablets recorded in the 2005 edition of the Pharmacopoeia of the People's Republic of China has a large dosage, 6 to 8 tablets at a time, 3 times a day, the technological conditions are backward, and there is no quantitative detection index

Method used

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  • Finely prepared sustained-releasing formulation for coronary disease and preparation process thereof
  • Finely prepared sustained-releasing formulation for coronary disease and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Extract and separate the various medicinal materials in the refined Guanxin formula, for example: extract the effective fraction group mainly composed of Danshensu by water extraction and alcohol precipitation method and / or other methods; use water extraction and alcohol precipitation method and / or 50%-98% After extraction with concentrated ethanol (including water), use macroporous resin separation method and / or other methods to extract the active fraction group mainly based on paeoniflorin; Porous resin separation method and / or other methods to extract the effective fraction group mainly composed of ferulic acid; after extraction with water extraction and alcohol precipitation method and / or different concentrations of ethanol (including water), use macroporous resin separation method and / or other methods Extract the active part group mainly composed of safflower yellow pigment; extract the volatile oil of balsamic balm by steam distillation and / or other methods, and in...

Embodiment 2

[0040] Each medicinal material in the refined Guanxin formula is extracted and separated with reference to Example 1, and the tablet of Example 2 made by a method known in the pharmaceutical industry contains the following ingredients by weight percentage:

[0041] Salvia Extract 23.0%

[0042] Paeoniae Rubra Extract 5.4%

[0043] Chuanxiong Extract 1.2%

[0044] Safflower Extract 11.5%

[0045] Aroma essential oil-β-cyclodextrin inclusion complex 7.9%

[0046] Bergamot Extract 0.7%

[0047] Carbopol 32.9%

[0048] Lactose 16.4%

[0049] Magnesium Stearate 1.0%

[0050] 60% ethanol solution appropriate amount

Embodiment 3

[0052] Each medicinal material in the refined Guanxin formula is extracted and separated with reference to Example 1, and the present Example 3 tablet made by a method known in the pharmaceutical industry contains the following ingredients by weight percentage:

[0053] Salvia Extract 27.5%

[0054] Radix Paeoniae Alba Extract 6.5%

[0055] Chuanxiong Extract 1.5%

[0056] Safflower Extract 13.8%

[0057] Aroma essential oil-β-cyclodextrin inclusion complex 9.5%

[0058] Bergamot Extract 0.8%

[0059] Sodium Alginate 35.5%

[0060] Calcium Alginate 3.9%

[0061] Magnesium Stearate 1.0%

[0062] 75% ethanol solution appropriate amount

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PUM

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Abstract

The invention relates to finely prepared sustained-releasing formulation for coronary disease and preparation process, whose constituents (percentage by weight) are, root of red rooted saliva, radix paeoniae rubrathe, Ligusticum wallichii, safflower herbs and / or extract 10-80%, adjuvant for slow release action 20-90%, and balancing medicinal auxiliary materials.

Description

Technical field: [0001] The present invention relates to a sustained-release preparation containing medicinal materials and / or extracts such as Salvia miltiorrhiza, Radix Paeoniae Rubra, Chuanxiong, safflower, and Dalbergia basilica. Specifically, it is a refined coronary heart sustained-release preparation and its preparation method, which is used for treating cardiovascular disease. Coronary heart disease due to blood stasis, angina pectoris. technical background: [0002] Traditional Chinese medicine has a long history, and there are a large number of compound prescriptions with definite curative effects. However, at present, most of the drug dosage forms are still in common preparations, and there are very few sustained-release traditional Chinese medicine preparations with high efficiency, long-acting effect and small dosage. With the development of excipients, the application of technology and the advanced preparation technology of traditional Chinese medicine, it has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/22A61P9/10
Inventor 潘卫三杨星钢彭博张志宏
Owner SHENYANG PHARMA UNIVERSITY
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