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Medicinal composition contg. glucoside of pueravia flower and its application

A technology of puerarin and composition, applied in the application field of plant extract puerarin in the preparation of new drugs, which can solve the problems of affecting drug availability and significant time, inconvenient selection and use, low water solubility, etc.

Inactive Publication Date: 2006-01-25
INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Due to the low water solubility of puerarin, when it is used as medicine, it can only be made into oral preparations and cannot be made into injections. Because of their low water solubility, it affects the drug availability and significant time, and is not convenient for clinical selection.

Method used

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  • Medicinal composition contg. glucoside of pueravia flower and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0163] Embodiment 1. The preparation of puerarin

[0164] In this example, 10 kg of dried Pueraria mirifica was crushed, extracted twice with 90% ethanol solution under reflux, each time for 3 hours, filtered, the filtrate was collected, the ethanol was recovered until there was no alcohol smell, 6 times the amount of water was added to the solution, and left overnight , take the supernatant. Pass through the macroporous resin, elute with 60% ethanol, recover the eluent, place it to precipitate crystals, filter, dry, recrystallize with acetone, and filter to obtain pueraria glycoside.

example 2

[0166] Taking the preparation of 1000 puerarin injections as an example, the ratio of raw materials and auxiliary materials used is as follows:

[0167] Pueraria glycosides 100g

[0168] Hydroxypropyl-β-cyclodextrin 500g

[0169] Sodium Calcium Edetate 1g

[0170] Sodium bisulfite 10g

[0171] Add water for injection to 10L

[0172] It is made by the conventional injection preparation process, and each bottle weighs 10 orders and 10ml, and each bottle contains 100mg of puerarin. Usage: Once a day for adults, 6 vials for intravenous injection each time, reduce the dose for children as appropriate.

example 3

[0174] Taking the preparation of 100ml puerarin injection, 1000 bottles as an example, the ratio of raw materials and auxiliary materials used is as follows:

[0175] Pueraria glycosides 1000g

[0176] Hydroxypropyl beta cyclodextrin 3000g

[0177] Sodium Calcium Edetate 1g

[0178] Sodium bisulfite 10g

[0179] Add water for injection to 10L

[0180] It is made by the conventional injection preparation process, and each bottle is 100ml, and each bottle contains 1mg of puerarin. Usage: 1 bottle of intravenous injection for adults once a day, and reduce the dose for children as appropriate.

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PUM

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Abstract

A medicinal puerarin composition used for preparing the medicine to treat the cardiovascular and cerebrovascular diseases and osteoporosis is prepared from puerarin and solubilizing agent chosen from hydroxy propyl-beta-cyclodextrin, beta-cyclodextrin and hydroxyethyl-beta-cyclodextrin. It has high water-solubility.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, and relates to the application of a plant extract puerarin in the preparation of new medicines. Background technique [0002] Flos Puerariae, also known as Pueraria Lobata (Willd.) Ohwi, is the dried flower bud of Pueraria Lobata (Willd.) Ohwi, a plant of the family Leguminosae. Cool in nature, sweet in taste, enters Gui Yang Ming Jing. "Shen Nong's Materia Medica", "Compendium of Materia Medica", etc. record that it has the effect of relieving alcohol and refreshing the spleen. [0003] It has been reported in the literature that Pueraria kudzu extract can significantly increase the activity of Gu / ZnSOD and CAI (catalase) in the rat model treated with ethanol, reduce the activity of G-SH-PX (glutathione peroxidase), and make The NRNA levels of these antioxidant enzymes and the liver GSH return to normal, reduce the MAD level, and protect the liver. Pueraria also has the effect of p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61K31/7048A61P19/10A61P9/00
Inventor 仲英左春旭王元书刘鲁谢砚英王菊孙敬勇
Owner INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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