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Medical intelligent nano-gel material and its preparation method

A nanogel and intelligent technology, which is applied in the field of medicinal intelligent nanogel materials and their preparation, medicinal gel materials and their preparation, can solve the problems of unsuitable for medicinal use, poor mechanical properties, slow gel response speed, etc. problem, to achieve good environmental stimulus responsiveness and small size

Inactive Publication Date: 2006-01-11
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above-mentioned existing gel materials have certain advantages, but also have many disadvantages to be solved, such as slow response speed, poor mechanical properties, and a large amount of harmful solvent residues, which are not suitable for medicinal use.

Method used

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  • Medical intelligent nano-gel material and its preparation method

Examples

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Effect test

Embodiment 1

[0026] Example 1: Aqueous phase synthesis of dextran / acrylic acid nanogels

[0027] Dissolve 1.5g of dextran in 100ml of deionized water, put it in a 250ml three-neck flask, let it stand for 24 hours, add 1ml of epichlorohydrin dropwise under constant stirring, react at 30°C for 48h, and finally precipitate cross-linked dextran with acetone Nanoparticles, vacuum-dried after centrifugal separation, dispersed in 100ml deionized water, 3ml of acrylic acid was added to the suspension, and then N 2 Gas for 30min, continue to add 1.0g N,N'-methylenebisacrylamide (Bis), 0.1g ammonium persulfate (APS) and 1 drop of tetramethylethylenediamine (TEMED) respectively, stop the reaction after 2h, put The core-shell nanoparticle is centrifugally separated from the reaction liquid, and dried in a vacuum oven.

Embodiment 2

[0028] Embodiment 2: prepare dextran / acrylic acid nanogel in mixed solvent

[0029] Dissolve 2.5g of dextran in a mixed solvent of 100ml deionized water and acetone, let it stand for 24 hours, slowly add 2ml of acrylic acid dropwise to the system, and then pour N into the solution. 2 Gas for 30min, continue to add 1.0g N,N'-methylenebisacrylamide (Bis), 0.2g ammonium persulfate (APS) and 2 drops of tetramethylethylenediamine (TEMED) respectively, stop the reaction after 4h, put The core-shell nanoparticle is centrifugally separated from the reaction solution, and dried in a vacuum drying oven to obtain a dry powder.

Embodiment 3

[0030] Embodiment 3: Preparation of hydroxypropylmethylcellulose / acrylic acid nanogel

[0031]Take 5g of hydroxypropylmethylcellulose and dissolve it in 100ml of deionized water, then add acetone to the solution until the system just appears turbid and white, and let it stand for 24 hours; continue to add 2ml of acrylic acid to the system, and then pour N into the solution. 2 Gas for 30min, continue to add 1.0g N,N'-methylenebisacrylamide (Bis), 0.3g ammonium persulfate (APS) and 2 drops of tetramethylethylenediamine (TEMED) respectively, stop after 4h of reaction, put The core-shell nanoparticle is centrifugally separated from the reaction liquid, and dried in a vacuum oven.

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Abstract

An intelligent nano-gel for medicine has a core-shell structure composed of temp-sensitive high-molecular polyose as core and pH-sensitive acrylic polymer as shell, and is prepared through adding acrylic acid or its derivative to the aqueous suspension of polyose nanoparticles, filling N2, deoxidizing, adding cross-linking agent and trigger, and reaction. It has high response speed to the variation of temp and pH value.

Description

1. Technical field [0001] The invention relates to a medicinal polymer material and a preparation method thereof, in particular to a medicinal gel material and a preparation method thereof, in particular to a medicinal intelligent nano gel material and a preparation method thereof. 2. Background technology [0002] Smart gel materials are a class of materials whose volume or pore size changes drastically in response to changes in the external environment such as temperature, pressure, pH, electric field, and magnetic field. Smart gel materials have important applications in the controlled release of drugs, the immobilization of active enzymes and cells, and the separation and purification of active biomacromolecules, and have become a research hotspot in the field of materials in recent years. Among them, the temperature-sensitive hydrogel represented by poly-N-isopropylacrylamide (PNIPAm) is the most in-depth study, and its lower critical solution temperature (LCST) is 32°C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/00C08L33/00C08K5/20A61K47/36
Inventor 姚日生徐玉福邓胜松
Owner HEFEI UNIV OF TECH
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