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Compound traditional Chinese medicine for treating acute gastroenteritis and anti-influenzavirus, and its prepn. method

An anti-influenza virus, compound preparation technology, applied in the direction of antiviral agents, medical preparations containing active ingredients, pharmaceutical formulations, etc., to achieve the effect of inhibiting pepsin activity, promoting gastric emptying, and reducing gastric juice and gastric acid secretion

Inactive Publication Date: 2006-01-11
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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AI Technical Summary

Problems solved by technology

The traditional Chinese medicine "Buhuan Jinzhengqi Powder" is extracted and refined with CO2 supercritical fluid extraction technology, and the active ingredients are tracked with pharmacodynamic screening indicators; and the new preparation developed will have unexpected good effects

Method used

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  • Compound traditional Chinese medicine for treating acute gastroenteritis and anti-influenzavirus, and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0011] Experimental Example 1 The main pharmacodynamic research results of Huangqin Zhengqi Capsules in the treatment of acute gastrointestinal inflammation.

[0012] During the experiment, the animals were randomly divided into groups, and the normal or model group was set as the blank control, and the Huoxiangzhengqi pill, which was basically similar in efficacy to the main treatment, was selected as the positive drug control. The relevant experiments included aspirin, atropine, imodium, acetylcholine, and morphine. , Ranitidine as the positive drug control, to ensure the reliability of the test method. Three dosage groups were established respectively according to 5 times, 10 times, 20 times and 30 times of the clinical dose of the tested drug (5 times, 10 times and 20 times for rats and domestic pigeons, 10 times, 20 times and 30 times for mice). times).

[0013] The test results showed that Huangqin Zhengqi Capsules had obvious inhibitory effects on rats with pyloric lig...

experiment example 2

[0015] Experimental Example 2 Anti-influenza Virus Test of Huangqin Zhengqi Capsules in Vitro

[0016] 1 material

[0017] 1.1 Drugs: the test product Scutellaria Zhengqi Capsules SFE-CO2 extract, dissolved in DMSO into a 20mg / ml solution for subsequent use; Bavirin injection (100mg / ml), batch number 031119, Shanghai General Pharmaceutical Co., Ltd.

[0018] 1.2 Test strains and sensitive cells: influenza virus A / Shenzhen / 1 / 99 (H3N2) (type A); B / Jingfang / 184 / 93 (type B); avian influenza virus A / Goose / GD / 2 / 96(H5N1) were provided by Shenzhen Center for Disease Control. MDCK cells (dog kidney cells) were provided by the China Center for Disease Control and were resuscitated and subcultured to make monolayer cells.

[0019] 1.3 Reagents: RPMI1640 cell growth medium (containing 10% newborn bovine serum, penicillin 100IU / ml, streptomycin 100ug / ml); RPMI1640 cell maintenance medium (containing penicillin 100IU / ml, streptomycin 100ug / ml).

[0020] 1.4 Chicken blood cell suspensio...

experiment example 3

[0045] Experimental Example 3 Pharmacodynamic Study of Huangqin Zhengqi Capsules in Treating Colds

[0046] This material observes the antiviral, antibacterial, anti-inflammatory, antipyretic and effects on immune function of Huangqin Zhengqi Capsules. Antiviral experiments in mice showed that Huangqinzhengqi Capsules (medium and high doses) could significantly inhibit the increase of lung index in virus-infected mice. Antiviral experiments in vitro proved that the inhibitory indices on the proliferation of respiratory syncytial virus, adenovirus type 3 and Coxsackie virus group B virus type I were 8, 4 and 1, respectively. The inhibitory indices of the positive control drug Kangganjiedu Granules on the proliferation of the three viruses were 4, 4 and 2, respectively. Compared with the two, there was no significant difference in the effect of inhibiting the virus in vitro.

[0047] Antibacterial experiments in vitro showed that Huangqin Zhengqi Capsules had different degrees...

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Abstract

A Chinese medicine for treating acute enterogastritis and preventing and treating viral influenza is prepared from 7 Chinese-medicinal materials including atractylodes rhizome, magnolia bark, tangerine peel, pinellia, etc through supercritical CO2 fluid extracting, refining, and preparing orally taken form, aerosol, or injection.

Description

technical field [0001] The invention relates to a compound preparation drug, in particular to a compound preparation for treating acute gastroenteritis and anti-influenza virus and a preparation method thereof. Background technique [0002] Currently commonly used Chinese patent medicines are difficult for consumers to accept due to backward drug production technology, insufficient scientific and technological content, and rough dosage forms; the heating process for a long time leads to the destruction of heat-sensitive active ingredients. Chinese medicine has a unique curative effect on the treatment of influenza. "Bu Huan Jin Zheng Qi San" comes from "Tai Ping Hui Min He Ji Ju Prescription". Influenza (a type of influenza). The traditional Chinese medicine "Buhuan Jinzhengqi Powder" is extracted and refined with CO2 supercritical fluid extraction technology, and the active ingredients are tracked with pharmacodynamic screening indicators; and the new preparation develope...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61K9/48A61P1/04A61P31/16
Inventor 苏子仁赖小平陈建南
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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