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Compound notoginseng injection and its preparation process

A technology of compound notoginseng and injections, which is applied in the fields of pharmaceutical formulations, medical preparations containing active ingredients, powder delivery, etc., and can solve problems such as high water solubility, poor permeability, and low bioavailability of oral preparations

Inactive Publication Date: 2005-11-23
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

PNS is extremely water-soluble, and has poor permeability from the gastrointestinal tract to the mucous membrane. The strong acid environment in the stomach and the strong alkali environment in the intestinal tract also have a strong degradation effect on the drug, and the active monomers are very easy to be gastrointestinal enzymes and intestinal tract. Bacterial metabolism, thus leading to low bioavailability of oral formulations, where Rb 1 The oral absolute bioavailability of Rg1 is only 4.35%, the oral bioavailability of Rg1 is 18.40%, and it is eliminated quickly in the blood
Moreover, most of the efficacy of PNS comes from the original drug, rather than the product after metabolism or degradation, so oral administration is not a suitable route of administration for PNS.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] The preparation method of injection of the present invention:

[0071] Get fresh Radix Notoginseng 170g, Radix Ginseng 20g, Radix Puerariae Puerariae 14g and be ground into coarse powder, according to the percolation method (an appendix 10 of a pharmacopoeia of version in 2000) under the liquid extract and the extract item, make solvent with 60% ethanol, slowly percolate, Recover ethanol from the filtrate, let it stand for 48 hours, filter, concentrate the filtrate to a clear paste with a relative density of 1.2 (50-60°C), take 100 g of astragalus and add water to decoct three times, each time for 2.5 hours, filter, and concentrate the filtrate to a relative density 1.30 (50-60°C) clear ointment, add an equivalent amount of 60% ethanol, let it stand for 48 hours, filter, the filtrate is concentrated to a relative density of 1.20 (50-60°C) clear ointment, add ethanol to the clear ointment 80%, let it stand for 24 hours, filtered, and the ethanol was recovered from the fi...

Embodiment 2

[0073] The preparation method of freeze-dried powder injection of the present invention:

[0074] Get fresh Radix Notoginseng 680g, Radix Ginseng 80g, Radix Puerariae Puerariae 56g and be pulverized into coarse powder, according to the percolation method (appendix 10 of a pharmacopoeia of version in 2000) under the liquid extract and extract item, make solvent with 60% ethanol, slowly percolate, Recover ethanol from the filtrate, let it stand for 48 hours, filter, concentrate the filtrate to a clear paste with a relative density of 1.2 (50-60°C), take 400 g of Astragalus membranaceus and add water to decoct three times, each time for 2.5 hours, filter, and concentrate the filtrate to a relative density 1.30 (50-60°C) clear ointment, add an equivalent amount of 60% ethanol, let it stand for 48 hours, filter, the filtrate is concentrated to a relative density of 1.20 (50-60°C) clear ointment, add ethanol to the clear ointment 80%, let it stand for 24 hours, filtered, and the eth...

Embodiment 3

[0076] The preparation method of concentrated solution for injection of the present invention:

[0077] Get fresh Radix Notoginseng 170g, Radix Ginseng 20g, Radix Puerariae Puerariae 14g and be ground into coarse powder, according to the percolation method (an appendix 10 of a pharmacopoeia of version in 2000) under the liquid extract and the extract item, make solvent with 60% ethanol, slowly percolate, Recover ethanol from the filtrate, let it stand for 48 hours, filter, concentrate the filtrate to a clear paste with a relative density of 1.2 (50-60°C), take 100 g of astragalus and add water to decoct three times, each time for 2.5 hours, filter, and concentrate the filtrate to a relative density 1.30 (50-60°C) clear ointment, add an equivalent amount of 60% ethanol, let it stand for 48 hours, filter, the filtrate is concentrated to a relative density of 1.20 (50-60°C) clear ointment, add ethanol to the clear ointment 80%, let it stand for 24 hours, filtered, and the ethanol...

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PUM

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Abstract

The invention relates to a compound notoginseng injection and its preparation process, wherein the injection is prepared from (by weight ratio) the following raw materials, notoginseng 425-1700 parts, astragalus root 250-1000 parts, ginseng 50-200 parts, kudzuvine root 35-140 parts.

Description

Technical field: [0001] The invention relates to the preparation of a traditional Chinese medicine injection, in particular to a Chinese medicine compound Sanqi injection preparation and a preparation method thereof. Background technique: [0002] "Compound Sanqi Oral Liquid" is also known as: Qixuekang Oral Liquid. Its functions and indications are: anti-aging, strengthening the body, nourishing Qi and strengthening the heart, invigorating the spleen and strengthening the body, nourishing yin and moistening dryness, promoting body fluid and relieving cough; and improving the body's immunity Force, increase the role of white blood cells and hemoglobin. It is used for fatigue, shortness of breath, palpitations, deficiency of yin and lack of body fluid, dry mouth and tongue; it is also used for all deficiency syndromes after radiotherapy and chemotherapy in tumor patients. However, as oral administration, due to poor absorption in the gastrointestinal tract, liver first-pass ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 刘鸿林刘智谋
Owner FUKANGREN BIO PHARMA
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