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Oral disintegration tablet of Amlodipine mesylate, and preparation method

A technology of amlodipine mesylate and orally disintegrating tablets, which is applied to pharmaceutical formulas, medical preparations containing active ingredients, pill delivery, etc., to achieve the effect of easy packaging, carrying and taking

Inactive Publication Date: 2005-11-16
HANGZHOU MINSHENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But they are all ordinary tablets, taste bitter, and need to be taken with water

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The formulation of the present invention consists of the following components by weight percentage:

[0029] Amlodipine mesylate 5.0g

[0030] Microcrystalline Cellulose 50.0g

[0031] Mannitol 100.0g

[0032] Cross-linked polyvinylpyrrolidone 9.0g

[0033] Sodium bicarbonate 4.0g

[0034] Citric acid 4.0g

[0035] Aspartame 1.5g

[0036] Mint essence 0.56g

[0037] Orange flavor 1.0g

[0038] Micronized silica gel 2.0g

[0039] Magnesium Stearate 1.0g

[0040] A total of 1000 pieces were made

[0041] The dosage form is prepared by direct compression technology using conventional tablet pharmaceutical equipment. The specific preparation method is as follows: Amlodipine mesylate, microcrystalline cellulose, mannitol, cross-linked polyvinylpyrrolidone, sodium bicarbonate, citric acid, aspartame, peppermint essence, orange essence are respectively Weigh, pass through an 80-mesh sieve and mix evenly; then mix with magnesium stearate and micropowder silica gel, s...

Embodiment 2

[0043] The formulation of the present invention consists of the following components by weight percentage:

[0044] Amlodipine mesylate 5.0g

[0045] Fast flowing lactose (Flowlac  ) 150.0g

[0046] Croscarmellose Sodium 9.0g

[0047] Aspartame 1.8g

[0048] Mint essence 0.5g

[0049] Magnesium Stearate 1.0g

[0050] A total of 1000 pieces were made

[0051] The dosage form is prepared by direct compression technology using conventional tablet pharmaceutical equipment. The specific preparation method is as follows: amlodipine mesylate, fast flow lactose (Flowlac  ), croscarmellose sodium, aspartame and peppermint essence were weighed respectively according to the amount, passed through an 80 mesh sieve and mixed evenly; then mixed with magnesium stearate, sieved and mixed evenly, and then the intermediate was carried out For content determination, directly compress the tablet according to the specified amount to obtain an orally disintegrating tablet.

Embodiment 3

[0053] The formulation of the present invention consists of the following components by weight percentage:

[0054] Amlodipine mesylate 5.0g

[0055] Microcrystalline Cellulose 80.0g

[0056] Mannitol 88.0g

[0057] Aspartame 1.8g

[0058] Mint essence 0.5g

[0059] Orange flavor 1.0g

[0060] Micronized silica gel 2.0g

[0061] Magnesium Stearate 1.0g

[0062] A total of 1000 pieces were made

[0063] The dosage form is prepared by direct compression technology using conventional tablet pharmaceutical equipment. The specific preparation method is as follows: Weigh amlodipine mesylate, microcrystalline cellulose, mannitol, aspartame, peppermint flavor, and orange flavor respectively according to the amount, pass through an 80-mesh sieve and mix evenly; Magnesium fatty acid and micropowder silica gel are mixed, sieved and mixed evenly, and then the content of this intermediate is determined, and the amount according to the specification is directly compressed into tablets...

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PUM

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Abstract

An oral disintegrating tablet of amlodipine methanesulfonate is prepared from amlodipine methanesulfonate, filler, disintegrant, effervescent agent, flavouring, lubricant and flowing aid through conventional process.

Description

technical field [0001] The invention belongs to pharmaceutical preparations, and relates to an orally disintegrating tablet formulation suitable for treating hypertension and angina pectoris, in particular to amlodipine mesylate orally disintegrating tablets and a preparation method thereof. Background technique [0002] Hypertension and angina pectoris are common and frequently-occurring diseases, which seriously endanger human life and health, and patients need continuous medication for life, so the research and development of such drugs has always been the focus of the global pharmaceutical industry. Amlodipine Mesylate (Amlodipine Mesylate, chemical name is (±) 2-[(2-aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6 -Methyl-3,5-pyridinedicarboxylic acid, 3-ethyl ester-5-methyl ester methanesulfonate monohydrate) is a calcium channel blocker with significant antihypertensive effect, and is the first-line treatment of hypertension and angina pectoris drug. It only ne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422
Inventor 张文伟郑文谢纲
Owner HANGZHOU MINSHENG PHARM CO LTD
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