Self-emulsifying vaccine adjuvant and preparation thereof

Abstract

A self-emulsifying adjuvant for vaccine is proportionally prepared from oil phase, hydrophilic surfactant, lipophilic surfactant and coemulsifier.

Description

technical field [0001] The invention relates to the field of vaccine adjuvant, in particular to a novel self-emulsifying vaccine adjuvant and a preparation method thereof. Background technique [0002] Although highly purified new vaccines have good antigen specificity and low toxicity, they have low immunogenicity and need to be used with high-efficiency adjuvants. An adjuvant is a substance that can non-specifically change or enhance the body's specific immune response to an antigen when it is injected into the animal before or at the same time as the antigen, also known as an immunopotentiator. [0003] As the development of vaccines has become increasingly complex, higher requirements have also been placed on adjuvants; for example, biochemical experts have discovered that: firstly, the effective antigens in the vaccines are purified (effective antigens usually refer to those in bacteria or viruses that can stimulate the immune response The component of the vaccine is a...

AI Technical Summary

Problems solved by technology

[0007] The invention discloses a new self-emulsifying vaccine adjuvant and its preparation method, which solves the difficult problem of preparation of W / O / W emulsion vaccine through self-emulsification technology, and the prepared W / O / W emulsion vaccine is stable Better than W / O / W emulsion vaccines prepared by existing adjuvants