Venous injection of secnidazole
A technology of secnidazole and injection, applied in the field of intravenous injection of secnidazole, can solve the problem of no injection production and marketing, etc.
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Embodiment 1
[0015] Take 2.5g of secnidazole, add about 700ml of water for injection (or isotonic solution), stir to dissolve, add water for injection (or isotonic solution) to 900ml, adjust the pH to 5.5~6.5, stir evenly, filter, and remove from the container Add water for injection (or isotonic solution) to 1000ml, fine filter, check the content of intermediate products, potting (50ml / bottle, 100ml / bottle, 250ml / bottle, 500ml / bottle), sterilize at 115°C for 30 minutes, clarity Check, pack, and serve. The test results are shown in Table 1.
[0016] name
[0017] Grain
Embodiment 2
[0019] Take about 700ml of water for injection, add 250g of secnidazole, 50g of 2-hydroxypropyl-β-cyclodextrin, 100g of mannitol, stir to dissolve, add water for injection to 900ml, adjust the pH to 5.5-6.5, stir well, filter, and Add water for injection to the container to 1000ml, fine filter, check the content of the intermediate product, pack into 2ml / bottle, and freeze-dry.
[0020] name
Embodiment 3
[0022] Take about 700ml of water for injection, add 125g of secnidazole, 100g of β-cyclodextrin, and 150g of hydroxypropyl cellulose sodium, stir to dissolve, add water for injection to 900ml, adjust the pH to 5.5-6.5, stir well, filter, and remove from the container Add water for injection to 1000ml, fine filter, check the content of the intermediate product, pack into 2ml / bottle, and freeze-dry to obtain.
[0023] name
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